(18 nodes) Regulation of hydrogen peroxide metabolic process network (Gorilla gorilla)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ENSGGOP00000034402	Uncharacterized protein. (278 aa)
	RAC1	Rac family small GTPase 1. (211 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
	MT3	Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	G3RSR8_GORGO	Haptoglobin; Belongs to the peptidase S1 family. (371 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (127 aa)
	ZNF205	Zinc finger protein 205. (554 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	HDAC6	Histone deacetylase 6. (1218 aa)
	ENSGGOP00000041746	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (400 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)
	DUOXA1	Dual oxidase maturation factor 1. (484 aa)
	DUOXA2	Dual oxidase maturation factor 2. (320 aa)
	ENSGGOP00000035220	Thioredoxin domain-containing protein. (136 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUOXA1	DUOXA2	ENSGGOP00000011437	ENSGGOP00000011427	Dual oxidase maturation factor 1.	Dual oxidase maturation factor 2.	0.475
DUOXA1	ENSGGOP00000034402	ENSGGOP00000011437	ENSGGOP00000034402	Dual oxidase maturation factor 1.	Uncharacterized protein.	0.571
DUOXA2	DUOXA1	ENSGGOP00000011427	ENSGGOP00000011437	Dual oxidase maturation factor 2.	Dual oxidase maturation factor 1.	0.475
DUOXA2	ENSGGOP00000034402	ENSGGOP00000011427	ENSGGOP00000034402	Dual oxidase maturation factor 2.	Uncharacterized protein.	0.449
ENSGGOP00000034402	DUOXA1	ENSGGOP00000034402	ENSGGOP00000011437	Uncharacterized protein.	Dual oxidase maturation factor 1.	0.571
ENSGGOP00000034402	DUOXA2	ENSGGOP00000034402	ENSGGOP00000011427	Uncharacterized protein.	Dual oxidase maturation factor 2.	0.449
ENSGGOP00000034402	RAC1	ENSGGOP00000034402	ENSGGOP00000034137	Uncharacterized protein.	Rac family small GTPase 1.	0.600
ENSGGOP00000034402	RAC2	ENSGGOP00000034402	ENSGGOP00000010349	Uncharacterized protein.	Rac family small GTPase 2.	0.843
FYN	RAC2	ENSGGOP00000007888	ENSGGOP00000010349	Tyrosine-protein kinase.	Rac family small GTPase 2.	0.947
FYN	SNCA	ENSGGOP00000007888	ENSGGOP00000027281	Tyrosine-protein kinase.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.755
HDAC6	SNCA	ENSGGOP00000049791	ENSGGOP00000027281	Histone deacetylase 6.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.580
PINK1	SNCA	ENSGGOP00000014209	ENSGGOP00000027281	PTEN induced kinase 1.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.762
RAC1	ENSGGOP00000034402	ENSGGOP00000034137	ENSGGOP00000034402	Rac family small GTPase 1.	Uncharacterized protein.	0.600
RAC1	RAC2	ENSGGOP00000034137	ENSGGOP00000010349	Rac family small GTPase 1.	Rac family small GTPase 2.	0.496
RAC2	ENSGGOP00000034402	ENSGGOP00000010349	ENSGGOP00000034402	Rac family small GTPase 2.	Uncharacterized protein.	0.843
RAC2	FYN	ENSGGOP00000010349	ENSGGOP00000007888	Rac family small GTPase 2.	Tyrosine-protein kinase.	0.947
RAC2	RAC1	ENSGGOP00000010349	ENSGGOP00000034137	Rac family small GTPase 2.	Rac family small GTPase 1.	0.496
SNCA	FYN	ENSGGOP00000027281	ENSGGOP00000007888	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	Tyrosine-protein kinase.	0.755
SNCA	HDAC6	ENSGGOP00000027281	ENSGGOP00000049791	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	Histone deacetylase 6.	0.580
SNCA	PINK1	ENSGGOP00000027281	ENSGGOP00000014209	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	PTEN induced kinase 1.	0.762