29 items (Gorilla gorilla) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	DIABLO	Uncharacterized protein. (166 aa)
	BIRC8	Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
	G3QYB0_GORGO	TNF receptor superfamily member 10d. (386 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (298 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (440 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	DFFA	DNA fragmentation factor subunit alpha. (331 aa)
	DFFB	DNA fragmentation factor subunit beta. (338 aa)
	G3RQE7_GORGO	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	FAS	Fas cell surface death receptor. (340 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (388 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (468 aa)
	G3RF33_GORGO	Tumor necrosis factor ligand superfamily member. (281 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4883 aa)
	ENSGGOP00000049412	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
	TNFRSF10C	TNF receptor superfamily member 10c. (284 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC6	ENSGGOP00000035421	ENSGGOP00000049108	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 6.	0.875
APAF1	BIRC7	ENSGGOP00000035421	ENSGGOP00000008152	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.729
APAF1	BIRC8	ENSGGOP00000035421	ENSGGOP00000007398	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX.	0.849
APAF1	CASP10	ENSGGOP00000035421	ENSGGOP00000011996	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.796
APAF1	CASP2	ENSGGOP00000035421	ENSGGOP00000003520	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.866
APAF1	CASP6	ENSGGOP00000035421	ENSGGOP00000028537	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6; Belongs to the peptidase C14A family.	0.810
APAF1	CASP7	ENSGGOP00000035421	ENSGGOP00000045233	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.895
APAF1	CASP9	ENSGGOP00000035421	ENSGGOP00000001932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSGGOP00000035421	ENSGGOP00000010692	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.799
APAF1	CRADD	ENSGGOP00000035421	ENSGGOP00000021798	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.568
APAF1	CYCS	ENSGGOP00000035421	ENSGGOP00000028382	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.999
APAF1	DFFA	ENSGGOP00000035421	ENSGGOP00000012405	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DNA fragmentation factor subunit alpha.	0.442
APAF1	DFFB	ENSGGOP00000035421	ENSGGOP00000013122	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DNA fragmentation factor subunit beta.	0.459
APAF1	DIABLO	ENSGGOP00000035421	ENSGGOP00000005240	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.914
APAF1	ENSGGOP00000033404	ENSGGOP00000035421	ENSGGOP00000033404	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.880
APAF1	ENSGGOP00000049412	ENSGGOP00000035421	ENSGGOP00000049412	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.986
APAF1	FADD	ENSGGOP00000035421	ENSGGOP00000020107	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.646
APAF1	FAS	ENSGGOP00000035421	ENSGGOP00000027099	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas cell surface death receptor.	0.461
APAF1	FASLG	ENSGGOP00000035421	ENSGGOP00000024877	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand; Belongs to the tumor necrosis factor family.	0.588
APAF1	G3RF33_GORGO	ENSGGOP00000035421	ENSGGOP00000047069	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor ligand superfamily member.	0.438