node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS3 | G3QT76_GORGO | ENSGGOP00000003522 | ENSGGOP00000005887 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.405 |
ADAMTS3 | IL1B | ENSGGOP00000003522 | ENSGGOP00000006245 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.483 |
ADGRG1 | COL3A1 | ENSGGOP00000008255 | ENSGGOP00000016147 | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] | Collagen type III alpha 1 chain. | 0.540 |
ADGRG1 | ITGAV | ENSGGOP00000008255 | ENSGGOP00000043070 | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.582 |
CMA1 | IL1B | ENSGGOP00000014824 | ENSGGOP00000006245 | Chymase 1; Belongs to the peptidase S1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.410 |
COL3A1 | ADGRG1 | ENSGGOP00000016147 | ENSGGOP00000008255 | Collagen type III alpha 1 chain. | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] | 0.540 |
COL3A1 | ITGAV | ENSGGOP00000016147 | ENSGGOP00000043070 | Collagen type III alpha 1 chain. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.513 |
ENSGGOP00000045267 | ENSGGOP00000046758 | ENSGGOP00000045267 | ENSGGOP00000046758 | Uncharacterized protein; Belongs to the peptidase C14A family. | Caspase 1; Belongs to the peptidase C14A family. | 0.546 |
ENSGGOP00000045267 | G3QT76_GORGO | ENSGGOP00000045267 | ENSGGOP00000005887 | Uncharacterized protein; Belongs to the peptidase C14A family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.462 |
ENSGGOP00000045267 | IL1B | ENSGGOP00000045267 | ENSGGOP00000006245 | Uncharacterized protein; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.745 |
ENSGGOP00000046758 | ENSGGOP00000045267 | ENSGGOP00000046758 | ENSGGOP00000045267 | Caspase 1; Belongs to the peptidase C14A family. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.546 |
ENSGGOP00000046758 | G3QT76_GORGO | ENSGGOP00000046758 | ENSGGOP00000005887 | Caspase 1; Belongs to the peptidase C14A family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.745 |
ENSGGOP00000046758 | IL1B | ENSGGOP00000046758 | ENSGGOP00000006245 | Caspase 1; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.996 |
ENSGGOP00000046758 | IL6 | ENSGGOP00000046758 | ENSGGOP00000018546 | Caspase 1; Belongs to the peptidase C14A family. | Interleukin 6. | 0.730 |
ENSGGOP00000046758 | TLR3 | ENSGGOP00000046758 | ENSGGOP00000027247 | Caspase 1; Belongs to the peptidase C14A family. | Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. | 0.559 |
G3QF38_GORGO | G3QT76_GORGO | ENSGGOP00000000901 | ENSGGOP00000005887 | Forkhead box P3. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.695 |
G3QF38_GORGO | HIF1A | ENSGGOP00000000901 | ENSGGOP00000028093 | Forkhead box P3. | Hypoxia inducible factor 1 subunit alpha. | 0.815 |
G3QF38_GORGO | IL1B | ENSGGOP00000000901 | ENSGGOP00000006245 | Forkhead box P3. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.656 |
G3QF38_GORGO | IL6 | ENSGGOP00000000901 | ENSGGOP00000018546 | Forkhead box P3. | Interleukin 6. | 0.761 |
G3QF38_GORGO | IL6R | ENSGGOP00000000901 | ENSGGOP00000000824 | Forkhead box P3. | Interleukin 6 receptor. | 0.483 |