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| | G3QK95_GORGO | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (125 aa) |
| | LRPPRC | PPR_long domain-containing protein. (407 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | ENSGGOP00000049283 | LisH domain-containing protein. (345 aa) |
| | FBH1 | F-box DNA helicase 1. (1096 aa) |
| | APTX | Aprataxin. (330 aa) |
| | ENSGGOP00000048733 | RAD23 homolog A, nucleotide excision repair protein. (376 aa) |
| | RAD51B | Uncharacterized protein. (118 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | ERCC5 | BIVM-ERCC5 readthrough. (1633 aa) |
| | WDR48 | WD repeat domain 48. (689 aa) |
| | ENSGGOP00000046289 | RAD51_interact domain-containing protein. (288 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1197 aa) |
| | ENSGGOP00000045852 | Uncharacterized protein. (404 aa) |
| | ENSGGOP00000044527 | Uncharacterized protein. (673 aa) |
| | ENSGGOP00000043187 | annotation not available (111 aa) |
| | NOL12 | Uncharacterized protein. (213 aa) |
| | ENSGGOP00000042442 | Uncharacterized protein. (137 aa) |
| | ENSGGOP00000042130 | Uncharacterized protein. (112 aa) |
| | ENSGGOP00000041237 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (377 aa) |
| | ENSGGOP00000039935 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa) |
| | ENSGGOP00000039627 | Uncharacterized protein. (556 aa) |
| | ENSGGOP00000038747 | Uncharacterized protein. (1063 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (825 aa) |
| | ENSGGOP00000038080 | Uncharacterized protein. (54 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (248 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | ENSGGOP00000037523 | Uncharacterized protein. (181 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | WBP11 | WW domain binding protein 11. (668 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | ENSGGOP00000036676 | LisH domain-containing protein. (404 aa) |
| | RBBP8 | CtIP_N domain-containing protein. (896 aa) |
| | ENSGGOP00000036545 | RPA_C domain-containing protein. (228 aa) |
| | ENSGGOP00000036254 | Uncharacterized protein. (178 aa) |
| | ENSGGOP00000035318 | LisH domain-containing protein. (380 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (608 aa) |
| | ENSGGOP00000032315 | Uncharacterized protein. (111 aa) |
| | SUB1 | SUB1 regulator of transcription. (127 aa) |
| | DDX11 | DEAD/H-box helicase 11. (951 aa) |
| | SSBP3 | Single stranded DNA binding protein 3. (369 aa) |
| | TSNAX | Translin associated factor X. (290 aa) |
| | ENSGGOP00000030646 | Uncharacterized protein. (111 aa) |
| | DHX36 | DEAH-box helicase 36. (1008 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3416 aa) |
| | G3SG85_GORGO | Uncharacterized protein. (351 aa) |
| | DHX9 | DExH-box helicase 9. (1270 aa) |
| | PURB | Purine rich element binding protein B. (312 aa) |
| | TERF2IP | TERF2 interacting protein. (399 aa) |
| | SSBP2 | Single stranded DNA binding protein 2. (358 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | G3SB61_GORGO | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa) |
| | MYEF2 | Myelin expression factor 2. (600 aa) |
| | G3S8E4_GORGO | CSP domain-containing protein. (314 aa) |
| | G3S509_GORGO | Poly(rC) binding protein 1. (356 aa) |
| | G3S2R7_GORGO | CSP domain-containing protein. (280 aa) |
| | G3S0K0_GORGO | Cell division cycle 45. (598 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (611 aa) |
| | G3RTH8_GORGO | POU domain protein. (259 aa) |
| | G3RT71_GORGO | CSD_1 domain-containing protein. (318 aa) |
| | POLA1 | DNA polymerase. (1458 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (855 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (293 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa) |
| | G3RL86_GORGO | Single stranded DNA binding protein 4. (385 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (606 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | TWNK | Twinkle mtDNA helicase. (582 aa) |
| | LONP1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (959 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | REXO4 | REX4 homolog, 3'-5' exonuclease. (422 aa) |
| | G3REI5_GORGO | RecQ like helicase 4. (1210 aa) |
| | G3RED9_GORGO | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (585 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (876 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | G3RCP0_GORGO | HSF_DOMAIN domain-containing protein. (527 aa) |
| | RTF1 | RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa) |
| | G3RAR0_GORGO | Uncharacterized protein. (714 aa) |
| | PCBP2 | Poly(rC) binding protein 2. (366 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | IGHMBP2 | Immunoglobulin mu DNA binding protein 2. (997 aa) |
| | POLR2G | RNA polymerase II subunit G. (172 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa) |
| | FUBP3 | Far upstream element binding protein 3. (572 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (657 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (940 aa) |
| | NUP35 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (326 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (495 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa) |
| | BLM | BLM RecQ like helicase. (1415 aa) |
| | POLR3C | RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (418 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (861 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | G3QQG6_GORGO | SET domain and mariner transposase fusion gene. (684 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1159 aa) |
| | YBX1 | Y-box binding protein 1. (324 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | G3QN95_GORGO | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1095 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1064 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1079 aa) |
| | HNRNPDL | Heterogeneous nuclear ribonucleoprotein D like. (420 aa) |
| | G3QM87_GORGO | Poly(rC) binding protein 3. (371 aa) |
| | HROB | Chromosome 17 open reading frame 53. (634 aa) |
| | SPRTN | SprT-like N-terminal domain. (488 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (409 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (614 aa) |
| | TSN | Translin. (228 aa) |
| | PURA | Purine rich element binding protein A. (305 aa) |
| | RBMS1 | Uncharacterized protein. (389 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1408 aa) |
