STRINGSTRING
ENSGGOP00000051874 ENSGGOP00000051874 CDK5RAP2 CDK5RAP2 PCID2 PCID2 ACTR8 ACTR8 LMNA LMNA NAF1 NAF1 NDC80 NDC80 CTCF CTCF SMARCD3 SMARCD3 CCDC174 CCDC174 CCNB1 CCNB1 BECN1 BECN1 G3QGV2_GORGO G3QGV2_GORGO ESPL1 ESPL1 FBXO5 FBXO5 G3QH59_GORGO G3QH59_GORGO G3QIJ6_GORGO G3QIJ6_GORGO BUB1B BUB1B CENPF CENPF MAD2L1 MAD2L1 UPF1 UPF1 AURKB AURKB CTC1 CTC1 DLGAP5 DLGAP5 TPR TPR ZWILCH ZWILCH SMC6 SMC6 AXIN2 AXIN2 UCHL5 UCHL5 TERF2 TERF2 PRAP1 PRAP1 G3QQG6_GORGO G3QQG6_GORGO G3QR56_GORGO G3QR56_GORGO RMI2 RMI2 USP7 USP7 NEK2 NEK2 FBXO4 FBXO4 TRAPPC12 TRAPPC12 CCT2 CCT2 CCT8 CCT8 NSMCE1 NSMCE1 G3QVR1_GORGO G3QVR1_GORGO DUSP1 DUSP1 ZWINT ZWINT CUL3 CUL3 HASPIN HASPIN GNL3L GNL3L CDCA8 CDCA8 CCT7 CCT7 MAPK15 MAPK15 NUF2 NUF2 NSMCE2 NSMCE2 G3QZ33_GORGO G3QZ33_GORGO PINX1 PINX1 SPC24 SPC24 ANAPC5 ANAPC5 TTK TTK USP44 USP44 SIRT6 SIRT6 G3R0N2_GORGO G3R0N2_GORGO MNAT1 MNAT1 RUVBL2 RUVBL2 NCAPD2 NCAPD2 G3R2C0_GORGO G3R2C0_GORGO SSBP1 SSBP1 NAA10 NAA10 TNKS2 TNKS2 MCPH1 MCPH1 PSMG2 PSMG2 G3R3L1_GORGO G3R3L1_GORGO PNKP PNKP ATM ATM CDC20 CDC20 G3R4Q3_GORGO G3R4Q3_GORGO G3R534_GORGO G3R534_GORGO SMG5 SMG5 PPP1R10 PPP1R10 TASOR TASOR G3R6V6_GORGO G3R6V6_GORGO CCT6A CCT6A GNL3 GNL3 XRCC5 XRCC5 HDAC8 HDAC8 ANAPC2 ANAPC2 TNKS TNKS G3R7T7_GORGO G3R7T7_GORGO SMARCE1 SMARCE1 RAD21 RAD21 INO80E INO80E FEN1 FEN1 SLX1 SLX1 G3RBT3_GORGO G3RBT3_GORGO HECW2 HECW2 TRIM28 TRIM28 IK IK PRKCQ PRKCQ SMC4 SMC4 ARID2 ARID2 TCP1 TCP1 YLPM1 YLPM1 ERCC4 ERCC4 G3REM6_GORGO G3REM6_GORGO FSHR FSHR FBXO42 FBXO42 INO80B INO80B ENSGGOP00000051974 ENSGGOP00000051974 G3RF97_GORGO G3RF97_GORGO G3RF99_GORGO G3RF99_GORGO POT1 POT1 CDC27 CDC27 G3RFN1_GORGO G3RFN1_GORGO MCM2 MCM2 PKIB PKIB PHF10 PHF10 NFRKB NFRKB CDC16 CDC16 CDC6 CDC6 INO80D INO80D ACTL6A ACTL6A KLHL22 KLHL22 DYNC1LI1 DYNC1LI1 PBRM1 PBRM1 SETDB2 SETDB2 SETDB1 SETDB1 G3RJZ9_GORGO G3RJZ9_GORGO G3RK43_GORGO G3RK43_GORGO G3RK47_GORGO G3RK47_GORGO BAZ1B BAZ1B DNMT1 DNMT1 SLX4 SLX4 SMC5 SMC5 SMARCC1 SMARCC1 PTTG1 PTTG1 HNRNPA2B1 HNRNPA2B1 BCL7C BCL7C SMARCD2 SMARCD2 DKC1 DKC1 SHCBP1L SHCBP1L G3RPG7_GORGO G3RPG7_GORGO G3RPM5_GORGO G3RPM5_GORGO G3RPS1_GORGO G3RPS1_GORGO MAD2L1BP MAD2L1BP SLF2 SLF2 SRC SRC APC APC RTEL1 RTEL1 MYC MYC G3RT90_GORGO G3RT90_GORGO BCL7B BCL7B ZW10 ZW10 KAT2B KAT2B PARN PARN SMG6 SMG6 G3RXR2_GORGO G3RXR2_GORGO MAP3K4 MAP3K4 RIOK2 RIOK2 MRE11 MRE11 G3RZ66_GORGO G3RZ66_GORGO INO80C INO80C SFPQ SFPQ SMARCC2 SMARCC2 MAPK3 MAPK3 CHFR CHFR LIG4 LIG4 CENPVL2 CENPVL2 CENPVL1 CENPVL1 TOP2A TOP2A WAPL WAPL KAT5 KAT5 UBE2C UBE2C G3S758_GORGO G3S758_GORGO BUB3 BUB3 YY1 YY1 PIF1 PIF1 DCP2 DCP2 G3SA94_GORGO G3SA94_GORGO RESF1 RESF1 G3SB22_GORGO G3SB22_GORGO DPF3 DPF3 G3SB61_GORGO G3SB61_GORGO PARP1 PARP1 NBN NBN SPC25 SPC25 KNTC1 KNTC1 TERF2IP TERF2IP SMARCA5 SMARCA5 BRD7 BRD7 CDC23 CDC23 FEN1-2 FEN1-2 CCT5 CCT5 G3SH76_GORGO G3SH76_GORGO CCT4 CCT4 TERF1 TERF1 G3SI52_GORGO G3SI52_GORGO LCMT1 LCMT1 CDT1 CDT1 MOS MOS G3SKL0_GORGO G3SKL0_GORGO DHX36 DHX36 G3SKQ6_GORGO G3SKQ6_GORGO ENSGGOP00000029025 ENSGGOP00000029025 ENSGGOP00000029158 ENSGGOP00000029158 ANAPC15 ANAPC15 ENSGGOP00000029415 ENSGGOP00000029415 ENSGGOP00000030111 ENSGGOP00000030111 ENSGGOP00000030281 ENSGGOP00000030281 ENSGGOP00000052195 ENSGGOP00000052195 ENSGGOP00000030646 ENSGGOP00000030646 ENSGGOP00000030777 ENSGGOP00000030777 SMARCA2 SMARCA2 EXOSC10 EXOSC10 DDX11 DDX11 ENSGGOP00000032315 ENSGGOP00000032315 ENSGGOP00000032867 ENSGGOP00000032867 TENT4B TENT4B DPF2 DPF2 TAL1 TAL1 NCAPG NCAPG ENSGGOP00000034103 ENSGGOP00000034103 NAT10 NAT10 ARID1A ARID1A ENSGGOP00000034799 ENSGGOP00000034799 SMARCA4 SMARCA4 ENSGGOP00000035282 ENSGGOP00000035282 SMARCD1 SMARCD1 ENSGGOP00000035506 ENSGGOP00000035506 SIN3A SIN3A ENSGGOP00000035777 ENSGGOP00000035777 XRN1 XRN1 ENSGGOP00000036118 ENSGGOP00000036118 SPDL1 SPDL1 ENSGGOP00000036645 