STRINGSTRING
G3SC62_GORGO G3SC62_GORGO BRAF BRAF LSM1 LSM1 ASPM ASPM G3S841_GORGO G3S841_GORGO LIG4 LIG4 MED15 MED15 FUT10 FUT10 G3RZJ6_GORGO G3RZJ6_GORGO SALL4 SALL4 ZIC3 ZIC3 JAG1 JAG1 LDB2 LDB2 EIF4E EIF4E VPS72 VPS72 ENSGGOP00000050849 ENSGGOP00000050849 FZD7 FZD7 ENSGGOP00000050356 ENSGGOP00000050356 SFRP1 SFRP1 CTNNB1 CTNNB1 MED27 MED27 MED21 MED21 ENSGGOP00000046477 ENSGGOP00000046477 LIN28A LIN28A MED6 MED6 ENSGGOP00000051675 ENSGGOP00000051675 RBPJ RBPJ PAF1 PAF1 IGF2BP1 IGF2BP1 ENSGGOP00000041968 ENSGGOP00000041968 FAXC FAXC ENSGGOP00000040146 ENSGGOP00000040146 PHF19 PHF19 TBX3 TBX3 SS18 SS18 ENSGGOP00000037735 ENSGGOP00000037735 ENSGGOP00000037204 ENSGGOP00000037204 WNT9B WNT9B TPT1 TPT1 ENSGGOP00000036146 ENSGGOP00000036146 ENSGGOP00000035259 ENSGGOP00000035259 ENSGGOP00000034312 ENSGGOP00000034312 METTL14 METTL14 CDC73 CDC73 ENSGGOP00000031387 ENSGGOP00000031387 ENSGGOP00000030855 ENSGGOP00000030855 ZNF358 ZNF358 MED12 MED12 ENSGGOP00000028943 ENSGGOP00000028943 ESRRB ESRRB CDX2 CDX2 KLF4 KLF4 LIF LIF G3QCT9_GORGO G3QCT9_GORGO CUL4A CUL4A KDM4C KDM4C MED28 MED28 MTF2 MTF2 ZFP36L2 ZFP36L2 SRRT SRRT G3QHX9_GORGO G3QHX9_GORGO LDB1 LDB1 REST REST MED7 MED7 NODAL NODAL G3QLT5_GORGO G3QLT5_GORGO BMPR1A BMPR1A TRIM8 TRIM8 FGF10 FGF10 G3QQE7_GORGO G3QQE7_GORGO DLL1 DLL1 YAP1 YAP1 METTL3 METTL3 GATA2 GATA2 HESX1 HESX1 SPI1 SPI1 ASCL2 ASCL2 FOXO1 FOXO1 BCL9L BCL9L EOMES EOMES HES1 HES1 SIX2 SIX2 PIWIL2 PIWIL2 MED30 MED30 BCL9 BCL9 SETD6 SETD6 TUT4 TUT4 NOTCH1 NOTCH1 MCPH1 MCPH1 NR2E1 NR2E1 FGF4 FGF4 PRRX1 PRRX1 G3R439_GORGO G3R439_GORGO G3R4L4_GORGO G3R4L4_GORGO PRDM14 PRDM14 CTR9 CTR9 GNL3 GNL3 TET1 TET1 MMP24 MMP24 SOX4 SOX4 PELO PELO WNT7A WNT7A NKAP NKAP NANOS2 NANOS2 RTF1 RTF1 G3RDK5_GORGO G3RDK5_GORGO TCF15 TCF15 PROX1 PROX1 KLF10 KLF10 PADI4 PADI4 KIT KIT SMC5 SMC5 SOX9 SOX9 G3RP17_GORGO G3RP17_GORGO G3RQI9_GORGO G3RQI9_GORGO MED14 MED14 STAT3 STAT3 G3SIC3_GORGO G3SIC3_GORGO RAF1 RAF1 DIS3L2 DIS3L2 NIPBL NIPBL G3SD87_GORGO G3SD87_GORGO FANCC FANCC CDH2 CDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3SC62_GORGOPericentriolar material 1. (1966 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
G3S841_GORGOUncharacterized protein. (245 aa)
LIG4DNA ligase. (911 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (783 aa)
FUT10Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family. (482 aa)
G3RZJ6_GORGOLEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
ZIC3Zic family member 3. (466 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LDB2LIM domain binding 2. (373 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (212 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
ENSGGOP00000050849Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (220 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSGGOP00000050356Replication timing regulatory factor 1. (2281 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CTNNB1Catenin beta 1. (781 aa)
MED27Mediator complex subunit 27. (311 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (159 aa)
ENSGGOP00000046477Uncharacterized protein. (433 aa)
LIN28ALin-28 homolog A. (209 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
ENSGGOP00000051675Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (174 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (533 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ENSGGOP00000041968TCTP domain-containing protein; Belongs to the TCTP family. (198 aa)
FAXCFailed axon connections homolog, metaxin like GST domain containing. (356 aa)
ENSGGOP00000040146CCHC-type domain-containing protein. (203 aa)
PHF19PHD finger protein 19. (599 aa)
TBX3T-box transcription factor 3. (743 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (418 aa)
ENSGGOP00000037735Uncharacterized protein. (471 aa)
ENSGGOP00000037204Uncharacterized protein. (433 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
