(103 nodes) Neural tube closure network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	RARA	Uncharacterized protein. (624 aa)
	G3QK90_GORGO	Uncharacterized protein. (206 aa)
	G3QJW7_GORGO	Coiled-coil and C2 domain containing 2A. (1620 aa)
	GRHL3	Grainyhead like transcription factor 3. (626 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	KIF20B	Kinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1821 aa)
	STIL	STIL centriolar assembly protein. (1242 aa)
	LMO4	LIM domain only 4. (165 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2892 aa)
	IFT172	Intraflagellar transport 172. (1749 aa)
	RARG	Retinoic acid receptor gamma. (451 aa)
	SCRIB	Scribble planar cell polarity protein. (1658 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	ENSGGOP00000051208	DUF3384 domain-containing protein. (525 aa)
	ENSGGOP00000051050	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (187 aa)
	ENSGGOP00000050768	Paired box 2. (392 aa)
	DVL3	Dishevelled segment polarity protein 3. (77 aa)
	ENSGGOP00000049802	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (192 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	RALA	Uncharacterized protein. (112 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	PTCH1	Patched 1. (1447 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1499 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	ENSGGOP00000041060	TEA domain transcription factor 2. (451 aa)
	ENSGGOP00000040417	Profilin; Belongs to the profilin family. (122 aa)
	KDM2B	JmjC domain-containing protein. (79 aa)
	ENSGGOP00000039096	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (177 aa)
	ENSGGOP00000038825	THF_DHG_CYH_C domain-containing protein. (885 aa)
	ENSGGOP00000037801	Uncharacterized protein. (203 aa)
	ENSGGOP00000036799	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	RGMA	Repulsive guidance molecule BMP co-receptor a. (458 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	ENSGGOP00000032040	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	PHACTR4	Phosphatase and actin regulator. (712 aa)
	ENSGGOP00000031389	Clusterin associated protein 1. (418 aa)
	ENSGGOP00000031377	Bromodomain containing 2. (836 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (697 aa)
	ENSGGOP00000029961	CECR2 histone acetyl-lysine reader. (1420 aa)
	MED12	Mediator complex subunit 12. (2177 aa)
	ENSGGOP00000029233	Dishevelled segment polarity protein 1. (695 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	LIAS	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ENSGGOP00000024523	annotation not available (408 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
	G3S4D8_GORGO	Lysine demethylase 6A. (1453 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	RPS7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	G3S1U3_GORGO	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	SALL4	Spalt like transcription factor 4. (1053 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1248 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2598 aa)
	TSC2	TSC complex subunit 2. (1806 aa)
	G3RSK3_GORGO	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (206 aa)
	G3RS83_GORGO	Cyclin dependent kinase 20. (283 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (993 aa)
	TULP3	TUB like protein 3; Belongs to the TUB family. (501 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	G3RN58_GORGO	Intraflagellar transport 122. (1241 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	LRP2	LDL receptor related protein 2. (4653 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (833 aa)
	G3RDS9_GORGO	Lysine demethylase 2B. (1252 aa)
	G3RDR4_GORGO	DEAF1 transcription factor. (559 aa)
	VANGL2	Vang-like protein. (521 aa)
	ADM	Adrenomedullin. (185 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	G3R4L4_GORGO	SKI proto-oncogene. (700 aa)
	FUZ	Fuzzy planar cell polarity protein. (418 aa)
	VASP	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
	G3R270_GORGO	Cordon-bleu WH2 repeat protein. (1294 aa)
	LHX2	LIM homeobox 2. (406 aa)
	TBXT	T-box transcription factor T. (435 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	G3QWV4_GORGO	Dishevelled segment polarity protein 3. (704 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (529 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
	GLMN	Glomulin, FKBP associated protein. (594 aa)
	PLXNB2	Plexin B2. (1838 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	FOLR1	Folate receptor alpha. (257 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	SHROOM3	Shroom family member 3. (1996 aa)
	G3QPK5_GORGO	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
	BBS4	Bardet-Biedl syndrome 4. (519 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	APAF1	ENSGGOP00000010326	ENSGGOP00000035421	Tyrosine-protein kinase.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.468
ABL1	ARHGAP35	ENSGGOP00000010326	ENSGGOP00000044836	Tyrosine-protein kinase.	Rho GTPase activating protein 35.	0.434
ABL1	CASP3	ENSGGOP00000010326	ENSGGOP00000021659	Tyrosine-protein kinase.	Caspase 3; Belongs to the peptidase C14A family.	0.508
ABL1	RARA	ENSGGOP00000010326	ENSGGOP00000003063	Tyrosine-protein kinase.	Uncharacterized protein.	0.552
ABL1	VASP	ENSGGOP00000010326	ENSGGOP00000009657	Tyrosine-protein kinase.	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.	0.640
APAF1	ABL1	ENSGGOP00000035421	ENSGGOP00000010326	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tyrosine-protein kinase.	0.468
APAF1	CASP3	ENSGGOP00000035421	ENSGGOP00000021659	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.995
ARHGAP35	ABL1	ENSGGOP00000044836	ENSGGOP00000010326	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.434
ARHGAP35	PLXNB2	ENSGGOP00000044836	ENSGGOP00000006493	Rho GTPase activating protein 35.	Plexin B2.	0.469
BBS4	ENSGGOP00000031389	ENSGGOP00000003833	ENSGGOP00000031389	Bardet-Biedl syndrome 4.	Clusterin associated protein 1.	0.569
BBS4	G3RN58_GORGO	ENSGGOP00000003833	ENSGGOP00000017224	Bardet-Biedl syndrome 4.	Intraflagellar transport 122.	0.480
BBS4	IFT172	ENSGGOP00000003833	ENSGGOP00000001048	Bardet-Biedl syndrome 4.	Intraflagellar transport 172.	0.662
BBS4	IFT57	ENSGGOP00000003833	ENSGGOP00000006665	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.629
BBS4	MKS1	ENSGGOP00000003833	ENSGGOP00000003088	Bardet-Biedl syndrome 4.	MKS transition zone complex subunit 1.	0.598
BBS4	STIL	ENSGGOP00000003833	ENSGGOP00000000503	Bardet-Biedl syndrome 4.	STIL centriolar assembly protein.	0.470
BCL10	ENSGGOP00000035952	ENSGGOP00000051225	ENSGGOP00000035952	CARD domain-containing protein.	TNF receptor-associated factor.	0.645
BCL10	TRAF6	ENSGGOP00000051225	ENSGGOP00000005734	CARD domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.933
BMP4	PTCH1	ENSGGOP00000014564	ENSGGOP00000046413	Bone morphogenetic protein 4.	Patched 1.	0.430
BMP4	RGMA	ENSGGOP00000014564	ENSGGOP00000036628	Bone morphogenetic protein 4.	Repulsive guidance molecule BMP co-receptor a.	0.631
BMP4	TBXT	ENSGGOP00000014564	ENSGGOP00000007525	Bone morphogenetic protein 4.	T-box transcription factor T.	0.794