STRINGSTRING
G3SJS5_GORGO G3SJS5_GORGO PFKFB2 PFKFB2 GIT1 GIT1 FOXK1 FOXK1 PPP4R3B PPP4R3B DDB1 DDB1 ENSGGOP00000048202 ENSGGOP00000048202 FAM3A FAM3A IGF2 IGF2 NUPR1 NUPR1 PLEK PLEK ENSGGOP00000046735 ENSGGOP00000046735 ENSGGOP00000046516 ENSGGOP00000046516 ACACB ACACB NLN NLN RORC RORC DDIT4 DDIT4 ENSGGOP00000041843 ENSGGOP00000041843 RPTOR RPTOR PPARA PPARA BAD BAD PPP1R3C PPP1R3C ENSGGOP00000038823 ENSGGOP00000038823 PRKN PRKN ENSGGOP00000038029 ENSGGOP00000038029 SOGA1 SOGA1 C1QTNF6 C1QTNF6 AKT2 AKT2 NR3C1 NR3C1 GPLD1 GPLD1 PDK1 PDK1 PPP1R3B PPP1R3B CLK2 CLK2 PGP PGP IRS1 IRS1 ACTN3 ACTN3 SELENOS SELENOS ADIPOQ ADIPOQ SCARB2 SCARB2 ENSGGOP00000029053 ENSGGOP00000029053 G3SKI0_GORGO G3SKI0_GORGO PTH1R PTH1R LCMT1 LCMT1 C1QTNF1 C1QTNF1 SNCA SNCA G3SFH3_GORGO G3SFH3_GORGO HDAC4 HDAC4 DYRK2 DYRK2 GCG GCG MLST8 MLST8 G3SCI3_GORGO G3SCI3_GORGO RGN RGN CRY1 CRY1 PPP1R3G PPP1R3G MIDN MIDN PTPN2 PTPN2 NCOA2 NCOA2 G3S6B7_GORGO G3S6B7_GORGO FOXA2 FOXA2 PTH PTH STAT3 STAT3 EPM2AIP1 EPM2AIP1 G3RWG4_GORGO G3RWG4_GORGO KAT2B KAT2B SRC SRC INSR INSR G3RMA5_GORGO G3RMA5_GORGO TIGAR TIGAR NTSR1 NTSR1 G3RKN3_GORGO G3RKN3_GORGO FAM3C FAM3C G3RIH3_GORGO G3RIH3_GORGO PTK2B PTK2B PDK2 PDK2 IRS2 IRS2 OGT OGT SDHAF3 SDHAF3 TFF3 TFF3 SESN2 SESN2 G3REG2_GORGO G3REG2_GORGO PTAFR PTAFR SIRT7 SIRT7 BCKDK BCKDK GNMT GNMT AVPR1B AVPR1B PASK PASK GCKR GCKR G3RAB0_GORGO G3RAB0_GORGO GCGR GCGR PRKCE PRKCE G3R7J7_GORGO G3R7J7_GORGO ENPP1 ENPP1 STK11 STK11 SLC4A1 SLC4A1 MTOR MTOR MST1 MST1 MAS1 MAS1 RUBCNL RUBCNL G3R470_GORGO G3R470_GORGO SIRT1 SIRT1 G3R3C0_GORGO G3R3C0_GORGO IGFBP4 IGFBP4 PPARGC1A PPARGC1A ZNF692 ZNF692 G3R0P6_GORGO G3R0P6_GORGO SIRT6 SIRT6 LHCGR LHCGR EP300 EP300 FOXO1 FOXO1 MLYCD MLYCD INPP5K INPP5K GSK3B GSK3B SLC45A3 SLC45A3 GRB10 GRB10 SERPINA12 SERPINA12 PDK3 PDK3 FOXK2 FOXK2 G3QT42_GORGO G3QT42_GORGO FBP1 FBP1 PPP1R3A PPP1R3A CD244 CD244 KAT2A KAT2A USP7 USP7 ADIPOR1 ADIPOR1 WDR5 WDR5 IGF1 IGF1 GSK3A GSK3A DUSP12 DUSP12 NNMT NNMT POMC POMC DGAT2 DGAT2 GNB3 GNB3 KHK KHK G3QJF9_GORGO G3QJF9_GORGO PDK4 PDK4 PFKFB1 PFKFB1 SLC35B4 SLC35B4 FLCN FLCN GCK GCK LEP LEP PPP1R3F PPP1R3F RORA RORA ERFE ERFE LEPR LEPR P2RY1 P2RY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3SJS5_GORGOAcyl-CoA dehydrogenase medium chain. (454 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa)
GIT1GIT ArfGAP 1. (770 aa)
FOXK1Fork-head domain-containing protein. (623 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (849 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
ENSGGOP00000048202Uncharacterized protein. (210 aa)
FAM3AFamily with sequence similarity 3 member A. (244 aa)
IGF2Insulin like growth factor 2. (236 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
PLEKUncharacterized protein. (350 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
ENSGGOP00000046516Uncharacterized protein; Belongs to the peptidase C19 family. (410 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
NLNNeurolysin. (704 aa)
RORCRAR related orphan receptor C. (521 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
ENSGGOP00000041843G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1288 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
ENSGGOP00000038823Nuclear receptor corepressor 1. (2386 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ENSGGOP00000038029WD_REPEATS_REGION domain-containing protein. (276 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1608 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
CLK2CDC like kinase 2. (507 aa)
PGPUncharacterized protein. (122 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
SELENOSUncharacterized protein. (218 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
ENSGGOP00000029053cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