TPT1Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (197 aa)
ENSGGOP00000036146TCTP domain-containing protein; Belongs to the TCTP family. (144 aa)
ENSGGOP00000035259Structural maintenance of chromosomes 1A. (1096 aa)
ENSGGOP00000034312FA complementation group D2. (1390 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
CDC73Cell division cycle 73. (452 aa)
ENSGGOP00000031387Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
ENSGGOP00000030855Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (119 aa)
ZNF358Zinc finger protein 358. (556 aa)
MED12Mediator complex subunit 12. (2177 aa)
ENSGGOP00000028943TCTP domain-containing protein; Belongs to the TCTP family. (221 aa)
ESRRBEstrogen related receptor beta. (508 aa)
CDX2Caudal type homeobox 2. (313 aa)
KLF4Kruppel like factor 4. (479 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
G3QCT9_GORGOLow-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1590 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
KDM4CLysine demethylase 4C. (1056 aa)
MED28Mediator complex subunit 28. (178 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
SRRTSerrate, RNA effector molecule. (883 aa)
G3QHX9_GORGOUncharacterized protein. (462 aa)
LDB1LIM domain binding 1. (411 aa)
RESTRE1 silencing transcription factor. (1081 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
NODALNodal growth differentiation factor. (347 aa)
G3QLT5_GORGOEukaryotic translation initiation factor 4E nuclear import factor 1. (963 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TRIM8Tripartite motif containing 8. (551 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
G3QQE7_GORGOHook microtubule tethering protein 3. (628 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
YAP1Uncharacterized protein. (326 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
GATA2GATA binding protein 2. (480 aa)
HESX1HESX homeobox 1. (185 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
FOXO1Forkhead box O1. (655 aa)
BCL9LBCL9 like. (1499 aa)
EOMESEomesodermin. (705 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SIX2SIX homeobox 2. (291 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (623 aa)
MED30Mediator complex subunit 30. (178 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
SETD6SET domain-containing protein. (370 aa)
TUT4Uncharacterized protein. (340 aa)
NOTCH1Uncharacterized protein. (1606 aa)
MCPH1Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). (785 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PRRX1Paired related homeobox 1. (245 aa)
G3R439_GORGOHes family bHLH transcription factor 5. (165 aa)
G3R4L4_GORGOSKI proto-oncogene. (700 aa)
PRDM14PR/SET domain 14. (571 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
GNL3G protein nucleolar 3. (549 aa)
TET1Tet methylcytosine dioxygenase 1. (2136 aa)
MMP24Matrix metallopeptidase 24. (647 aa)
SOX4Transcription factor SOX. (444 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (345 aa)
NKAPNFKB activating protein. (416 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
G3RDK5_GORGOHomeobox domain-containing protein. (166 aa)
TCF15Transcription factor 15. (198 aa)
PROX1Prospero homeobox 1. (737 aa)
KLF10Kruppel like factor 10. (479 aa)
PADI4Peptidyl arginine deiminase 4. (663 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
SOX9SRY-box transcription factor 9. (509 aa)
G3RP17_GORGOStructural maintenance of chromosomes protein. (1175 aa)
G3RQI9_GORGOWW domain-containing protein. (413 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1418 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
G3SIC3_GORGOUncharacterized protein. (337 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (811 aa)
NIPBLNipped-B protein. (2804 aa)
G3SD87_GORGODEAD-box helicase 6; Belongs to the DEAD box helicase family. (434 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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