ENSGGOP00000036645 ENSGGOP00000036793 ENSGGOP00000036793 ERCC1 ERCC1 ENSGGOP00000036928 ENSGGOP00000036928 ENSGGOP00000037457 ENSGGOP00000037457 STN1 STN1 ATR ATR SENP6 SENP6 PTTG2 PTTG2 MORC2 MORC2 HNRNPU HNRNPU TINF2 TINF2 ATF7IP ATF7IP ENSGGOP00000039935 ENSGGOP00000039935 ENSGGOP00000039936 ENSGGOP00000039936 MAPK1 MAPK1 ATRX ATRX ENSGGOP00000041124 ENSGGOP00000041124 ENSGGOP00000041237 ENSGGOP00000041237 MAP2K7 MAP2K7 BAZ1A BAZ1A SLF1 SLF1 ENSGGOP00000042199 ENSGGOP00000042199 INCENP INCENP MCRS1 MCRS1 ENSGGOP00000042920 ENSGGOP00000042920 ENSGGOP00000043030 ENSGGOP00000043030 ENSGGOP00000043187 ENSGGOP00000043187 GEN1 GEN1 CENPVL3 CENPVL3 CCT3 CCT3 MAD1L1 MAD1L1 RNF4 RNF4 ENSGGOP00000045302 ENSGGOP00000045302 ENSGGOP00000045424 ENSGGOP00000045424 ENSGGOP00000045635 ENSGGOP00000045635 ENSGGOP00000045734 ENSGGOP00000045734 NCAPH NCAPH SMC2 SMC2 ENSGGOP00000046516 ENSGGOP00000046516 MAPKAPK5 MAPKAPK5 BUB1 BUB1 ZNF207 ZNF207 CDC26 CDC26 NUMA1 NUMA1 ENSGGOP00000047885 ENSGGOP00000047885 ENSGGOP00000047900 ENSGGOP00000047900 ENSGGOP00000048162 ENSGGOP00000048162 NEK7 NEK7 ATF7IP2 ATF7IP2 ENSGGOP00000048713 ENSGGOP00000048713 CTNNB1 CTNNB1 ENSGGOP00000049238 ENSGGOP00000049238 ENSGGOP00000049876 ENSGGOP00000049876 NABP2 NABP2 CENPE CENPE ENSGGOP00000050973 ENSGGOP00000050973 DPF1 DPF1 ENSGGOP00000051819 ENSGGOP00000051819
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSGGOP00000051874Uncharacterized protein. (66 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1893 aa)
PCID2PCI domain-containing protein. (255 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
NAF1Nuclear assembly factor 1 ribonucleoprotein. (494 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
CTCFCCCTC-binding factor. (727 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa)
CCDC174Coiled-coil domain containing 174. (467 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
BECN1Beclin 1. (450 aa)
G3QGV2_GORGOZinc finger protein 304. (706 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
FBXO5F-box protein 5. (447 aa)
G3QH59_GORGOCore histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
G3QIJ6_GORGOBAF chromatin remodeling complex subunit BCL7A. (203 aa)
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa)
CENPFCentromere protein F. (3057 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
UPF1UPF1 RNA helicase and ATPase. (1054 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
DLGAP5DLG associated protein 5. (846 aa)
TPRTranslocated promoter region, nuclear basket protein. (2363 aa)
ZWILCHZwilch kinetochore protein. (571 aa)
SMC6Structural maintenance of chromosomes 6. (1064 aa)
AXIN2Axin 2. (843 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (368 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
PRAP1Uncharacterized protein. (150 aa)
G3QQG6_GORGOSET domain and mariner transposase fusion gene. (684 aa)
G3QR56_GORGODNA repair protein XRCC4. (336 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa)
NEK2NIMA related kinase 2. (445 aa)
FBXO4F-box protein 4. (387 aa)
TRAPPC12Trafficking protein particle complex 12. (739 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
CCT8Chaperonin containing TCP1 subunit 8. (548 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
G3QVR1_GORGOSMG1_N domain-containing protein. (562 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ZWINTZW10 interacting kinetochore protein. (279 aa)
CUL3Cullin 3; Belongs to the cullin family. (767 aa)
HASPINHistone H3 associated protein kinase. (798 aa)
GNL3LG protein nucleolar 3 like. (585 aa)
CDCA8Cell division cycle associated 8. (280 aa)
CCT7T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (464 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa)
