STRINGSTRING
G3QGD7_GORGO G3QGD7_GORGO TGFB3 TGFB3 TACR1 TACR1 PHOSPHO1 PHOSPHO1 KREMEN1 KREMEN1 TXLNG TXLNG DKK1 DKK1 G3QJF9_GORGO G3QJF9_GORGO FGF23 FGF23 INTU INTU SOST SOST SRGN SRGN BMPR1A BMPR1A G3QMJ4_GORGO G3QMJ4_GORGO G3QPK5_GORGO G3QPK5_GORGO G3QQZ6_GORGO G3QQZ6_GORGO EGR2 EGR2 G3QRP1_GORGO G3QRP1_GORGO ADRB2 ADRB2 GDF10 GDF10 PHOSPHO2 PHOSPHO2 G3QU00_GORGO G3QU00_GORGO FBN2 FBN2 OSR2 OSR2 CCN1 CCN1 KL KL WNT5A WNT5A TFAP2A TFAP2A PTGER4 PTGER4 MATN1 MATN1 SCUBE2 SCUBE2 COMP COMP LTF LTF TRPM4 TRPM4 SIX2 SIX2 CHSY1 CHSY1 RXRB RXRB NOTCH1 NOTCH1 SMAD7 SMAD7 ADGRV1 ADGRV1 ENPP1 ENPP1 WNT10B WNT10B PBX1 PBX1 DDR2 DDR2 ATRAID ATRAID G3R859_GORGO G3R859_GORGO BMPR1B BMPR1B ALOX5 ALOX5 G3RB41_GORGO G3RB41_GORGO G3RD86_GORGO G3RD86_GORGO PKDCC PKDCC CALCA CALCA ATP2B1 ATP2B1 BCOR BCOR BMP4 BMP4 G3RG63_GORGO G3RG63_GORGO G3RG93_GORGO G3RG93_GORGO PTK2B PTK2B ACVR2A ACVR2A CSF1 CSF1 VDR VDR SOX9 SOX9 TPH1 TPH1 LRP4 LRP4 G3RRP1_GORGO G3RRP1_GORGO GATA1 GATA1 ECM1 ECM1 PTH PTH BGLAP BGLAP BMP2 BMP2 OSR1 OSR1 MAPK3 MAPK3 MDK MDK G3S6C5_GORGO G3S6C5_GORGO ENSGGOP00000024523 ENSGGOP00000024523 LTBP3 LTBP3 RFLNB RFLNB TMEM119 TMEM119 NIPBL NIPBL TGFB1 TGFB1 STATH STATH BMP2K BMP2K HIF1A HIF1A G3SJA5_GORGO G3SJA5_GORGO PTPN11 PTPN11 S1PR1 S1PR1 NOTUM NOTUM ACTN3 ACTN3 CALCR CALCR ENSGGOP00000031261 ENSGGOP00000031261 SGMS2 SGMS2 RFLNA RFLNA NELL1 NELL1 ENSGGOP00000034163 ENSGGOP00000034163 ENSGGOP00000036103 ENSGGOP00000036103 ENSGGOP00000036695 ENSGGOP00000036695 ENSGGOP00000037095 ENSGGOP00000037095 OMD OMD GPM6B GPM6B ENSGGOP00000037389 ENSGGOP00000037389 ENSGGOP00000037657 ENSGGOP00000037657 BMPR2 BMPR2 MAPK1 MAPK1 NBR1 NBR1 RXRA RXRA ACVR1 ACVR1 FAM20C FAM20C ENSGGOP00000042445 ENSGGOP00000042445 RBPJ RBPJ ENSGGOP00000042965 ENSGGOP00000042965 PTN PTN SMAD3 SMAD3 WNT4 WNT4 FZD9 FZD9 ENSGGOP00000049072 ENSGGOP00000049072 SFRP1 SFRP1 AHSG AHSG RUNX2 RUNX2 ANO6 ANO6 CCR1 CCR1 ANKH ANKH SOX11 SOX11 ZBTB16 ZBTB16 BCL2 BCL2 BMP6 BMP6 TENT5A TENT5A ESRRA ESRRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QGD7_GORGOCytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (473 aa)
TXLNGTaxilin gamma. (524 aa)
DKK1Dickkopf-related protein 1. (266 aa)
G3QJF9_GORGOCAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
INTUInturned planar cell polarity protein. (942 aa)
SOSTSclerostin. (213 aa)
SRGNSerglycin. (160 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
G3QMJ4_GORGOBone morphogenetic protein 7. (380 aa)
G3QPK5_GORGOTransforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
G3QQZ6_GORGOKremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
EGR2Early growth response 2. (476 aa)
G3QRP1_GORGOUncharacterized protein. (107 aa)
ADRB2Adrenoceptor beta 2. (413 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
G3QU00_GORGOUncharacterized protein. (567 aa)
FBN2Fibrillin 2. (2866 aa)
OSR2Odd-skipped related transciption factor 2. (422 aa)
CCN1Cellular communication network factor 1. (381 aa)
KLUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (739 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
MATN1Matrilin 1. (496 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (996 aa)
COMPCartilage oligomeric matrix protein. (686 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1292 aa)
SIX2SIX homeobox 2. (291 aa)
