STRINGSTRING
ABL1 ABL1 ENSGGOP00000051997 ENSGGOP00000051997 BTN3A1 BTN3A1 SCRIB SCRIB CEBPG CEBPG ENSGGOP00000043190 ENSGGOP00000043190 ENSGGOP00000041335 ENSGGOP00000041335 ENSGGOP00000040205 ENSGGOP00000040205 HRAS HRAS ENSGGOP00000038658 ENSGGOP00000038658 PDE4D PDE4D FZD5 FZD5 RASGRP1 RASGRP1 ENSGGOP00000030478 ENSGGOP00000030478 ARID5A ARID5A SLC7A5 SLC7A5 HAVCR2 HAVCR2 TLR3 TLR3 FAM49B FAM49B IL27 IL27 IRF8 IRF8 IL2 IL2 TLR7 TLR7 FADD FADD SLAMF1 SLAMF1 TNFSF4 TNFSF4 CRTAM CRTAM CCR2 CCR2 PYCARD PYCARD TRIM27 TRIM27 IL18 IL18 G3RH36_GORGO G3RH36_GORGO SASH3 SASH3 G3RG63_GORGO G3RG63_GORGO CD276 CD276 G3RCR2_GORGO G3RCR2_GORGO G3QFY0_GORGO G3QFY0_GORGO SLC11A1 SLC11A1 IL18R1 IL18R1 TLR8 TLR8 G3R8G6_GORGO G3R8G6_GORGO IL27RA IL27RA RIPK2 RIPK2 CD14 CD14 ISL1 ISL1 TXK TXK HSPD1 HSPD1 IL21 IL21 WNT5A WNT5A G3QW36_GORGO G3QW36_GORGO G3QVY2_GORGO G3QVY2_GORGO F2RL1 F2RL1 IL12A IL12A PDE4B PDE4B CD3E CD3E IL23R IL23R IL12RB2 IL12RB2 IL1B IL1B CD226 CD226 TYK2 TYK2 G3QT76_GORGO G3QT76_GORGO G3QT71_GORGO G3QT71_GORGO CD244 CD244 G3QRS4_GORGO G3QRS4_GORGO CD2 CD2 IL12B IL12B G3QN85_GORGO G3QN85_GORGO G3QMP2_GORGO G3QMP2_GORGO IL1R1 IL1R1 LRRC1 LRRC1 IL12RB1 IL12RB1 IL23A IL23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1149 aa)
ENSGGOP00000051997C-type lectin domain containing 7A. (247 aa)
BTN3A1Butyrophilin subfamily 3 member A1. (513 aa)
SCRIBScribble planar cell polarity protein. (1658 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
ENSGGOP00000043190Uncharacterized protein. (234 aa)
ENSGGOP00000041335Uncharacterized protein. (158 aa)
ENSGGOP00000040205Galectin. (355 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSGGOP00000038658ANK_REP_REGION domain-containing protein. (398 aa)
PDE4DPhosphodiesterase. (748 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
RASGRP1RAS guanyl releasing protein 1. (848 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
IL27Interleukin 27. (244 aa)
IRF8Interferon regulatory factor 8. (426 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TRIM27Tripartite motif containing 27. (513 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
G3RH36_GORGOInterferon lambda 1. (200 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
G3RG63_GORGOISG15 ubiquitin like modifier. (165 aa)
CD276CD276 molecule. (534 aa)
G3RCR2_GORGOMajor histocompatibility complex, class II, DP beta 1. (258 aa)
G3QFY0_GORGOMajor histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
G3R8G6_GORGOHistocompatibility minor serpin domain containing; Belongs to the serpin family. (170 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
ISL1ISL LIM homeobox 1. (351 aa)
TXKTyrosine-protein kinase. (527 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
G3QW36_GORGOUncharacterized protein. (652 aa)
G3QVY2_GORGOHistocompatibility minor HB-1. (41 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PDE4BPhosphodiesterase. (736 aa)
CD3ECD3e molecule. (207 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (862 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CD226CD226 molecule. (336 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G3QT71_GORGOLymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
CD244CD244 molecule. (365 aa)
G3QRS4_GORGOZP domain-containing protein. (290 aa)
CD2CD2 molecule. (351 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
G3QN85_GORGOSLAM family member 6. (331 aa)
G3QMP2_GORGOProtein tyrosine phosphatase non-receptor type 22. (693 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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