STRINGSTRING
HDAC2 HDAC2 NRIP1 NRIP1 RBM4B RBM4B ENSGGOP00000048901 ENSGGOP00000048901 MTA1 MTA1 NOCT NOCT ENSGGOP00000046555 ENSGGOP00000046555 RORC RORC NR0B2 NR0B2 NAMPT NAMPT PPARA PPARA HUWE1 HUWE1 HNRNPU HNRNPU PPP1CB PPP1CB ENSGGOP00000036865 ENSGGOP00000036865 ARNTL ARNTL GFPT1 GFPT1 PPP1CC PPP1CC ENSGGOP00000034003 ENSGGOP00000034003 ENSGGOP00000033934 ENSGGOP00000033934 ENSGGOP00000033459 ENSGGOP00000033459 ENSGGOP00000033016 ENSGGOP00000033016 ENSGGOP00000032627 ENSGGOP00000032627 ENSGGOP00000032087 ENSGGOP00000032087 EGR1 EGR1 ARNTL2 ARNTL2 ENSGGOP00000029700 ENSGGOP00000029700 KDM2A KDM2A CIART CIART CRY1 CRY1 LGR4 LGR4 NCOA2 NCOA2 G3S4X5_GORGO G3S4X5_GORGO G3RVX3_GORGO G3RVX3_GORGO RELB RELB MC3R MC3R NUDT12 NUDT12 G3RPM5_GORGO G3RPM5_GORGO HDAC3 HDAC3 ID1 ID1 BHLHE40 BHLHE40 BHLHE41 BHLHE41 OGT OGT ZFHX3 ZFHX3 HDAC1 HDAC1 PRMT5 PRMT5 MYCBP2 MYCBP2 SIRT1 SIRT1 ATF4 ATF4 G3R3C0_GORGO G3R3C0_GORGO PPARGC1A PPARGC1A NR1D1 NR1D1 TOP1 TOP1 SIRT6 SIRT6 NGFR NGFR ID3 ID3 KDM8 KDM8 NPAS2 NPAS2 G3QU62_GORGO G3QU62_GORGO PASD1 PASD1 PER1 PER1 CLOCK CLOCK USP2 USP2 CARTPT CARTPT PER2 PER2 DRD2 DRD2 CRY2 CRY2 G3QE83_GORGO G3QE83_GORGO RORA RORA G3QCX1_GORGO G3QCX1_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
ENSGGOP00000048901Retinoic acid induced 1. (1948 aa)
MTA1Metastasis associated 1. (734 aa)
NOCTEndo/exonuclease/phosphatase domain-containing protein. (383 aa)
ENSGGOP00000046555Caveolae associated protein 3. (293 aa)
RORCRAR related orphan receptor C. (521 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (267 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4400 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
ENSGGOP00000036865RRM domain-containing protein. (155 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (346 aa)
ENSGGOP00000034003Zona pellucida binding protein 2. (388 aa)
ENSGGOP00000033934Uncharacterized protein. (318 aa)
ENSGGOP00000033459BZIP domain-containing protein. (350 aa)
ENSGGOP00000033016Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (419 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
ENSGGOP00000032087BZIP domain-containing protein. (342 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa)
ENSGGOP00000029700Uncharacterized protein. (315 aa)
KDM2AUncharacterized protein. (723 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
CRY1Cryptochrome circadian regulator 1. (623 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (929 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
G3S4X5_GORGOMAGE family member D1. (834 aa)
G3RVX3_GORGOLysine demethylase 5A. (1510 aa)
RELBRELB proto-oncogene, NF-kB subunit. (579 aa)
MC3RMelanocortin 3 receptor. (323 aa)
NUDT12Nudix hydrolase 12. (462 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
BHLHE41Basic helix-loop-helix family member e41. (419 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ZFHX3Zinc finger homeobox 3. (3622 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
MYCBP2MYC binding protein 2. (4640 aa)
SIRT1Sirtuin 1. (751 aa)
ATF4Activating transcription factor 4. (351 aa)
G3R3C0_GORGOSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa)
SIRT6Sirtuin 6. (355 aa)
NGFRNerve growth factor receptor. (427 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
KDM8Lysine demethylase 8. (454 aa)
NPAS2Neuronal PAS domain protein 2. (824 aa)
G3QU62_GORGOMYB binding protein 1a. (1114 aa)
PASD1PAS domain containing repressor 1. (770 aa)
PER1Period circadian regulator 1. (1290 aa)
CLOCKClock circadian regulator. (847 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
CARTPTCART prepropeptide. (116 aa)
PER2Period circadian regulator 2. (1255 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
G3QE83_GORGOPeriod circadian regulator 3. (1074 aa)
RORARAR related orphan receptor A. (555 aa)
G3QCX1_GORGOCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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