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| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | G3R0N2_GORGO | Uncharacterized protein. (849 aa) |
| | ENSGGOP00000052195 | Uncharacterized protein. (108 aa) |
| | ENSGGOP00000051974 | HMG box domain-containing protein. (359 aa) |
| | ENSGGOP00000051874 | Uncharacterized protein. (66 aa) |
| | ENSGGOP00000051819 | Protein kinase domain-containing protein. (421 aa) |
| | DPF1 | Double PHD fingers 1. (398 aa) |
| | ENSGGOP00000050973 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2701 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | ENSGGOP00000049876 | annotation not available (227 aa) |
| | ENSGGOP00000049238 | Uncharacterized protein. (383 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | ENSGGOP00000048713 | Uncharacterized protein. (227 aa) |
| | ATF7IP2 | Activating transcription factor 7 interacting protein 2. (681 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa) |
| | ENSGGOP00000048162 | HMG box domain-containing protein. (352 aa) |
| | ENSGGOP00000047900 | Uncharacterized protein. (453 aa) |
| | ENSGGOP00000047885 | Uncharacterized protein. (76 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2115 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | ZNF207 | Zinc finger protein 207. (497 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (490 aa) |
| | ENSGGOP00000046516 | Uncharacterized protein; Belongs to the peptidase C19 family. (410 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1197 aa) |
| | NCAPH | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa) |
| | ENSGGOP00000045734 | Uncharacterized protein. (127 aa) |
| | ENSGGOP00000045635 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (161 aa) |
| | ENSGGOP00000045424 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa) |
| | ENSGGOP00000045302 | ATF7IP_BD domain-containing protein. (371 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (699 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (545 aa) |
| | CENPVL3 | Centromere protein V like 3. (287 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | ENSGGOP00000043187 | annotation not available (111 aa) |
| | ENSGGOP00000043030 | Serine/threonine-protein kinase PLK. (624 aa) |
| | ENSGGOP00000042920 | Mitotic arrest deficient 2 like 2. (241 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | INCENP | Inner centromere protein. (903 aa) |
| | ENSGGOP00000042199 | Uncharacterized protein. (539 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | BAZ1A | PHD-type domain-containing protein. (593 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | ENSGGOP00000041237 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (377 aa) |
| | ENSGGOP00000041124 | annotation not available (563 aa) |
| | ATRX | ATRX chromatin remodeler. (2492 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ENSGGOP00000039936 | Anaphase promoting complex subunit 11. (196 aa) |
| | ENSGGOP00000039935 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa) |
| | ATF7IP | Activating transcription factor 7 interacting protein. (1278 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (451 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (825 aa) |
| | MORC2 | MORC family CW-type zinc finger 2. (1032 aa) |
| | PTTG2 | Pituitary tumor-transforming 2. (196 aa) |
| | SENP6 | SUMO specific peptidase 6. (1112 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | ENSGGOP00000037457 | NIMA related kinase 6. (373 aa) |
| | ENSGGOP00000036928 | Uncharacterized protein. (504 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | ENSGGOP00000036793 | Uncharacterized protein. (453 aa) |
| | ENSGGOP00000036645 | Uncharacterized protein. (182 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (605 aa) |
| | ENSGGOP00000036118 | Uncharacterized protein. (128 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1707 aa) |
| | ENSGGOP00000035777 | Baculoviral IAP repeat containing 5. (165 aa) |
| | SIN3A | Uncharacterized protein. (154 aa) |
| | ENSGGOP00000035506 | Uncharacterized protein. (91 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (477 aa) |
| | ENSGGOP00000035282 | Bromo domain-containing protein. (601 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1689 aa) |
| | ENSGGOP00000034799 | ACD shelterin complex subunit and telomerase recruitment factor. (475 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2258 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa) |
| | ENSGGOP00000034103 | Uncharacterized protein. (106 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1055 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa) |
| | DPF2 | Double PHD fingers 2. (405 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (691 aa) |
| | ENSGGOP00000032867 | Uncharacterized protein. (96 aa) |
| | ENSGGOP00000032315 | Uncharacterized protein. (111 aa) |
| | DDX11 | DEAD/H-box helicase 11. (951 aa) |
