node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BIRC6 | ENSGGOP00000035421 | ENSGGOP00000049108 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 6. | 0.875 |
APAF1 | BIRC7 | ENSGGOP00000035421 | ENSGGOP00000008152 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 7. | 0.729 |
APAF1 | BIRC8 | ENSGGOP00000035421 | ENSGGOP00000007398 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | 0.849 |
APAF1 | CASP10 | ENSGGOP00000035421 | ENSGGOP00000011996 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 10; Belongs to the peptidase C14A family. | 0.796 |
APAF1 | CASP2 | ENSGGOP00000035421 | ENSGGOP00000003520 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 2; Belongs to the peptidase C14A family. | 0.866 |
APAF1 | CASP6 | ENSGGOP00000035421 | ENSGGOP00000028537 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 6; Belongs to the peptidase C14A family. | 0.810 |
APAF1 | CASP7 | ENSGGOP00000035421 | ENSGGOP00000045233 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 7; Belongs to the peptidase C14A family. | 0.895 |
APAF1 | CASP9 | ENSGGOP00000035421 | ENSGGOP00000001932 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CFLAR | ENSGGOP00000035421 | ENSGGOP00000010692 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | 0.799 |
APAF1 | CRADD | ENSGGOP00000035421 | ENSGGOP00000021798 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP2 and RIPK1 domain containing adaptor with death domain. | 0.568 |
APAF1 | CYCS | ENSGGOP00000035421 | ENSGGOP00000028382 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | DFFA | ENSGGOP00000035421 | ENSGGOP00000012405 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | DNA fragmentation factor subunit alpha. | 0.442 |
APAF1 | DFFB | ENSGGOP00000035421 | ENSGGOP00000013122 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | DNA fragmentation factor subunit beta. | 0.459 |
APAF1 | DIABLO | ENSGGOP00000035421 | ENSGGOP00000005240 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.914 |
APAF1 | ENSGGOP00000033404 | ENSGGOP00000035421 | ENSGGOP00000033404 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 8; Belongs to the peptidase C14A family. | 0.880 |
APAF1 | ENSGGOP00000049412 | ENSGGOP00000035421 | ENSGGOP00000049412 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.986 |
APAF1 | FADD | ENSGGOP00000035421 | ENSGGOP00000020107 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.646 |
APAF1 | FAS | ENSGGOP00000035421 | ENSGGOP00000027099 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Fas cell surface death receptor. | 0.461 |
APAF1 | FASLG | ENSGGOP00000035421 | ENSGGOP00000024877 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Fas ligand; Belongs to the tumor necrosis factor family. | 0.588 |
APAF1 | G3RF33_GORGO | ENSGGOP00000035421 | ENSGGOP00000047069 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Tumor necrosis factor ligand superfamily member. | 0.438 |