38 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL17A	Interleukin 17A. (155 aa)
	ENSGGOP00000051997	C-type lectin domain containing 7A. (247 aa)
	ENSGGOP00000050319	Advanced glycosylation end-product specific receptor. (411 aa)
	ENSGGOP00000049072	Protein kinase domain-containing protein. (296 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	ENSGGOP00000040205	Galectin. (355 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	IRF5	Interferon regulatory factor 5. (499 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (403 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	TLR3	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
	SCIMP	SLP adaptor and CSK interacting membrane protein. (144 aa)
	CD40	CD40 molecule. (277 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	MDK	Midkine. (143 aa)
	TIRAP	TIR domain containing adaptor protein. (221 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (262 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	ISL1	ISL LIM homeobox 1. (351 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	G3QT80_GORGO	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (244 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1331 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	CCL19	C-C motif chemokine. (98 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL19	CCR7	ENSGGOP00000002889	ENSGGOP00000015939	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.992
CCR7	CCL19	ENSGGOP00000015939	ENSGGOP00000002889	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.992
CCR7	CD40	ENSGGOP00000015939	ENSGGOP00000024263	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD40 molecule.	0.531
CCR7	CD40LG	ENSGGOP00000015939	ENSGGOP00000037941	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.563
CCR7	G3QT80_GORGO	ENSGGOP00000015939	ENSGGOP00000005891	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.616
CCR7	IDO1	ENSGGOP00000015939	ENSGGOP00000028211	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Indoleamine 2,3-dioxygenase 1.	0.431
CCR7	IFNG	ENSGGOP00000015939	ENSGGOP00000005908	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.679
CCR7	IL17A	ENSGGOP00000015939	ENSGGOP00000009506	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin 17A.	0.521
CD36	CD40LG	ENSGGOP00000005986	ENSGGOP00000037941	CD36 molecule; Belongs to the CD36 family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.464
CD36	ENSGGOP00000050319	ENSGGOP00000005986	ENSGGOP00000050319	CD36 molecule; Belongs to the CD36 family.	Advanced glycosylation end-product specific receptor.	0.578
CD36	ENSGGOP00000051997	ENSGGOP00000005986	ENSGGOP00000051997	CD36 molecule; Belongs to the CD36 family.	C-type lectin domain containing 7A.	0.603
CD36	IFNG	ENSGGOP00000005986	ENSGGOP00000005908	CD36 molecule; Belongs to the CD36 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.446
CD36	LEP	ENSGGOP00000005986	ENSGGOP00000000941	CD36 molecule; Belongs to the CD36 family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.516
CD40	CCR7	ENSGGOP00000024263	ENSGGOP00000015939	CD40 molecule.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.531
CD40	CD40LG	ENSGGOP00000024263	ENSGGOP00000037941	CD40 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.998
CD40	ENSGGOP00000035952	ENSGGOP00000024263	ENSGGOP00000035952	CD40 molecule.	TNF receptor-associated factor.	0.476
CD40	G3QT80_GORGO	ENSGGOP00000024263	ENSGGOP00000005891	CD40 molecule.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.515
CD40	IFNG	ENSGGOP00000024263	ENSGGOP00000005908	CD40 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.680
CD40	TLR3	ENSGGOP00000024263	ENSGGOP00000027247	CD40 molecule.	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.519
CD40	TRAF6	ENSGGOP00000024263	ENSGGOP00000005734	CD40 molecule.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.945