| | EXOSC10 | Exosome component 10. (888 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1510 aa) |
| | ENSGGOP00000030777 | Transforming acidic coiled-coil containing protein 3. (832 aa) |
| | ENSGGOP00000030646 | Uncharacterized protein. (111 aa) |
| | ENSGGOP00000030281 | Uncharacterized protein. (331 aa) |
| | ENSGGOP00000030111 | Protein kinase domain-containing protein. (210 aa) |
| | ENSGGOP00000029415 | Uncharacterized protein. (76 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (190 aa) |
| | ENSGGOP00000029158 | Uncharacterized protein. (42 aa) |
| | ENSGGOP00000029025 | Uncharacterized protein. (420 aa) |
| | G3SKQ6_GORGO | Uncharacterized protein. (563 aa) |
| | DHX36 | DEAH-box helicase 36. (1008 aa) |
| | G3SKL0_GORGO | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (377 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (552 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (340 aa) |
| | G3SI52_GORGO | Uncharacterized protein. (435 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (501 aa) |
| | G3SH76_GORGO | Anaphase promoting complex subunit 4. (708 aa) |
| | CCT5 | Chaperonin containing TCP1 subunit 5. (541 aa) |
| | FEN1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | TERF2IP | TERF2 interacting protein. (399 aa) |
| | KNTC1 | Kinetochore associated 1. (2209 aa) |
| | SPC25 | SPC25 component of NDC80 kinetochore complex. (224 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | G3SB61_GORGO | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa) |
| | DPF3 | Double PHD fingers 3. (412 aa) |
| | G3SB22_GORGO | Heterogeneous nuclear ribonucleoprotein D. (293 aa) |
| | RESF1 | Retroelement silencing factor 1. (1747 aa) |
| | G3SA94_GORGO | Cell division cycle associated 5. (262 aa) |
| | DCP2 | Decapping mRNA 2. (420 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | YY1 | YY1 transcription factor. (414 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | G3S758_GORGO | Uncharacterized protein. (172 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | WAPL | WAPL cohesin release factor. (1190 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa) |
| | CENPVL1 | Centromere protein V like 1. (272 aa) |
| | CENPVL2 | Centromere protein V like 2. (282 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | CHFR | Checkpoint with forkhead and ring finger domains. (643 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (590 aa) |
| | INO80C | INO80 complex subunit C. (228 aa) |
| | G3RZ66_GORGO | RRM domain-containing protein. (252 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | RIOK2 | RIO kinase 2. (552 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1608 aa) |
| | G3RXR2_GORGO | HMG box domain-containing protein. (369 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) |
| | PARN | Poly(A)-specific ribonuclease. (621 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (820 aa) |
| | ZW10 | Zw10 kinetochore protein. (779 aa) |
| | BCL7B | Uncharacterized protein. (272 aa) |
| | G3RT90_GORGO | HORMA domain-containing protein. (143 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1301 aa) |
| | APC | APC regulator of WNT signaling pathway. (2844 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1173 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (306 aa) |
| | G3RPS1_GORGO | WD_REPEATS_REGION domain-containing protein. (457 aa) |
| | G3RPM5_GORGO | Promyelocytic leukemia. (834 aa) |
| | G3RPG7_GORGO | Periphilin 1. (458 aa) |
| | SHCBP1L | SHC binding and spindle associated 1 like. (653 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (242 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa) |
| | PTTG1 | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1054 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1834 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1658 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1539 aa) |
| | G3RK47_GORGO | TCF3 fusion partner. (253 aa) |
| | G3RK43_GORGO | Actin like 6B; Belongs to the actin family. (358 aa) |
| | G3RJZ9_GORGO | RB transcriptional corepressor 1. (756 aa) |
| | CDK5RAP2 | CDK5 regulatory subunit associated protein 2. (1893 aa) |
| | PCID2 | PCI domain-containing protein. (255 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (664 aa) |
| | NAF1 | Nuclear assembly factor 1 ribonucleoprotein. (494 aa) |
| | NDC80 | NDC80 kinetochore complex component. (642 aa) |
| | CTCF | CCCTC-binding factor. (727 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa) |
| | CCDC174 | Coiled-coil domain containing 174. (467 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (433 aa) |
| | BECN1 | Beclin 1. (450 aa) |
| | G3QGV2_GORGO | Zinc finger protein 304. (706 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2120 aa) |
| | FBXO5 | F-box protein 5. (447 aa) |
