STRINGSTRING
CASP9 CASP9 CASP2 CASP2 RIPK3 RIPK3 DIABLO DIABLO BIRC8 BIRC8 G3QYB0_GORGO G3QYB0_GORGO BIRC7 BIRC7 CFLAR CFLAR TNFRSF10B TNFRSF10B CASP10 CASP10 RIPK1 RIPK1 DFFA DFFA DFFB DFFB G3RQE7_GORGO G3RQE7_GORGO FADD FADD CRADD CRADD FASLG FASLG FAS FAS CYCS CYCS CASP6 CASP6 PIDD1 PIDD1 ENSGGOP00000033404 ENSGGOP00000033404 APAF1 APAF1 CASP7 CASP7 TNFRSF10A TNFRSF10A G3RF33_GORGO G3RF33_GORGO BIRC6 BIRC6 ENSGGOP00000049412 ENSGGOP00000049412 TNFRSF10C TNFRSF10C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
DIABLOUncharacterized protein. (166 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
G3QYB0_GORGOTNF receptor superfamily member 10d. (386 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
DFFBDNA fragmentation factor subunit beta. (338 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
FASFas cell surface death receptor. (340 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
G3RF33_GORGOTumor necrosis factor ligand superfamily member. (281 aa)
BIRC6Baculoviral IAP repeat containing 6. (4883 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
TNFRSF10CTNF receptor superfamily member 10c. (284 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (18%) [HD]