node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | G3QRG5_GORGO | ENSGGOP00000032053 | ENSGGOP00000005217 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Neurotrophin 4; Belongs to the NGF-beta family. | 0.976 |
BDNF | NGF | ENSGGOP00000032053 | ENSGGOP00000033777 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.748 |
BDNF | NTF3 | ENSGGOP00000032053 | ENSGGOP00000043594 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.715 |
BEX3 | NGF | ENSGGOP00000032135 | ENSGGOP00000033777 | Brain expressed X-linked 3. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.656 |
BEX3 | NTF3 | ENSGGOP00000032135 | ENSGGOP00000043594 | Brain expressed X-linked 3. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.431 |
BID | CFLAR | ENSGGOP00000010297 | ENSGGOP00000010692 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | 0.780 |
BID | ENSGGOP00000033404 | ENSGGOP00000010297 | ENSGGOP00000033404 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 8; Belongs to the peptidase C14A family. | 0.923 |
BID | FADD | ENSGGOP00000010297 | ENSGGOP00000020107 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.832 |
BID | FASLG | ENSGGOP00000010297 | ENSGGOP00000024877 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Fas ligand; Belongs to the tumor necrosis factor family. | 0.792 |
BID | PIDD1 | ENSGGOP00000010297 | ENSGGOP00000029519 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | P53-induced death domain protein 1. | 0.915 |
CASP8AP2 | ENSGGOP00000033404 | ENSGGOP00000016720 | ENSGGOP00000033404 | Caspase 8 associated protein 2. | Caspase 8; Belongs to the peptidase C14A family. | 0.755 |
CFLAR | BID | ENSGGOP00000010692 | ENSGGOP00000010297 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.780 |
CFLAR | ENSGGOP00000033404 | ENSGGOP00000010692 | ENSGGOP00000033404 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Caspase 8; Belongs to the peptidase C14A family. | 0.998 |
CFLAR | FADD | ENSGGOP00000010692 | ENSGGOP00000020107 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
CFLAR | FASLG | ENSGGOP00000010692 | ENSGGOP00000024877 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Fas ligand; Belongs to the tumor necrosis factor family. | 0.766 |
CFLAR | RIPK1 | ENSGGOP00000010692 | ENSGGOP00000012277 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.975 |
DAB2IP | RIPK1 | ENSGGOP00000031363 | ENSGGOP00000012277 | DAB2 interacting protein. | Receptor interacting serine/threonine kinase 1. | 0.572 |
EDA | EDARADD | ENSGGOP00000005788 | ENSGGOP00000046106 | Ectodysplasin A; Belongs to the tumor necrosis factor family. | EDAR associated death domain. | 0.480 |
EDARADD | EDA | ENSGGOP00000046106 | ENSGGOP00000005788 | EDAR associated death domain. | Ectodysplasin A; Belongs to the tumor necrosis factor family. | 0.480 |
ENSGGOP00000033404 | BID | ENSGGOP00000033404 | ENSGGOP00000010297 | Caspase 8; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.923 |