(64 nodes) Potassium channel regulator activity network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	KCNAB2	Aldo_ket_red domain-containing protein. (243 aa)
	KCNS3	Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
	SGK1	Non-specific serine/threonine protein kinase. (526 aa)
	KCNMB3	Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (279 aa)
	FLNA	Filamin A. (2647 aa)
	SGK2	Serum/glucocorticoid regulated kinase 2. (429 aa)
	LRRC26	Leucine rich repeat containing 26. (334 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	ADRB2	Adrenoceptor beta 2. (413 aa)
	KCNAB3	Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (404 aa)
	G3QUJ2_GORGO	Potassium voltage-gated channel interacting protein 2. (285 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
	PIAS3	Protein inhibitor of activated STAT 3. (628 aa)
	G3QWG8_GORGO	Potassium voltage-gated channel interacting protein 1. (241 aa)
	LRRC52	Leucine rich repeat containing 52. (313 aa)
	AKAP9	A-kinase anchoring protein 9. (3907 aa)
	LRRC55	Leucine rich repeat containing 55. (341 aa)
	KCNV1	Potassium voltage-gated channel modifier subfamily V member 1; Belongs to the potassium channel family. (502 aa)
	KCNE5	Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
	KCNIP3	Potassium voltage-gated channel interacting protein 3. (256 aa)
	AMIGO3	Adhesion molecule with Ig like domain 3. (504 aa)
	KCNMB4	Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2175 aa)
	KCNMB2	KcnmB2_inactiv domain-containing protein. (235 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1243 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
	CNTD1	Uncharacterized protein. (247 aa)
	G3S0S1_GORGO	Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (581 aa)
	PDZD4	PDZ domain containing 4. (775 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
	LRRC38	Leucine rich repeat containing 38. (294 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
	AMIGO1	Adhesion molecule with Ig like domain 1. (493 aa)
	G3SEZ6_GORGO	Uncharacterized protein. (104 aa)
	G3SFH3_GORGO	Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (133 aa)
	G3SHM7_GORGO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (210 aa)
	ENSGGOP00000028898	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (195 aa)
	ENSGGOP00000029053	cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
	ABCC9	ATP binding cassette subfamily C member 9. (1549 aa)
	ENSGGOP00000031578	Rad60-SLD domain-containing protein. (84 aa)
	ENSGGOP00000032522	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (203 aa)
	NEDD4L	Uncharacterized protein. (1178 aa)
	KCNS1	Potassium voltage-gated channel subfamily S member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. (526 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	RASA1	RAS p21 protein activator 1. (1047 aa)
	ENSGGOP00000041589	EF-hand domain-containing protein. (70 aa)
	DPP6	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (865 aa)
	ENSGGOP00000042059	Ubiquitin-like domain-containing protein. (146 aa)
	KCNIP4	EF-hand domain-containing protein. (143 aa)
	ENSGGOP00000045869	Rad60-SLD domain-containing protein. (95 aa)
	DPP10	Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (796 aa)
	ENSGGOP00000046735	Non-specific serine/threonine protein kinase. (524 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1800 aa)
	ENSGGOP00000047763	WNK lysine deficient protein kinase 1. (2786 aa)
	SLC5A3	Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)
	ENSGGOP00000048879	Uncharacterized protein. (163 aa)
	AMIGO2	Adhesion molecule with Ig like domain 2. (522 aa)
	ENSGGOP00000051267	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (419 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC9	KCNE3	ENSGGOP00000029439	ENSGGOP00000029427	ATP binding cassette subfamily C member 9.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.475
ABCC9	KCNE5	ENSGGOP00000029439	ENSGGOP00000008416	ATP binding cassette subfamily C member 9.	Potassium voltage-gated channel subfamily E regulatory subunit 5.	0.483
ADRB2	CAV3	ENSGGOP00000005329	ENSGGOP00000000134	Adrenoceptor beta 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.633
ADRB2	ENSGGOP00000046735	ENSGGOP00000005329	ENSGGOP00000046735	Adrenoceptor beta 2.	Non-specific serine/threonine protein kinase.	0.514
ADRB2	KCNMB1	ENSGGOP00000005329	ENSGGOP00000007004	Adrenoceptor beta 2.	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	0.550
ADRB2	WNK4	ENSGGOP00000005329	ENSGGOP00000015659	Adrenoceptor beta 2.	WNK lysine deficient protein kinase 4.	0.687
AKAP9	KCNE2	ENSGGOP00000007279	ENSGGOP00000009319	A-kinase anchoring protein 9.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.574
AKAP9	KCNE3	ENSGGOP00000007279	ENSGGOP00000029427	A-kinase anchoring protein 9.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.555
AKAP9	KCNE5	ENSGGOP00000007279	ENSGGOP00000008416	A-kinase anchoring protein 9.	Potassium voltage-gated channel subfamily E regulatory subunit 5.	0.432
AMIGO2	DLG1	ENSGGOP00000050182	ENSGGOP00000004830	Adhesion molecule with Ig like domain 2.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.403
CAV1	CAV3	ENSGGOP00000022437	ENSGGOP00000000134	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.929
CAV1	ENSGGOP00000046735	ENSGGOP00000022437	ENSGGOP00000046735	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Non-specific serine/threonine protein kinase.	0.440
CAV3	ADRB2	ENSGGOP00000000134	ENSGGOP00000005329	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adrenoceptor beta 2.	0.633
CAV3	CAV1	ENSGGOP00000000134	ENSGGOP00000022437	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.929
CAV3	DLG1	ENSGGOP00000000134	ENSGGOP00000004830	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.713
CAV3	ENSGGOP00000046735	ENSGGOP00000000134	ENSGGOP00000046735	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Non-specific serine/threonine protein kinase.	0.522
CAV3	G3QWG8_GORGO	ENSGGOP00000000134	ENSGGOP00000007126	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel interacting protein 1.	0.496
CAV3	KCNE2	ENSGGOP00000000134	ENSGGOP00000009319	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.598
CAV3	KCNIP3	ENSGGOP00000000134	ENSGGOP00000009619	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel interacting protein 3.	0.515
DLG1	AMIGO2	ENSGGOP00000004830	ENSGGOP00000050182	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Adhesion molecule with Ig like domain 2.	0.403