G3QZ33_GORGOUncharacterized protein; Belongs to the AAA ATPase family. (362 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (331 aa)
SPC24Uncharacterized protein. (209 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
TTKTTK protein kinase. (856 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (712 aa)
SIRT6Sirtuin 6. (355 aa)
G3R0N2_GORGOUncharacterized protein. (849 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1401 aa)
G3R2C0_GORGODNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (294 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
NAA10N(alpha)-acetyltransferase 10, NatA catalytic subunit. (235 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
MCPH1Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). (785 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
G3R3L1_GORGOUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2642 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (519 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
CDC20Cell division cycle 20. (499 aa)
G3R4Q3_GORGORuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (447 aa)
G3R534_GORGONon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (328 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (939 aa)
TASORTranscription activation suppressor. (1610 aa)
G3R6V6_GORGOTestis expressed 14, intercellular bridge forming factor. (1466 aa)
CCT6AChaperonin containing TCP1 subunit 6A. (531 aa)
GNL3G protein nucleolar 3. (549 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
G3R7T7_GORGOAT-rich interaction domain 1B. (2015 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
RAD21RAD21 cohesin complex component. (631 aa)
INO80EINO80 complex subunit E. (244 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (354 aa)
G3RBT3_GORGOUncharacterized protein. (1516 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)
TRIM28Tripartite motif containing 28. (701 aa)
IKIK cytokine. (557 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
ARID2AT-rich interaction domain 2. (1834 aa)
TCP1T-complex 1. (556 aa)
YLPM1YLP motif containing 1. (2111 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
G3REM6_GORGOAnaphase promoting complex subunit 7. (496 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
FBXO42F-box protein 42. (717 aa)
INO80BPAPA-1 domain-containing protein. (556 aa)
ENSGGOP00000051974HMG box domain-containing protein. (359 aa)
G3RF97_GORGOUncharacterized protein. (827 aa)
G3RF99_GORGOWW domain binding protein 1. (303 aa)
POT1Protection of telomeres 1. (634 aa)
CDC27Cell division cycle 27. (705 aa)
G3RFN1_GORGOUncharacterized protein. (344 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
PKIBcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (85 aa)
PHF10PHD finger protein 10. (469 aa)
NFRKBNuclear factor related to kappaB binding protein. (1324 aa)
CDC16Cell division cycle 16. (620 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
INO80DINO80 complex subunit D. (1027 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
KLHL22Kelch like family member 22. (634 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (497 aa)
PBRM1Polybromo 1. (1665 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (719 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
G3RJZ9_GORGORB transcriptional corepressor 1. (756 aa)
G3RK43_GORGOActin like 6B; Belongs to the actin family. (358 aa)
G3RK47_GORGOTCF3 fusion partner. (253 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1539 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1658 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1834 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1054 aa)
PTTG1Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (242 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
SHCBP1LSHC binding and spindle associated 1 like. (653 aa)