| | G3QH59_GORGO | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | G3QIJ6_GORGO | BAF chromatin remodeling complex subunit BCL7A. (203 aa) |
| | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa) |
| | CENPF | Centromere protein F. (3057 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1054 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | DLGAP5 | DLG associated protein 5. (846 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2363 aa) |
| | ZWILCH | Zwilch kinetochore protein. (571 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1064 aa) |
| | AXIN2 | Axin 2. (843 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (368 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | PRAP1 | Uncharacterized protein. (150 aa) |
| | G3QQG6_GORGO | SET domain and mariner transposase fusion gene. (684 aa) |
| | G3QR56_GORGO | DNA repair protein XRCC4. (336 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa) |
| | NEK2 | NIMA related kinase 2. (445 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (739 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (535 aa) |
| | CCT8 | Chaperonin containing TCP1 subunit 8. (548 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | G3QVR1_GORGO | SMG1_N domain-containing protein. (562 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | ZWINT | ZW10 interacting kinetochore protein. (279 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (767 aa) |
| | HASPIN | Histone H3 associated protein kinase. (798 aa) |
| | GNL3L | G protein nucleolar 3 like. (585 aa) |
| | CDCA8 | Cell division cycle associated 8. (280 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (464 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa) |
| | G3QZ33_GORGO | Uncharacterized protein; Belongs to the AAA ATPase family. (362 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (331 aa) |
| | SPC24 | Uncharacterized protein. (209 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | TTK | TTK protein kinase. (856 aa) |
| | USP44 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (712 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | SETDB1 | SET domain bifurcated histone lysine methyltransferase 1. (1292 aa) |
| | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2. (719 aa) |
| | PBRM1 | Polybromo 1. (1665 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (497 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1324 aa) |
| | PHF10 | PHD finger protein 10. (469 aa) |
| | PKIB | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (85 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | G3RFN1_GORGO | Uncharacterized protein. (344 aa) |
| | CDC27 | Cell division cycle 27. (705 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | G3RF99_GORGO | WW domain binding protein 1. (303 aa) |
| | G3RF97_GORGO | Uncharacterized protein. (827 aa) |
| | INO80B | PAPA-1 domain-containing protein. (556 aa) |
| | FBXO42 | F-box protein 42. (717 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | G3REM6_GORGO | Anaphase promoting complex subunit 7. (496 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | YLPM1 | YLP motif containing 1. (2111 aa) |
| | TCP1 | T-complex 1. (556 aa) |
| | ARID2 | AT-rich interaction domain 2. (1834 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa) |
| | IK | IK cytokine. (557 aa) |
| | TRIM28 | Tripartite motif containing 28. (701 aa) |
| | HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa) |
| | G3RBT3_GORGO | Uncharacterized protein. (1516 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (354 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | G3R7T7_GORGO | AT-rich interaction domain 1B. (2015 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | HDAC8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | GNL3 | G protein nucleolar 3. (549 aa) |
| | CCT6A | Chaperonin containing TCP1 subunit 6A. (531 aa) |
| | G3R6V6_GORGO | Testis expressed 14, intercellular bridge forming factor. (1466 aa) |
| | TASOR | Transcription activation suppressor. (1610 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (939 aa) |
| | SMG5 | SMG5 nonsense mediated mRNA decay factor. (1016 aa) |
| | G3R534_GORGO | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (328 aa) |
| | G3R4Q3_GORGO | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (447 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (519 aa) |
| | G3R3L1_GORGO | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2642 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa) |
| | MCPH1 | Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). (785 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | NAA10 | N(alpha)-acetyltransferase 10, NatA catalytic subunit. (235 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | G3R2C0_GORGO | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (294 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1401 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
