48 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BIK	BCL2 interacting killer. (160 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	BCL2L10	Uncharacterized protein. (204 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	DIABLO	Uncharacterized protein. (166 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	BIRC8	Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
	G3QYB0_GORGO	TNF receptor superfamily member 10d. (386 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (298 aa)
	BAX	BCL2 associated X, apoptosis regulator. (217 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (440 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	DFFA	DNA fragmentation factor subunit alpha. (331 aa)
	DFFB	DNA fragmentation factor subunit beta. (338 aa)
	GLMP	Glycosylated lysosomal membrane protein. (406 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	G3RQE7_GORGO	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	FAS	Fas cell surface death receptor. (340 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (151 aa)
	ENSGGOP00000031130	Uncharacterized protein. (189 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	BCL2A1	BCL2 related protein A1. (196 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	BMF	Bcl2 modifying factor. (184 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (388 aa)
	BOK	BCL2 family apoptosis regulator BOK. (212 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (468 aa)
	G3RF33_GORGO	Tumor necrosis factor ligand superfamily member. (281 aa)
	RTL10	Retrotransposon Gag like 10. (361 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4883 aa)
	ENSGGOP00000049412	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
	BBC3	Uncharacterized protein. (101 aa)
	TNFRSF10C	TNF receptor superfamily member 10c. (284 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSGGOP00000035421	ENSGGOP00000018898	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.633
APAF1	BAX	ENSGGOP00000035421	ENSGGOP00000010113	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.611
APAF1	BBC3	ENSGGOP00000035421	ENSGGOP00000050504	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.467
APAF1	BCL2	ENSGGOP00000035421	ENSGGOP00000000778	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.913
APAF1	BCL2A1	ENSGGOP00000035421	ENSGGOP00000035210	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 related protein A1.	0.618
APAF1	BCL2L1	ENSGGOP00000035421	ENSGGOP00000020778	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.895
APAF1	BCL2L10	ENSGGOP00000035421	ENSGGOP00000003464	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.580
APAF1	BCL2L11	ENSGGOP00000035421	ENSGGOP00000047932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.688
APAF1	BID	ENSGGOP00000035421	ENSGGOP00000010297	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.446
APAF1	BIK	ENSGGOP00000035421	ENSGGOP00000000028	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 interacting killer.	0.522
APAF1	BIRC6	ENSGGOP00000035421	ENSGGOP00000049108	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 6.	0.875
APAF1	BIRC7	ENSGGOP00000035421	ENSGGOP00000008152	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.729
APAF1	BIRC8	ENSGGOP00000035421	ENSGGOP00000007398	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX.	0.849
APAF1	BOK	ENSGGOP00000035421	ENSGGOP00000045611	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.602
APAF1	CASP10	ENSGGOP00000035421	ENSGGOP00000011996	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.796
APAF1	CASP2	ENSGGOP00000035421	ENSGGOP00000003520	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.866
APAF1	CASP6	ENSGGOP00000035421	ENSGGOP00000028537	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6; Belongs to the peptidase C14A family.	0.810
APAF1	CASP7	ENSGGOP00000035421	ENSGGOP00000045233	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.895
APAF1	CASP9	ENSGGOP00000035421	ENSGGOP00000001932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSGGOP00000035421	ENSGGOP00000010692	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.799