G3RPG7_GORGOPeriphilin 1. (458 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
G3RPS1_GORGOWD_REPEATS_REGION domain-containing protein. (457 aa)
MAD2L1BPMAD2L1 binding protein. (306 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1173 aa)
SRCTyrosine-protein kinase. (542 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1301 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
G3RT90_GORGOHORMA domain-containing protein. (143 aa)
BCL7BUncharacterized protein. (272 aa)
ZW10Zw10 kinetochore protein. (779 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (820 aa)
PARNPoly(A)-specific ribonuclease. (621 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
G3RXR2_GORGOHMG box domain-containing protein. (369 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1608 aa)
RIOK2RIO kinase 2. (552 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
G3RZ66_GORGORRM domain-containing protein. (252 aa)
INO80CINO80 complex subunit C. (228 aa)
SFPQSplicing factor proline and glutamine rich. (590 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CHFRCheckpoint with forkhead and ring finger domains. (643 aa)
LIG4DNA ligase. (911 aa)
CENPVL2Centromere protein V like 2. (282 aa)
CENPVL1Centromere protein V like 1. (272 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
WAPLWAPL cohesin release factor. (1190 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
G3S758_GORGOUncharacterized protein. (172 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
YY1YY1 transcription factor. (414 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
DCP2Decapping mRNA 2. (420 aa)
G3SA94_GORGOCell division cycle associated 5. (262 aa)
RESF1Retroelement silencing factor 1. (1747 aa)
G3SB22_GORGOHeterogeneous nuclear ribonucleoprotein D. (293 aa)
DPF3Double PHD fingers 3. (412 aa)
G3SB61_GORGOTelomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa)
SPC25SPC25 component of NDC80 kinetochore complex. (224 aa)
KNTC1Kinetochore associated 1. (2209 aa)
TERF2IPTERF2 interacting protein. (399 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
BRD7Bromodomain containing 7. (652 aa)
CDC23Cell division cycle 23. (597 aa)
FEN1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa)
CCT5Chaperonin containing TCP1 subunit 5. (541 aa)
G3SH76_GORGOAnaphase promoting complex subunit 4. (708 aa)
CCT4T-complex protein 1 subunit delta. (501 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
G3SI52_GORGOUncharacterized protein. (435 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (340 aa)
CDT1Chromatin licensing and DNA replication factor 1. (552 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
G3SKL0_GORGOSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (377 aa)
DHX36DEAH-box helicase 36. (1008 aa)
G3SKQ6_GORGOUncharacterized protein. (563 aa)
ENSGGOP00000029025Uncharacterized protein. (420 aa)
ENSGGOP00000029158Uncharacterized protein. (42 aa)
ANAPC15Anaphase promoting complex subunit 15. (190 aa)
ENSGGOP00000029415Uncharacterized protein. (76 aa)
ENSGGOP00000030111Protein kinase domain-containing protein. (210 aa)
ENSGGOP00000030281Uncharacterized protein. (331 aa)
ENSGGOP00000052195Uncharacterized protein. (108 aa)
ENSGGOP00000030646Uncharacterized protein. (111 aa)
ENSGGOP00000030777Transforming acidic coiled-coil containing protein 3. (832 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1510 aa)
EXOSC10Exosome component 10. (888 aa)
DDX11DEAD/H-box helicase 11. (951 aa)
ENSGGOP00000032315Uncharacterized protein. (111 aa)
ENSGGOP00000032867Uncharacterized protein. (96 aa)
TENT4BTerminal nucleotidyltransferase 4B. (691 aa)
DPF2Double PHD fingers 2. (405 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
NCAPGNon-SMC condensin I complex subunit G. (1055 aa)
ENSGGOP00000034103Uncharacterized protein. (106 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa)
