(41 nodes) Positive regulation of telomere maintenance via telomerase network (Gorilla gorilla)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	CCT6A	Chaperonin containing TCP1 subunit 6A. (531 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (519 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	MAPK15	Mitogen-activated protein kinase. (544 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	CCT8	Chaperonin containing TCP1 subunit 8. (548 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	FBXO4	F-box protein 4. (387 aa)
	NEK2	NIMA related kinase 2. (445 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	NAF1	Nuclear assembly factor 1 ribonucleoprotein. (494 aa)
	ENSGGOP00000051819	Protein kinase domain-containing protein. (421 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
	ENSGGOP00000036928	Uncharacterized protein. (504 aa)
	ENSGGOP00000036793	Uncharacterized protein. (453 aa)
	ENSGGOP00000034799	ACD shelterin complex subunit and telomerase recruitment factor. (475 aa)
	ENSGGOP00000029415	Uncharacterized protein. (76 aa)
	G3SKQ6_GORGO	Uncharacterized protein. (563 aa)
	G3SI52_GORGO	Uncharacterized protein. (435 aa)
	CCT4	T-complex protein 1 subunit delta. (501 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (541 aa)
	MAPK3	Mitogen-activated protein kinase. (322 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1608 aa)
	PARN	Poly(A)-specific ribonuclease. (621 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (514 aa)
	PKIB	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (85 aa)
	POT1	Protection of telomeres 1. (634 aa)
	TCP1	T-complex 1. (556 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	ENSGGOP00000041124	annotation not available (563 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (435 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	ENSGGOP00000045635	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (161 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (490 aa)
	ENSGGOP00000047900	Uncharacterized protein. (453 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSGGOP00000010144	ENSGGOP00000038006	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.995
ATM	CTNNB1	ENSGGOP00000010144	ENSGGOP00000048898	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta 1.	0.487
ATM	MAPK3	ENSGGOP00000010144	ENSGGOP00000021887	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.407
ATM	XRCC5	ENSGGOP00000010144	ENSGGOP00000011192	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.943
ATR	ATM	ENSGGOP00000038006	ENSGGOP00000010144	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.995
ATR	XRCC5	ENSGGOP00000038006	ENSGGOP00000011192	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.630
AURKB	ENSGGOP00000051819	ENSGGOP00000002820	ENSGGOP00000051819	Aurora kinase B; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.693
AURKB	NEK2	ENSGGOP00000002820	ENSGGOP00000005327	Aurora kinase B; Belongs to the protein kinase superfamily.	NIMA related kinase 2.	0.714
AURKB	XRCC5	ENSGGOP00000002820	ENSGGOP00000011192	Aurora kinase B; Belongs to the protein kinase superfamily.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.406
CCT2	CCT3	ENSGGOP00000006113	ENSGGOP00000043826	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit gamma.	0.999
CCT2	CCT4	ENSGGOP00000006113	ENSGGOP00000027550	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.999
CCT2	CCT5	ENSGGOP00000006113	ENSGGOP00000027106	Chaperonin containing TCP1 subunit 2.	Chaperonin containing TCP1 subunit 5.	0.999
CCT2	CCT6A	ENSGGOP00000006113	ENSGGOP00000011156	Chaperonin containing TCP1 subunit 2.	Chaperonin containing TCP1 subunit 6A.	0.995
CCT2	CCT7	ENSGGOP00000006113	ENSGGOP00000007603	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.998
CCT2	CCT8	ENSGGOP00000006113	ENSGGOP00000006209	Chaperonin containing TCP1 subunit 2.	Chaperonin containing TCP1 subunit 8.	0.998
CCT2	ENSGGOP00000029415	ENSGGOP00000006113	ENSGGOP00000029415	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.996
CCT2	ENSGGOP00000036793	ENSGGOP00000006113	ENSGGOP00000036793	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.996
CCT2	ENSGGOP00000036928	ENSGGOP00000006113	ENSGGOP00000036928	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.998
CCT2	ENSGGOP00000041124	ENSGGOP00000006113	ENSGGOP00000041124	Chaperonin containing TCP1 subunit 2.	annotation not available	0.995
CCT2	ENSGGOP00000045635	ENSGGOP00000006113	ENSGGOP00000045635	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein; Belongs to the TCP-1 chaperonin family.	0.997