STRINGSTRING
MINK1 MINK1 G3QGC1_GORGO G3QGC1_GORGO G3QH29_GORGO G3QH29_GORGO MYD88 MYD88 G3QRE4_GORGO G3QRE4_GORGO PAFAH1B1 PAFAH1B1 G3QSG6_GORGO G3QSG6_GORGO G3QT76_GORGO G3QT76_GORGO IL1B IL1B FGF14 FGF14 ERCC6 ERCC6 NOX1 NOX1 MAPK8IP2 MAPK8IP2 WNT5A WNT5A TNFRSF19 TNFRSF19 NOD2 NOD2 RIPK2 RIPK2 SH2D3C SH2D3C TNFSF11 TNFSF11 MAP3K11 MAP3K11 SH2D3A SH2D3A MAP3K13 MAP3K13 ARHGEF6 ARHGEF6 DUSP9 DUSP9 IRAK1 IRAK1 NFKB1 NFKB1 G3RUC7_GORGO G3RUC7_GORGO CASR CASR TLR7 TLR7 MAP3K7 MAP3K7 MAP4K3 MAP4K3 IRAK4 IRAK4 NOD1 NOD1 MAP3K5 MAP3K5 MAP3K12 MAP3K12 MAPK9 MAPK9 G3S905_GORGO G3S905_GORGO DAXX DAXX TLR3 TLR3 NPHS1 NPHS1 G3SJH8_GORGO G3SJH8_GORGO ATF2 ATF2 LRRK2 LRRK2 FGF12 FGF12 CRKL CRKL GPS1 GPS1 ENSGGOP00000040207 ENSGGOP00000040207 ENSGGOP00000041058 ENSGGOP00000041058 MAP2K7 MAP2K7 STRADB STRADB ENSGGOP00000044534 ENSGGOP00000044534 SMAD3 SMAD3 ENSGGOP00000045400 ENSGGOP00000045400 ENSGGOP00000045863 ENSGGOP00000045863 STK3 STK3 ENSGGOP00000048050 ENSGGOP00000048050 ENSGGOP00000048129 ENSGGOP00000048129 MAPK8 MAPK8 HACD3 HACD3 MAPK10 MAPK10 ENSGGOP00000051849 ENSGGOP00000051849
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MINK1Misshapen like kinase 1. (1230 aa)
G3QGC1_GORGOMitogen-activated protein kinase kinase kinase. (884 aa)
G3QH29_GORGOG protein pathway suppressor 2. (327 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
G3QRE4_GORGOTribbles pseudokinase 1. (372 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
G3QSG6_GORGOMitogen-activated protein kinase kinase kinase 20. (780 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1493 aa)
NOX1NADPH oxidase 1. (564 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (847 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNFRSF19TNF receptor superfamily member 19. (419 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
G3RUC7_GORGOMitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (804 aa)
CASRCalcium sensing receptor. (1078 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
G3S905_GORGOUncharacterized protein. (134 aa)
DAXXDeath domain associated protein. (743 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1280 aa)
G3SJH8_GORGOUncharacterized protein. (596 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
CRKLUncharacterized protein. (201 aa)
GPS1G protein pathway suppressor 1. (486 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
ENSGGOP00000041058annotation not available (54 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
STRADBSTE20 related adaptor beta. (419 aa)
ENSGGOP00000044534Protein kinase domain-containing protein. (363 aa)
SMAD3Mothers against decapentaplegic homolog. (356 aa)
ENSGGOP00000045400Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (832 aa)
ENSGGOP00000045863Protein kinase domain-containing protein. (393 aa)
STK3Serine/threonine kinase 3. (519 aa)
ENSGGOP00000048050SH2 domain-containing protein. (132 aa)
ENSGGOP00000048129Caspase recruitment domain family member 9. (536 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (371 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
ENSGGOP00000051849Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (381 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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