ARID1AAT-rich interaction domain 1A. (2258 aa)
ENSGGOP00000034799ACD shelterin complex subunit and telomerase recruitment factor. (475 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1689 aa)
ENSGGOP00000035282Bromo domain-containing protein. (601 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (477 aa)
ENSGGOP00000035506Uncharacterized protein. (91 aa)
SIN3AUncharacterized protein. (154 aa)
ENSGGOP00000035777Baculoviral IAP repeat containing 5. (165 aa)
XRN15'-3' exoribonuclease 1. (1707 aa)
ENSGGOP00000036118Uncharacterized protein. (128 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (605 aa)
ENSGGOP00000036645Uncharacterized protein. (182 aa)
ENSGGOP00000036793Uncharacterized protein. (453 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ENSGGOP00000036928Uncharacterized protein. (504 aa)
ENSGGOP00000037457NIMA related kinase 6. (373 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
SENP6SUMO specific peptidase 6. (1112 aa)
PTTG2Pituitary tumor-transforming 2. (196 aa)
MORC2MORC family CW-type zinc finger 2. (1032 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
ATF7IPActivating transcription factor 7 interacting protein. (1278 aa)
ENSGGOP00000039935Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
ENSGGOP00000039936Anaphase promoting complex subunit 11. (196 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATRXATRX chromatin remodeler. (2492 aa)
ENSGGOP00000041124annotation not available (563 aa)
ENSGGOP00000041237Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (377 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
BAZ1APHD-type domain-containing protein. (593 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1058 aa)
ENSGGOP00000042199Uncharacterized protein. (539 aa)
INCENPInner centromere protein. (903 aa)
MCRS1Microspherule protein 1. (475 aa)
ENSGGOP00000042920Mitotic arrest deficient 2 like 2. (241 aa)
ENSGGOP00000043030Serine/threonine-protein kinase PLK. (624 aa)
ENSGGOP00000043187annotation not available (111 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
CENPVL3Centromere protein V like 3. (287 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (699 aa)
RNF4Ring finger protein 4. (190 aa)
ENSGGOP00000045302ATF7IP_BD domain-containing protein. (371 aa)
ENSGGOP00000045424UBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa)
ENSGGOP00000045635Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (161 aa)
ENSGGOP00000045734Uncharacterized protein. (127 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
SMC2Structural maintenance of chromosomes protein. (1197 aa)
ENSGGOP00000046516Uncharacterized protein; Belongs to the peptidase C19 family. (410 aa)
MAPKAPK5MAPK activated protein kinase 5. (490 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa)
ZNF207Zinc finger protein 207. (497 aa)
CDC26Cell division cycle 26. (85 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2115 aa)
ENSGGOP00000047885Uncharacterized protein. (76 aa)
ENSGGOP00000047900Uncharacterized protein. (453 aa)
ENSGGOP00000048162HMG box domain-containing protein. (352 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
ATF7IP2Activating transcription factor 7 interacting protein 2. (681 aa)
ENSGGOP00000048713Uncharacterized protein. (227 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSGGOP00000049238Uncharacterized protein. (383 aa)
ENSGGOP00000049876annotation not available (227 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2701 aa)
ENSGGOP00000050973Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
DPF1Double PHD fingers 1. (398 aa)
ENSGGOP00000051819Protein kinase domain-containing protein. (421 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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