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MYD88 MYD88 NOS3 NOS3 IRAK1 IRAK1 CCL3 CCL3 MALT1 MALT1 TLR4 TLR4 ENSGGOP00000021036 ENSGGOP00000021036 MAPK3 MAPK3 LY86 LY86 TGFB1 TGFB1 PLCG2 PLCG2 HCK HCK G3SJS6_GORGO G3SJS6_GORGO MTDH MTDH ENSGGOP00000037129 ENSGGOP00000037129 MAPK1 MAPK1 ENSGGOP00000043564 ENSGGOP00000043564 SCARB1 SCARB1 ENSGGOP00000046735 ENSGGOP00000046735 ENSGGOP00000049072 ENSGGOP00000049072 BCL10 BCL10 IL18 IL18 LY96 LY96 PTAFR PTAFR LYN LYN PRKCE PRKCE RIPK2 RIPK2 CD14 CD14 NFKBIA NFKBIA CD6 CD6 CD180 CD180 G3QXA0_GORGO G3QXA0_GORGO G3QX51_GORGO G3QX51_GORGO G3QX42_GORGO G3QX42_GORGO G3QUW7_GORGO G3QUW7_GORGO SPI1 SPI1 IL1B IL1B G3QT76_GORGO G3QT76_GORGO G3QMP2_GORGO G3QMP2_GORGO G3QHL6_GORGO G3QHL6_GORGO CCL2 CCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
NOS3Nitric oxide synthase 3. (997 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
CCL3C-C motif chemokine. (92 aa)
MALT1MALT1 paracaspase. (824 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
ENSGGOP00000021036annotation not available (839 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
LY86Lymphocyte antigen 86. (162 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
HCKTyrosine-protein kinase. (526 aa)
G3SJS6_GORGOBPI fold containing family C. (466 aa)
MTDHMetadherin. (612 aa)
ENSGGOP00000037129Uncharacterized protein. (233 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSGGOP00000043564Interferon regulatory factor 3. (452 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
BCL10CARD domain-containing protein. (316 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LY96Lymphocyte antigen 96. (160 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
LYNTyrosine-protein kinase. (512 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CD6CD6 molecule. (675 aa)
CD180CD180 molecule. (661 aa)
G3QXA0_GORGOSCY domain-containing protein. (53 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
G3QX42_GORGOBactericidal permeability increasing protein. (487 aa)
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G3QMP2_GORGOProtein tyrosine phosphatase non-receptor type 22. (693 aa)
G3QHL6_GORGOInterleukin 1 receptor associated kinase 2. (538 aa)
CCL2C-C motif chemokine. (99 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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