STRINGSTRING
ENSGGOP00000052295 ENSGGOP00000052295 ENSGGOP00000051997 ENSGGOP00000051997 BCL10 BCL10 ENSGGOP00000048129 ENSGGOP00000048129 HMOX1 HMOX1 ENSGGOP00000045913 ENSGGOP00000045913 ENSGGOP00000043190 ENSGGOP00000043190 GPRC5B GPRC5B TNFRSF14 TNFRSF14 ENSGGOP00000038993 ENSGGOP00000038993 MAPKAPK2 MAPKAPK2 FZD5 FZD5 ENSGGOP00000035952 ENSGGOP00000035952 BCL6 BCL6 APOA1 APOA1 ENSGGOP00000031193 ENSGGOP00000031193 DHX36 DHX36 ARID5A ARID5A SLC7A5 SLC7A5 PLCG2 PLCG2 TLR3 TLR3 MIF MIF TRIL TRIL SCIMP SCIMP B2M B2M TGFB1 TGFB1 G3SAQ4_GORGO G3SAQ4_GORGO BTK BTK DDX58 DDX58 G3S3V1_GORGO G3S3V1_GORGO ANGPT1 ANGPT1 NOD1 NOD1 INAVA INAVA G3S124_GORGO G3S124_GORGO CD55 CD55 MAP3K7 MAP3K7 TLR7 TLR7 MALT1 MALT1 SLAMF1 SLAMF1 G3RUA1_GORGO G3RUA1_GORGO NR4A3 NR4A3 G3RTS2_GORGO G3RTS2_GORGO G3RT65_GORGO G3RT65_GORGO DDX50 DDX50 IL6 IL6 RTN4 RTN4 G3RRQ8_GORGO G3RRQ8_GORGO ARG1 ARG1 TNFSF4 TNFSF4 G3RRC5_GORGO G3RRC5_GORGO G3RR32_GORGO G3RR32_GORGO CCR2 CCR2 IFNB1 IFNB1 PYCARD PYCARD LAPTM5 LAPTM5 G3RKL3_GORGO G3RKL3_GORGO ATG5 ATG5 HK1 HK1 IL18 IL18 KIT KIT BST2 BST2 SASH3 SASH3 IL10 IL10 UBE2J1 UBE2J1 PRKCZ PRKCZ IL18R1 IL18R1 G3RAL4_GORGO G3RAL4_GORGO DDX1 DDX1 ACP5 ACP5 LILRB4 LILRB4 G3R7S6_GORGO G3R7S6_GORGO RIPK2 RIPK2 NOD2 NOD2 CD96 CD96 RSAD2 RSAD2 SMAD7 SMAD7 SYK SYK G3R475_GORGO G3R475_GORGO SIRT1 SIRT1 G3R3U7_GORGO G3R3U7_GORGO LACC1 LACC1 TRPM4 TRPM4 TNFRSF1B TNFRSF1B CD81 CD81 WNT5A WNT5A TRAF2 TRAF2 G3QW36_GORGO G3QW36_GORGO F2RL1 F2RL1 CUEDC2 CUEDC2 CLNK CLNK G3QUW7_GORGO G3QUW7_GORGO SEMA7A SEMA7A IL1B IL1B HFE HFE GATA3 GATA3 CD36 CD36 CD226 CD226 G3QT76_GORGO G3QT76_GORGO FFAR2 FFAR2 TRAF6 TRAF6 G3QSH5_GORGO G3QSH5_GORGO PANX-2 PANX-2 G3QRP1_GORGO G3QRP1_GORGO DDX21 DDX21 NLRP3 NLRP3 G3QPK5_GORGO G3QPK5_GORGO MYD88 MYD88 IL1R1 IL1R1 NLRX1 NLRX1 EPX EPX SPON2 SPON2 TBX21 TBX21 TGFB3 TGFB3 G3QF38_GORGO G3QF38_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGGOP00000052295A20-type domain-containing protein. (104 aa)
ENSGGOP00000051997C-type lectin domain containing 7A. (247 aa)
BCL10CARD domain-containing protein. (316 aa)
ENSGGOP00000048129Caspase recruitment domain family member 9. (536 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
ENSGGOP00000045913DENN domain containing 1B. (775 aa)
ENSGGOP00000043190Uncharacterized protein. (234 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
TNFRSF14Uncharacterized protein. (193 aa)
ENSGGOP00000038993Helicase C-terminal domain-containing protein. (363 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ENSGGOP00000035952TNF receptor-associated factor. (485 aa)
BCL6BCL6 transcription repressor. (706 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
ENSGGOP00000031193Uncharacterized protein. (93 aa)
DHX36DEAH-box helicase 36. (1008 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
TRILTLR4 interactor with leucine rich repeats. (811 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (144 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
G3SAQ4_GORGOBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (66 aa)
BTKTyrosine-protein kinase. (693 aa)
DDX58DExD/H-box helicase 58. (925 aa)
G3S3V1_GORGOHelicase C-terminal domain-containing protein. (318 aa)
ANGPT1Angiopoietin 1. (498 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
