91 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CARD8	Caspase recruitment domain family member 8. (522 aa)
	SLC1A1	Amino acid transporter. (524 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (114 aa)
	ROBO1	Roundabout guidance receptor 1. (1651 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1051 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1578 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	BCL2L10	Uncharacterized protein. (204 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	G3QMN8_GORGO	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (236 aa)
	NLRP3	NLR family pyrin domain containing 3. (1028 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1059 aa)
	DIABLO	Uncharacterized protein. (166 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	G3QXD0_GORGO	Apoptosis inducing factor mitochondria associated 1. (586 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	NLRP12	NLR family pyrin domain containing 12. (1065 aa)
	SLC11A2	Solute carrier family 11 member 2. (590 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	BAX	BCL2 associated X, apoptosis regulator. (217 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	TNFSF15	TNF superfamily member 15. (251 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	XDH	Xanthine dehydrogenase. (1333 aa)
	NLRP1	NLR family pyrin domain containing 1. (1471 aa)
	ANP32B	Acidic nuclear phosphoprotein 32 family member B. (250 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
	ST20	Uncharacterized protein. (79 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	G3R9D3_GORGO	Uncharacterized protein; Belongs to the GroES chaperonin family. (90 aa)
	SLC22A2	Solute carrier family 22 member 2. (547 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (262 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1972 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	KHDC1L	KH domain containing 1 like. (128 aa)
	G3RPM5_GORGO	Promyelocytic leukemia. (834 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (93 aa)
	G3RX86_GORGO	Uncharacterized protein; Belongs to the GroES chaperonin family. (98 aa)
	G3S075_GORGO	Uncharacterized protein. (229 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	G3S1J2_GORGO	Uncharacterized protein. (420 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	G3S8F5_GORGO	Uncharacterized protein. (237 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
	RPS27L	40S ribosomal protein S27. (96 aa)
	SENP1	SUMO specific peptidase 1. (644 aa)
	ENSGGOP00000027573	annotation not available (93 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	ENSGGOP00000030478	Tyrosine-protein kinase. (1151 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (167 aa)
	ENSGGOP00000031106	WD_REPEATS_REGION domain-containing protein. (321 aa)
	ENSGGOP00000031130	Uncharacterized protein. (189 aa)
	ENSGGOP00000031439	ULP_PROTEASE domain-containing protein. (562 aa)
	LCK	Tyrosine-protein kinase. (524 aa)
	BEX3	Brain expressed X-linked 3. (121 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	HIP1	Huntingtin interacting protein 1. (1015 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	NKX3-1	NK3 homeobox 1. (234 aa)
	ENSGGOP00000034749	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	KHDC1	MOEP19 domain-containing protein. (237 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	PDCD2	Programmed cell death 2. (344 aa)
	ENSGGOP00000045267	Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
	SMAD3	Mothers against decapentaplegic homolog. (356 aa)
	BOK	BCL2 family apoptosis regulator BOK. (212 aa)
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	ENSGGOP00000047931	Uncharacterized protein. (94 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	ENSGGOP00000048159	Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
	ENSGGOP00000048374	Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (345 aa)
	DAP	Death associated protein. (185 aa)
	BBC3	Uncharacterized protein. (101 aa)
	ENSGGOP00000050739	MOEP19 domain-containing protein. (151 aa)
	FAM162A	Family with sequence similarity 162 member A. (172 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSGGOP00000035421	ENSGGOP00000018898	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.633
APAF1	BAX	ENSGGOP00000035421	ENSGGOP00000010113	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.611
APAF1	BBC3	ENSGGOP00000035421	ENSGGOP00000050504	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.467
APAF1	BCL2L10	ENSGGOP00000035421	ENSGGOP00000003464	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.580
APAF1	BCL2L11	ENSGGOP00000035421	ENSGGOP00000047932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.688
APAF1	BID	ENSGGOP00000035421	ENSGGOP00000010297	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.446
APAF1	BOK	ENSGGOP00000035421	ENSGGOP00000045611	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.602
APAF1	CARD8	ENSGGOP00000035421	ENSGGOP00000000255	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 8.	0.720
APAF1	CASP10	ENSGGOP00000035421	ENSGGOP00000011996	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.796
APAF1	CASP2	ENSGGOP00000035421	ENSGGOP00000003520	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.866
APAF1	CASP9	ENSGGOP00000035421	ENSGGOP00000001932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSGGOP00000035421	ENSGGOP00000010692	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.799
APAF1	CRADD	ENSGGOP00000035421	ENSGGOP00000021798	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.568
APAF1	CYCS	ENSGGOP00000035421	ENSGGOP00000028382	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.999
APAF1	DIABLO	ENSGGOP00000035421	ENSGGOP00000005240	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.914
APAF1	ENSGGOP00000031130	ENSGGOP00000035421	ENSGGOP00000031130	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.633
APAF1	ENSGGOP00000033404	ENSGGOP00000035421	ENSGGOP00000033404	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.880
APAF1	ENSGGOP00000045267	ENSGGOP00000035421	ENSGGOP00000045267	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.720
APAF1	ENSGGOP00000046758	ENSGGOP00000035421	ENSGGOP00000046758	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 1; Belongs to the peptidase C14A family.	0.852
APAF1	FASLG	ENSGGOP00000035421	ENSGGOP00000024877	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand; Belongs to the tumor necrosis factor family.	0.588