97 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGGOP00000038080	Uncharacterized protein. (54 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	ENSGGOP00000038747	Uncharacterized protein. (1063 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	ENSGGOP00000040205	Galectin. (355 aa)
	IL33	Interleukin 33. (270 aa)
	ENSGGOP00000044526	Uncharacterized protein. (82 aa)
	ENSGGOP00000045092	Uncharacterized protein. (86 aa)
	RAB7B	RAB7B, member RAS oncogene family. (174 aa)
	POU2F2	POU domain protein. (618 aa)
	SELENOK	Selenoprotein K. (93 aa)
	IL6R	Interleukin 6 receptor. (468 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	AKIRIN2	Akirin 2. (203 aa)
	SPON2	Spondin 2. (331 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	IL1RL2	Interleukin 1 receptor like 2. (575 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	EREG	EGF-like domain-containing protein. (222 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	IL17F	Interleukin 17F. (163 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1331 aa)
	G3QRP1_GORGO	Uncharacterized protein. (107 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	G3QUW7_GORGO	TIR domain-containing adapter molecule 1. (563 aa)
	G3QVG0_GORGO	Basigin (Ok blood group). (386 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	HYAL2	Hyaluronidase. (473 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	G3QX51_GORGO	Lipopolysaccharide binding protein. (481 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	NLRP10	NLR family pyrin domain containing 10. (661 aa)
	ISL1	ISL LIM homeobox 1. (351 aa)
	IL17A	Interleukin 17A. (155 aa)
	G3R3U7_GORGO	Mitochondrial antiviral signaling protein. (481 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	UCN	Urocortin. (124 aa)
	G3R7S6_GORGO	CD74 molecule. (296 aa)
	G3R8K9_GORGO	Allograft inflammatory factor 1. (147 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (687 aa)
	G3R905_GORGO	Interleukin 17 receptor C. (787 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
	G3RD62_GORGO	Uncharacterized protein. (488 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	G3RID2_GORGO	TIR domain-containing protein. (1033 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	IL36A	Interleukin-1. (158 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	G3RQF4_GORGO	Leukocyte immunoglobulin like receptor A2. (483 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
	G3RR23_GORGO	Uncharacterized protein. (210 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	G3RRP1_GORGO	Uncharacterized protein. (270 aa)
	IL6	Interleukin 6. (234 aa)
	TIRAP	TIR domain containing adaptor protein. (221 aa)
	G3RT65_GORGO	Sphingosine kinase 2. (663 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	IL17RA	Interleukin 17 receptor A. (865 aa)
	G3S0Q7_GORGO	SET domain containing 4. (440 aa)
	INAVA	Innate immunity activator. (663 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	BTK	Tyrosine-protein kinase. (693 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (741 aa)
	SCIMP	SLP adaptor and CSK interacting membrane protein. (144 aa)
	DHX9	DExH-box helicase 9. (1270 aa)
	TLR3	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
	POU2AF1	POU class 2 homeobox associating factor 1. (256 aa)
	LILRA5	Leukocyte immunoglobulin like receptor A5. (300 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	ARID5A	AT-rich interaction domain 5A. (594 aa)
	ENSGGOP00000033484	Uncharacterized protein. (184 aa)
	ENSGGOP00000034163	Uncharacterized protein. (485 aa)
	ENSGGOP00000035916	Uncharacterized protein. (304 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	ENSGGOP00000036103	Uncharacterized protein. (509 aa)
	ENSGGOP00000037095	Uncharacterized protein. (575 aa)
	TSLP	Thymic stromal lymphopoietin. (159 aa)
	ENSGGOP00000048129	Caspase recruitment domain family member 9. (536 aa)
	APP	Amyloid beta precursor protein. (771 aa)
	ENSGGOP00000050319	Advanced glycosylation end-product specific receptor. (411 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	ENSGGOP00000051997	C-type lectin domain containing 7A. (247 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2B	F2R	ENSGGOP00000001620	ENSGGOP00000010184	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	0.909
APP	BTK	ENSGGOP00000049928	ENSGGOP00000025088	Amyloid beta precursor protein.	Tyrosine-protein kinase.	0.534
APP	CD36	ENSGGOP00000049928	ENSGGOP00000005986	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.619
APP	ENSGGOP00000035916	ENSGGOP00000049928	ENSGGOP00000035916	Amyloid beta precursor protein.	Uncharacterized protein.	0.574
APP	ENSGGOP00000050319	ENSGGOP00000049928	ENSGGOP00000050319	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.734
APP	G3QT76_GORGO	ENSGGOP00000049928	ENSGGOP00000005887	Amyloid beta precursor protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.608
APP	G3R7S6_GORGO	ENSGGOP00000049928	ENSGGOP00000011421	Amyloid beta precursor protein.	CD74 molecule.	0.801
APP	G3R8K9_GORGO	ENSGGOP00000049928	ENSGGOP00000011720	Amyloid beta precursor protein.	Allograft inflammatory factor 1.	0.579
APP	HSPD1	ENSGGOP00000049928	ENSGGOP00000008081	Amyloid beta precursor protein.	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family.	0.699
APP	IL1B	ENSGGOP00000049928	ENSGGOP00000006245	Amyloid beta precursor protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.647
APP	IL6	ENSGGOP00000049928	ENSGGOP00000018546	Amyloid beta precursor protein.	Interleukin 6.	0.511
APP	STAT3	ENSGGOP00000049928	ENSGGOP00000020538	Amyloid beta precursor protein.	Signal transducer and activator of transcription.	0.557
APP	TLR2	ENSGGOP00000049928	ENSGGOP00000003012	Amyloid beta precursor protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.450
BCL10	BTK	ENSGGOP00000051225	ENSGGOP00000025088	CARD domain-containing protein.	Tyrosine-protein kinase.	0.462
BCL10	DDX58	ENSGGOP00000051225	ENSGGOP00000024163	CARD domain-containing protein.	DExD/H-box helicase 58.	0.687
BCL10	ENSGGOP00000035952	ENSGGOP00000051225	ENSGGOP00000035952	CARD domain-containing protein.	TNF receptor-associated factor.	0.645
BCL10	ENSGGOP00000048129	ENSGGOP00000051225	ENSGGOP00000048129	CARD domain-containing protein.	Caspase recruitment domain family member 9.	0.994
BCL10	ENSGGOP00000051997	ENSGGOP00000051225	ENSGGOP00000051997	CARD domain-containing protein.	C-type lectin domain containing 7A.	0.634
BCL10	G3QT76_GORGO	ENSGGOP00000051225	ENSGGOP00000005887	CARD domain-containing protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.519
BCL10	G3R3U7_GORGO	ENSGGOP00000051225	ENSGGOP00000009929	CARD domain-containing protein.	Mitochondrial antiviral signaling protein.	0.526