9 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	SSC5D	Uncharacterized protein. (941 aa)
	G3QX51_GORGO	Lipopolysaccharide binding protein. (481 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	ENSGGOP00000021036	annotation not available (839 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000021036	G3QX51_GORGO	ENSGGOP00000021036	ENSGGOP00000007383	annotation not available	Lipopolysaccharide binding protein.	0.609
ENSGGOP00000021036	LY96	ENSGGOP00000021036	ENSGGOP00000015001	annotation not available	Lymphocyte antigen 96.	0.993
ENSGGOP00000021036	NOD2	ENSGGOP00000021036	ENSGGOP00000010525	annotation not available	Nucleotide binding oligomerization domain containing 2.	0.490
ENSGGOP00000021036	SCARB1	ENSGGOP00000021036	ENSGGOP00000046383	annotation not available	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.722
ENSGGOP00000021036	TLR2	ENSGGOP00000021036	ENSGGOP00000003012	annotation not available	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.791
ENSGGOP00000021036	TREM2	ENSGGOP00000021036	ENSGGOP00000014711	annotation not available	Triggering receptor expressed on myeloid cells 2.	0.442
G3QX51_GORGO	ENSGGOP00000021036	ENSGGOP00000007383	ENSGGOP00000021036	Lipopolysaccharide binding protein.	annotation not available	0.609
G3QX51_GORGO	LY96	ENSGGOP00000007383	ENSGGOP00000015001	Lipopolysaccharide binding protein.	Lymphocyte antigen 96.	0.838
G3QX51_GORGO	TLR2	ENSGGOP00000007383	ENSGGOP00000003012	Lipopolysaccharide binding protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.560
G3QX51_GORGO	TLR4	ENSGGOP00000007383	ENSGGOP00000020706	Lipopolysaccharide binding protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.709
LY96	ENSGGOP00000021036	ENSGGOP00000015001	ENSGGOP00000021036	Lymphocyte antigen 96.	annotation not available	0.993
LY96	G3QX51_GORGO	ENSGGOP00000015001	ENSGGOP00000007383	Lymphocyte antigen 96.	Lipopolysaccharide binding protein.	0.838
LY96	NOD2	ENSGGOP00000015001	ENSGGOP00000010525	Lymphocyte antigen 96.	Nucleotide binding oligomerization domain containing 2.	0.428
LY96	TLR2	ENSGGOP00000015001	ENSGGOP00000003012	Lymphocyte antigen 96.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.946
LY96	TLR4	ENSGGOP00000015001	ENSGGOP00000020706	Lymphocyte antigen 96.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.999
NOD2	ENSGGOP00000021036	ENSGGOP00000010525	ENSGGOP00000021036	Nucleotide binding oligomerization domain containing 2.	annotation not available	0.490
NOD2	LY96	ENSGGOP00000010525	ENSGGOP00000015001	Nucleotide binding oligomerization domain containing 2.	Lymphocyte antigen 96.	0.428
NOD2	TLR2	ENSGGOP00000010525	ENSGGOP00000003012	Nucleotide binding oligomerization domain containing 2.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.812
NOD2	TLR4	ENSGGOP00000010525	ENSGGOP00000020706	Nucleotide binding oligomerization domain containing 2.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.589
SCARB1	ENSGGOP00000021036	ENSGGOP00000046383	ENSGGOP00000021036	Scavenger receptor class B member 1; Belongs to the CD36 family.	annotation not available	0.722