INAVAInnate immunity activator. (663 aa)
G3S124_GORGOKiller cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (405 aa)
CD55Uncharacterized protein. (551 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MALT1MALT1 paracaspase. (824 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
G3RUA1_GORGOIGc1 domain-containing protein; Belongs to the MHC class I family. (398 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (550 aa)
G3RTS2_GORGOA20-type domain-containing protein. (118 aa)
G3RT65_GORGOSphingosine kinase 2. (663 aa)
DDX50DExD-box helicase 50. (737 aa)
IL6Interleukin 6. (234 aa)
RTN4Reticulon. (1192 aa)
G3RRQ8_GORGOAXL receptor tyrosine kinase. (843 aa)
ARG1Arginase. (322 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
G3RRC5_GORGOUncharacterized protein. (491 aa)
G3RR32_GORGOUncharacterized protein. (382 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IFNB1Interferon beta 1. (187 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
G3RKL3_GORGOMHC_I-like_Ag-recog domain-containing protein. (393 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
HK1Hexokinase 1. (921 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
BST2Bone marrow stromal antigen 2. (185 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
IL10Interleukin 10. (178 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
DDX1DEAD-box helicase 1. (740 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
LILRB4Ig-like domain-containing protein. (342 aa)
G3R7S6_GORGOCD74 molecule. (296 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CD96CD96 molecule. (576 aa)
RSAD2Elp3 domain-containing protein. (361 aa)
SMAD7MH2 domain-containing protein. (211 aa)
SYKTyrosine-protein kinase. (635 aa)
G3R475_GORGORAB guanine nucleotide exchange factor 1. (469 aa)
SIRT1Sirtuin 1. (751 aa)
G3R3U7_GORGOMitochondrial antiviral signaling protein. (481 aa)
LACC1Uncharacterized protein. (430 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1292 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
CD81Tetraspanin. (260 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TRAF2TNF receptor-associated factor. (451 aa)
G3QW36_GORGOUncharacterized protein. (652 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
CUEDC2CUE domain containing 2. (287 aa)
CLNKCytokine dependent hematopoietic cell linker. (428 aa)
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
GATA3GATA binding protein 3. (444 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CD226CD226 molecule. (336 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
G3QSH5_GORGOTyrosine-protein kinase. (1124 aa)
PANX-2Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
G3QRP1_GORGOUncharacterized protein. (107 aa)
DDX21DExD-box helicase 21. (783 aa)
NLRP3NLR family pyrin domain containing 3. (1028 aa)
G3QPK5_GORGOTransforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
NLRX1NLR family member X1. (975 aa)
EPXEosinophil peroxidase. (715 aa)
SPON2Spondin 2. (331 aa)
TBX21T-box transcription factor 21. (535 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
G3QF38_GORGOForkhead box P3. (441 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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