37 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SREBF1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	ERLIN1	ER lipid raft associated 1. (348 aa)
	MBTPS1	Membrane bound transcription factor peptidase, site 1. (1052 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
	MBTPS2	Membrane bound transcription factor peptidase, site 2. (520 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1146 aa)
	ERLIN2	ER lipid raft associated 2. (339 aa)
	ATG10	Autophagy related 10. (220 aa)
	ATF6	Activating transcription factor 6. (670 aa)
	EIF2A	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (591 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	G3RPU5_GORGO	Uncharacterized protein; Belongs to the heat shock protein 70 family. (613 aa)
	CCDC47	Coiled-coil domain containing 47. (483 aa)
	G3RT31_GORGO	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	SELENOS	Uncharacterized protein. (218 aa)
	ENSGGOP00000032087	BZIP domain-containing protein. (342 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	PPP1R15B	Protein phosphatase 1 regulatory subunit 15B. (713 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (890 aa)
	CREBZF	CREB/ATF bZIP transcription factor. (358 aa)
	TMCO1	Transmembrane and coiled-coil domains 1. (239 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	ENSGGOP00000045173	Uncharacterized protein. (102 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1277 aa)
	QRICH1	Glutamine rich 1. (779 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	ATF6B	Activating transcription factor 6 beta. (703 aa)
	SCAP	SSD domain-containing protein. (338 aa)
	ENSGGOP00000033934	Uncharacterized protein. (318 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (600 aa)
	ENSGGOP00000033459	BZIP domain-containing protein. (350 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	ATF6	ENSGGOP00000009869	ENSGGOP00000013473	Activating transcription factor 4.	Activating transcription factor 6.	0.554
ATF4	ATF6B	ENSGGOP00000009869	ENSGGOP00000038216	Activating transcription factor 4.	Activating transcription factor 6 beta.	0.921
ATF4	DDIT3	ENSGGOP00000009869	ENSGGOP00000001955	Activating transcription factor 4.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.979
ATF4	EIF2AK3	ENSGGOP00000009869	ENSGGOP00000011491	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.958
ATF4	EIF2S1	ENSGGOP00000009869	ENSGGOP00000001580	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 subunit alpha.	0.956
ATF4	ENSGGOP00000032087	ENSGGOP00000009869	ENSGGOP00000032087	Activating transcription factor 4.	BZIP domain-containing protein.	0.543
ATF4	ENSGGOP00000033459	ENSGGOP00000009869	ENSGGOP00000033459	Activating transcription factor 4.	BZIP domain-containing protein.	0.545
ATF4	ENSGGOP00000033934	ENSGGOP00000009869	ENSGGOP00000033934	Activating transcription factor 4.	Uncharacterized protein.	0.545
ATF4	G3RPU5_GORGO	ENSGGOP00000009869	ENSGGOP00000017817	Activating transcription factor 4.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.656
ATF4	GSK3B	ENSGGOP00000009869	ENSGGOP00000007214	Activating transcription factor 4.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.911
ATF4	HSPA5	ENSGGOP00000009869	ENSGGOP00000023678	Activating transcription factor 4.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.768
ATF4	NFE2L2	ENSGGOP00000009869	ENSGGOP00000033500	Activating transcription factor 4.	Nuclear factor, erythroid 2 like 2.	0.618
ATF4	PPP1R15B	ENSGGOP00000009869	ENSGGOP00000001336	Activating transcription factor 4.	Protein phosphatase 1 regulatory subunit 15B.	0.407
ATF4	XBP1	ENSGGOP00000009869	ENSGGOP00000038457	Activating transcription factor 4.	BZIP domain-containing protein.	0.580
ATF6	ATF4	ENSGGOP00000013473	ENSGGOP00000009869	Activating transcription factor 6.	Activating transcription factor 4.	0.554
ATF6	ATF6B	ENSGGOP00000013473	ENSGGOP00000038216	Activating transcription factor 6.	Activating transcription factor 6 beta.	0.932
ATF6	BCL2L11	ENSGGOP00000013473	ENSGGOP00000047932	Activating transcription factor 6.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.442
ATF6	DDIT3	ENSGGOP00000013473	ENSGGOP00000001955	Activating transcription factor 6.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.986
ATF6	EIF2A	ENSGGOP00000013473	ENSGGOP00000015018	Activating transcription factor 6.	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	0.442
ATF6	EIF2AK3	ENSGGOP00000013473	ENSGGOP00000011491	Activating transcription factor 6.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.813