18 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	PRAP1	Uncharacterized protein. (150 aa)
	RBM38	Uncharacterized protein. (158 aa)
	MUC1	Mucin 1, cell surface associated. (484 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	RPL26	Ribosomal protein L26. (145 aa)
	G3RPM5_GORGO	Promyelocytic leukemia. (834 aa)
	TRIAP1	TP53 regulated inhibitor of apoptosis 1. (76 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PLK3	Serine/threonine-protein kinase PLK. (673 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	ENSGGOP00000029067	KOW domain-containing protein. (138 aa)
	CDKN1B	Uncharacterized protein. (205 aa)
	ENSGGOP00000045437	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (575 aa)
	ENSGGOP00000036466	Checkpoint kinase 2. (529 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (472 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CDKN1A	ENSGGOP00000010144	ENSGGOP00000018811	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.608
ATM	CDKN1B	ENSGGOP00000010144	ENSGGOP00000049641	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.510
ATM	ENSGGOP00000036466	ENSGGOP00000010144	ENSGGOP00000036466	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 2.	0.997
ATM	PIDD1	ENSGGOP00000010144	ENSGGOP00000029519	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.716
CASP2	CRADD	ENSGGOP00000003520	ENSGGOP00000021798	Caspase 2; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.995
CASP2	PIDD1	ENSGGOP00000003520	ENSGGOP00000029519	Caspase 2; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.995
CDKN1A	ATM	ENSGGOP00000018811	ENSGGOP00000010144	Cyclin dependent kinase inhibitor 1A.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.608
CDKN1A	CDKN1B	ENSGGOP00000018811	ENSGGOP00000049641	Cyclin dependent kinase inhibitor 1A.	Uncharacterized protein.	0.994
CDKN1A	ENSGGOP00000036466	ENSGGOP00000018811	ENSGGOP00000036466	Cyclin dependent kinase inhibitor 1A.	Checkpoint kinase 2.	0.535
CDKN1A	RBM38	ENSGGOP00000018811	ENSGGOP00000007627	Cyclin dependent kinase inhibitor 1A.	Uncharacterized protein.	0.458
CDKN1B	ATM	ENSGGOP00000049641	ENSGGOP00000010144	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.510
CDKN1B	CDKN1A	ENSGGOP00000049641	ENSGGOP00000018811	Uncharacterized protein.	Cyclin dependent kinase inhibitor 1A.	0.994
CDKN1B	ENSGGOP00000036466	ENSGGOP00000049641	ENSGGOP00000036466	Uncharacterized protein.	Checkpoint kinase 2.	0.401
CRADD	CASP2	ENSGGOP00000021798	ENSGGOP00000003520	CASP2 and RIPK1 domain containing adaptor with death domain.	Caspase 2; Belongs to the peptidase C14A family.	0.995
CRADD	PIDD1	ENSGGOP00000021798	ENSGGOP00000029519	CASP2 and RIPK1 domain containing adaptor with death domain.	P53-induced death domain protein 1.	0.999
ENSGGOP00000036466	ATM	ENSGGOP00000036466	ENSGGOP00000010144	Checkpoint kinase 2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.997
ENSGGOP00000036466	CDKN1A	ENSGGOP00000036466	ENSGGOP00000018811	Checkpoint kinase 2.	Cyclin dependent kinase inhibitor 1A.	0.535
ENSGGOP00000036466	CDKN1B	ENSGGOP00000036466	ENSGGOP00000049641	Checkpoint kinase 2.	Uncharacterized protein.	0.401
ENSGGOP00000036466	PLK2	ENSGGOP00000036466	ENSGGOP00000012402	Checkpoint kinase 2.	Serine/threonine-protein kinase PLK.	0.576
ENSGGOP00000036466	PLK3	ENSGGOP00000036466	ENSGGOP00000020135	Checkpoint kinase 2.	Serine/threonine-protein kinase PLK.	0.594