(51 nodes) Osteoclast differentiation network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	LRRK1	Leucine rich repeat kinase 1. (2015 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (470 aa)
	EFNA2	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (241 aa)
	ENSGGOP00000051960	Annexin. (330 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
	SH3PXD2A	SH3 and PX domains 2A. (1133 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	CD109	CD109 molecule. (1446 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1054 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NF1	Neurofibromin 1. (2811 aa)
	TFRC	Transferrin receptor. (760 aa)
	CD81	Tetraspanin. (260 aa)
	EPHA2	EPH receptor A2. (876 aa)
	OSTM1	Osteoclastogenesis associated transmembrane protein 1. (293 aa)
	ANXA2	Annexin. (357 aa)
	G3R4E1_GORGO	Forkhead box P1. (693 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	SBNO2	Strawberry notch homolog 2. (1319 aa)
	GAB4	GRB2 associated binding protein family member 4. (575 aa)
	IL20	Interleukin 20. (176 aa)
	G3RCB2_GORGO	ATPase H+ transporting accessory protein 1. (446 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	IREB2	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	IAPP	Islet amyloid polypeptide. (89 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	OCSTAMP	Osteoclast stimulatory transmembrane protein. (565 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	SNX10	Sorting nexin 10. (201 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CALCR	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
	ENSGGOP00000032524	Annexin. (318 aa)
	ENSGGOP00000032619	cAMP responsive element binding protein 1. (341 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	MITF	Melanocyte inducing transcription factor. (526 aa)
	CCN4	Cellular communication network factor 4. (368 aa)
	FAM20C	Fam20C domain-containing protein. (296 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	ENSGGOP00000045574	Uncharacterized protein. (316 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (616 aa)
	ENSGGOP00000049072	Protein kinase domain-containing protein. (296 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA2	CD81	ENSGGOP00000009512	ENSGGOP00000007419	Annexin.	Tetraspanin.	0.411
CALCR	DCSTAMP	ENSGGOP00000030967	ENSGGOP00000001947	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Dendrocyte expressed seven transmembrane protein.	0.521
CALCR	FOS	ENSGGOP00000030967	ENSGGOP00000000519	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.431
CALCR	IAPP	ENSGGOP00000030967	ENSGGOP00000018203	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Islet amyloid polypeptide.	0.997
CALCR	TNFSF11	ENSGGOP00000030967	ENSGGOP00000010907	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Tumor necrosis factor ligand superfamily member.	0.576
CCN4	CTNNB1	ENSGGOP00000039962	ENSGGOP00000048898	Cellular communication network factor 4.	Catenin beta 1.	0.443
CD109	CD81	ENSGGOP00000004013	ENSGGOP00000007419	CD109 molecule.	Tetraspanin.	0.461
CD109	TGFB1	ENSGGOP00000004013	ENSGGOP00000026415	CD109 molecule.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.681
CD81	ANXA2	ENSGGOP00000007419	ENSGGOP00000009512	Tetraspanin.	Annexin.	0.411
CD81	CD109	ENSGGOP00000007419	ENSGGOP00000004013	Tetraspanin.	CD109 molecule.	0.461
CD81	ENSGGOP00000051960	ENSGGOP00000007419	ENSGGOP00000051960	Tetraspanin.	Annexin.	0.411
CD81	EPHA2	ENSGGOP00000007419	ENSGGOP00000007795	Tetraspanin.	EPH receptor A2.	0.801
CD81	TFRC	ENSGGOP00000007419	ENSGGOP00000007085	Tetraspanin.	Transferrin receptor.	0.513
CSF1	CSF1R	ENSGGOP00000015814	ENSGGOP00000016943	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.999
CSF1	DCSTAMP	ENSGGOP00000015814	ENSGGOP00000001947	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Dendrocyte expressed seven transmembrane protein.	0.443
CSF1	FAM20C	ENSGGOP00000015814	ENSGGOP00000041784	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Fam20C domain-containing protein.	0.521
CSF1	FOS	ENSGGOP00000015814	ENSGGOP00000000519	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Fos proto-oncogene, AP-1 transcription factor subunit.	0.516
CSF1	G3QT76_GORGO	ENSGGOP00000015814	ENSGGOP00000005887	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.607
CSF1	SRC	ENSGGOP00000015814	ENSGGOP00000018321	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tyrosine-protein kinase.	0.719
CSF1	TGFB1	ENSGGOP00000015814	ENSGGOP00000026415	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.586