G3SKI0_GORGOUncharacterized protein. (1294 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (340 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
G3SFH3_GORGOUncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (133 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (597 aa)
GCGGlucagon. (180 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
G3SCI3_GORGOUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
RGNRegucalcin. (299 aa)
CRY1Cryptochrome circadian regulator 1. (623 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (358 aa)
MIDNMidnolin. (468 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (387 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
G3S6B7_GORGOPyrimidinergic receptor P2Y6. (328 aa)
FOXA2Forkhead box A2. (457 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
G3RWG4_GORGOUncharacterized protein. (331 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (820 aa)
SRCTyrosine-protein kinase. (542 aa)
INSRTyrosine-protein kinase receptor. (1347 aa)
G3RMA5_GORGOTyrosine-protein phosphatase non-receptor type. (415 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
G3RKN3_GORGOPhosphorylase kinase catalytic subunit gamma 2. (332 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
G3RIH3_GORGOADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
IRS2Insulin receptor substrate 2. (1220 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
SDHAF3Uncharacterized protein. (125 aa)
TFF3Trefoil factor 3. (94 aa)
SESN2Sestrin 2. (480 aa)
G3REG2_GORGOGlutamic--pyruvic transaminase. (496 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
SIRT7Sirtuin 7. (400 aa)
BCKDKProtein-serine/threonine kinase. (413 aa)
GNMTGlycine N-methyltransferase. (295 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
PASKPAS domain containing serine/threonine kinase. (1322 aa)
GCKRGlucokinase regulator. (625 aa)
G3RAB0_GORGOCBFA2/RUNX1 partner transcriptional co-repressor 3. (653 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (480 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
G3R7J7_GORGOCytochrome c oxidase copper chaperone COX11. (276 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (896 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
SLC4A1Anion exchange protein. (921 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
RUBCNLRubicon like autophagy enhancer. (663 aa)
G3R470_GORGODiacylglycerol kinase. (775 aa)
SIRT1Sirtuin 1. (751 aa)
G3R3C0_GORGOSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ZNF692Zinc finger protein 692. (524 aa)
G3R0P6_GORGOSolute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (553 aa)
SIRT6Sirtuin 6. (355 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
EP300E1A binding protein p300. (2416 aa)
FOXO1Forkhead box O1. (655 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
PDK3Protein-serine/threonine kinase. (423 aa)
FOXK2Forkhead box K2. (568 aa)
G3QT42_GORGOC1q and TNF related 12. (302 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
CD244CD244 molecule. (365 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
WDR5WD repeat domain 5. (334 aa)
IGF1IlGF domain-containing protein. (196 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
DUSP12Dual specificity phosphatase 12. (340 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
POMCProopiomelanocortin. (267 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
GNB3G protein subunit beta 3. (340 aa)
KHKKetohexokinase. (298 aa)
G3QJF9_GORGOCAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
SLC35B4Solute carrier family 35 member B4. (331 aa)
FLCNFolliculin. (579 aa)
GCKPhosphotransferase. (466 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (644 aa)
RORARAR related orphan receptor A. (555 aa)
ERFEErythroferrone. (353 aa)
LEPRLeptin receptor. (1154 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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