12 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (890 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
	ATG10	Autophagy related 10. (220 aa)
	G3RPU5_GORGO	Uncharacterized protein; Belongs to the heat shock protein 70 family. (613 aa)
	CCDC47	Coiled-coil domain containing 47. (483 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	SELENOS	Uncharacterized protein. (218 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	TMCO1	Transmembrane and coiled-coil domains 1. (239 aa)
	PPP1R15B	Protein phosphatase 1 regulatory subunit 15B. (713 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L11	DDIT3	ENSGGOP00000047932	ENSGGOP00000001955	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.975
BCL2L11	EIF2AK3	ENSGGOP00000047932	ENSGGOP00000011491	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.441
BCL2L11	HSPA5	ENSGGOP00000047932	ENSGGOP00000023678	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.436
CCDC47	TMCO1	ENSGGOP00000018252	ENSGGOP00000049322	Coiled-coil domain containing 47.	Transmembrane and coiled-coil domains 1.	0.921
DDIT3	BCL2L11	ENSGGOP00000001955	ENSGGOP00000047932	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.975
DDIT3	EIF2AK3	ENSGGOP00000001955	ENSGGOP00000011491	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.676
DDIT3	G3RPU5_GORGO	ENSGGOP00000001955	ENSGGOP00000017817	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.602
DDIT3	HSPA5	ENSGGOP00000001955	ENSGGOP00000023678	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.695
EIF2AK3	BCL2L11	ENSGGOP00000011491	ENSGGOP00000047932	Eukaryotic translation initiation factor 2 alpha kinase 3.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.441
EIF2AK3	DDIT3	ENSGGOP00000011491	ENSGGOP00000001955	Eukaryotic translation initiation factor 2 alpha kinase 3.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.676
EIF2AK3	G3RPU5_GORGO	ENSGGOP00000011491	ENSGGOP00000017817	Eukaryotic translation initiation factor 2 alpha kinase 3.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.988
EIF2AK3	GSK3B	ENSGGOP00000011491	ENSGGOP00000007214	Eukaryotic translation initiation factor 2 alpha kinase 3.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.454
EIF2AK3	HSPA5	ENSGGOP00000011491	ENSGGOP00000023678	Eukaryotic translation initiation factor 2 alpha kinase 3.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.999
EIF2AK3	PPP1R15B	ENSGGOP00000011491	ENSGGOP00000001336	Eukaryotic translation initiation factor 2 alpha kinase 3.	Protein phosphatase 1 regulatory subunit 15B.	0.530
EIF2AK3	WFS1	ENSGGOP00000011491	ENSGGOP00000003431	Eukaryotic translation initiation factor 2 alpha kinase 3.	Wolframin ER transmembrane glycoprotein.	0.468
G3RPU5_GORGO	DDIT3	ENSGGOP00000017817	ENSGGOP00000001955	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.602
G3RPU5_GORGO	EIF2AK3	ENSGGOP00000017817	ENSGGOP00000011491	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.988
G3RPU5_GORGO	HSPA5	ENSGGOP00000017817	ENSGGOP00000023678	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.544
GSK3B	EIF2AK3	ENSGGOP00000007214	ENSGGOP00000011491	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.454
HSPA5	BCL2L11	ENSGGOP00000023678	ENSGGOP00000047932	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.436