STRINGSTRING
G3QRG5_GORGO G3QRG5_GORGO EDA EDA TMBIM1 TMBIM1 MADD MADD BID BID CFLAR CFLAR NOL3 NOL3 RIPK1 RIPK1 CASP8AP2 CASP8AP2 FADD FADD FASLG FASLG PIDD1 PIDD1 DAB2IP DAB2IP BDNF BDNF BEX3 BEX3 ENSGGOP00000033404 ENSGGOP00000033404 NGF NGF FEM1B FEM1B NTF3 NTF3 EDARADD EDARADD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QRG5_GORGONeurotrophin 4; Belongs to the NGF-beta family. (210 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
MADDMAP kinase activating death domain. (1647 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
NOL3Nucleolar protein 3. (287 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CASP8AP2Caspase 8 associated protein 2. (1972 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
BEX3Brain expressed X-linked 3. (121 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
FEM1BFem-1 homolog B. (627 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
EDARADDEDAR associated death domain. (215 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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