63 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LILRA5	Leukocyte immunoglobulin like receptor A5. (300 aa)
	G3RGJ6_GORGO	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family. (201 aa)
	G3RI71_GORGO	NACHT domain-containing protein. (1127 aa)
	MEFV	MEFV innate immuity regulator, pyrin. (781 aa)
	HK1	Hexokinase 1. (921 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	G3RQF4_GORGO	Leukocyte immunoglobulin like receptor A2. (483 aa)
	IL6	Interleukin 6. (234 aa)
	ORM1	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family. (201 aa)
	CCL3	C-C motif chemokine. (92 aa)
	MALT1	MALT1 paracaspase. (824 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	IFI16	Interferon gamma inducible protein 16. (785 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MNDA	Myeloid cell nuclear differentiation antigen. (407 aa)
	PANX-2	Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
	G3QRP1_GORGO	Uncharacterized protein. (107 aa)
	NLRP3	NLR family pyrin domain containing 3. (1028 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	CCL19	C-C motif chemokine. (98 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	GBP5	Guanylate binding protein 5. (586 aa)
	G3QF49_GORGO	Azurocidin 1. (251 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	ENSGGOP00000021036	annotation not available (839 aa)
	INAVA	Innate immunity activator. (663 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	G3RD86_GORGO	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	ENSGGOP00000029367	Pyrin domain-containing protein. (110 aa)
	ENSGGOP00000030478	Tyrosine-protein kinase. (1151 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	STMP1	Short transmembrane mitochondrial protein 1. (47 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	ENSGGOP00000040205	Galectin. (355 aa)
	NAIP	Uncharacterized protein. (198 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (342 aa)
	ENSGGOP00000043849	Lipocln_cytosolic_FA-bd_dom domain-containing protein. (196 aa)
	ENSGGOP00000045267	Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
	SMAD3	Mothers against decapentaplegic homolog. (356 aa)
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	APP	Amyloid beta precursor protein. (771 aa)
	ENSGGOP00000050319	Advanced glycosylation end-product specific receptor. (411 aa)
	ENSGGOP00000051997	C-type lectin domain containing 7A. (247 aa)
	CARD8	Caspase recruitment domain family member 8. (522 aa)
	IL17A	Interleukin 17A. (155 aa)
	G3R2E9_GORGO	Uncharacterized protein. (524 aa)
	ISL1	ISL LIM homeobox 1. (351 aa)
	NLRP12	NLR family pyrin domain containing 12. (1065 aa)
	NLRP2	NLR family pyrin domain containing 2. (1040 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	G3QV30_GORGO	Gasdermin D. (532 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	NLRP1	NLR family pyrin domain containing 1. (1471 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (492 aa)
	G3RD62_GORGO	Uncharacterized protein. (488 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CARD8	ENSGGOP00000006002	ENSGGOP00000000255	Absent in melanoma 2.	Caspase recruitment domain family member 8.	0.826
AIM2	ENSGGOP00000029367	ENSGGOP00000006002	ENSGGOP00000029367	Absent in melanoma 2.	Pyrin domain-containing protein.	0.540
AIM2	ENSGGOP00000033404	ENSGGOP00000006002	ENSGGOP00000033404	Absent in melanoma 2.	Caspase 8; Belongs to the peptidase C14A family.	0.472
AIM2	ENSGGOP00000045267	ENSGGOP00000006002	ENSGGOP00000045267	Absent in melanoma 2.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.735
AIM2	ENSGGOP00000046758	ENSGGOP00000006002	ENSGGOP00000046758	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.991
AIM2	G3QT76_GORGO	ENSGGOP00000006002	ENSGGOP00000005887	Absent in melanoma 2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.472
AIM2	G3QV30_GORGO	ENSGGOP00000006002	ENSGGOP00000006593	Absent in melanoma 2.	Gasdermin D.	0.816
AIM2	G3RI71_GORGO	ENSGGOP00000006002	ENSGGOP00000015360	Absent in melanoma 2.	NACHT domain-containing protein.	0.672
AIM2	GBP5	ENSGGOP00000006002	ENSGGOP00000001639	Absent in melanoma 2.	Guanylate binding protein 5.	0.424
AIM2	IFI16	ENSGGOP00000006002	ENSGGOP00000005994	Absent in melanoma 2.	Interferon gamma inducible protein 16.	0.973
AIM2	IL6	ENSGGOP00000006002	ENSGGOP00000018546	Absent in melanoma 2.	Interleukin 6.	0.458
AIM2	MEFV	ENSGGOP00000006002	ENSGGOP00000015416	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.977
AIM2	MYD88	ENSGGOP00000006002	ENSGGOP00000003761	Absent in melanoma 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.463
AIM2	NAIP	ENSGGOP00000006002	ENSGGOP00000042462	Absent in melanoma 2.	Uncharacterized protein.	0.749
AIM2	NLRC4	ENSGGOP00000006002	ENSGGOP00000002707	Absent in melanoma 2.	NLR family CARD domain containing 4.	0.959
AIM2	NLRP1	ENSGGOP00000006002	ENSGGOP00000011186	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.977
AIM2	NLRP12	ENSGGOP00000006002	ENSGGOP00000008682	Absent in melanoma 2.	NLR family pyrin domain containing 12.	0.792
AIM2	NLRP2	ENSGGOP00000006002	ENSGGOP00000007590	Absent in melanoma 2.	NLR family pyrin domain containing 2.	0.778
AIM2	NLRP3	ENSGGOP00000006002	ENSGGOP00000004737	Absent in melanoma 2.	NLR family pyrin domain containing 3.	0.420
AIM2	NOD1	ENSGGOP00000006002	ENSGGOP00000022426	Absent in melanoma 2.	Nucleotide binding oligomerization domain containing 1.	0.458