CHSY1Hexosyltransferase. (802 aa)
RXRBRetinoid X receptor beta. (537 aa)
NOTCH1Uncharacterized protein. (1606 aa)
SMAD7MH2 domain-containing protein. (211 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (896 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PBX1PBX homeobox 1. (430 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
ATRAIDEGF-like domain-containing protein. (348 aa)
G3R859_GORGOUncharacterized protein. (100 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ALOX5Arachidonate 5-lipoxygenase. (678 aa)
G3RB41_GORGOMothers against decapentaplegic homolog. (435 aa)
G3RD86_GORGOP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (412 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
BCORBCL6 corepressor. (1755 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
G3RG63_GORGOISG15 ubiquitin like modifier. (165 aa)
G3RG93_GORGODehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
VDRVitamin D receptor. (477 aa)
SOX9SRY-box transcription factor 9. (509 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
LRP4LDL receptor related protein 4. (1947 aa)
G3RRP1_GORGOUncharacterized protein. (270 aa)
GATA1GATA binding protein 1. (413 aa)
ECM1Uncharacterized protein. (540 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MDKMidkine. (143 aa)
G3S6C5_GORGOCTCK domain-containing protein. (143 aa)
ENSGGOP00000024523annotation not available (408 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1285 aa)
RFLNBRefilin B. (144 aa)
TMEM119Transmembrane protein 119. (283 aa)
NIPBLNipped-B protein. (2804 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STATHStatherin. (62 aa)
BMP2KBMP2 inducible kinase. (1153 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
G3SJA5_GORGOSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (541 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (461 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
ENSGGOP00000031261Myocyte enhancer factor 2C. (483 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
RFLNAUncharacterized protein. (178 aa)
NELL1Neural EGFL like 1. (838 aa)
ENSGGOP00000034163Uncharacterized protein. (485 aa)
ENSGGOP00000036103Uncharacterized protein. (509 aa)
ENSGGOP00000036695Uncharacterized protein. (366 aa)
ENSGGOP00000037095Uncharacterized protein. (575 aa)
OMDOsteomodulin. (421 aa)
GPM6BGlycoprotein M6B. (305 aa)
ENSGGOP00000037389Uncharacterized protein. (107 aa)
ENSGGOP00000037657Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
NBR1NBR1 autophagy cargo receptor. (984 aa)
RXRARetinoid X receptor alpha. (463 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
FAM20CFam20C domain-containing protein. (296 aa)
ENSGGOP00000042445Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
ENSGGOP00000042965GDNF domain-containing protein. (207 aa)
PTNPleiotrophin. (172 aa)
SMAD3Mothers against decapentaplegic homolog. (356 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
AHSGAlpha 2-HS glycoprotein. (367 aa)
RUNX2Runt domain-containing protein. (541 aa)
ANO6Anoctamin. (921 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (492 aa)
SOX11Transcription factor SOX. (441 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
TENT5ATerminal nucleotidyltransferase 5A. (466 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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