STRINGSTRING
RNF167 RNF167 MIOS MIOS KPTN KPTN FLCN FLCN BECN1 BECN1 EIF2S1 EIF2S1 UCP2 UCP2 LARS1 LARS1 GCN1 GCN1 SESN3 SESN3 MAP1LC3A MAP1LC3A NPRL2 NPRL2 ATF4 ATF4 ITFG2 ITFG2 MTOR MTOR SEH1L SEH1L G3R786_GORGO G3R786_GORGO EIF2AK3 EIF2AK3 PRKD1 PRKD1 SZT2 SZT2 G3RDD1_GORGO G3RDD1_GORGO ATF3 ATF3 SESN2 SESN2 WDR59 WDR59 C12H12orf66 C12H12orf66 CDKN1A CDKN1A RRAGD RRAGD EIF2AK2 EIF2AK2 G3RXC5_GORGO G3RXC5_GORGO MAPK3 MAPK3 BMT2 BMT2 MAP3K5 MAP3K5 RRAGA RRAGA EIF2AK4 EIF2AK4 FAS FAS DAPL1 DAPL1 ATF2 ATF2 ENSGGOP00000032087 ENSGGOP00000032087 ENSGGOP00000033459 ENSGGOP00000033459 ENSGGOP00000033934 ENSGGOP00000033934 ENSGGOP00000036167 ENSGGOP00000036167 IMPACT IMPACT SESN1 SESN1 MAPK1 MAPK1 RRAGC RRAGC MAPK8 MAPK8 NPRL3 NPRL3 DAP DAP MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF167Ring finger protein 167. (351 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
KPTNKaptin, actin binding protein. (436 aa)
FLCNFolliculin. (579 aa)
BECN1Beclin 1. (450 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa)
GCN1GCN1 activator of EIF2AK4. (2671 aa)
SESN3Sestrin 3. (492 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
ATF4Activating transcription factor 4. (351 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
G3R786_GORGORas related GTP binding B. (374 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
G3RDD1_GORGOWD repeat domain 24. (920 aa)
ATF3Activating transcription factor 3. (181 aa)
SESN2Sestrin 2. (480 aa)
WDR59WD repeat domain 59. (974 aa)
C12H12orf66Chromosome 12 open reading frame 66. (468 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RRAGDRas related GTP binding D. (400 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
G3RXC5_GORGOTranscription factor EB. (551 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
RRAGARas related GTP binding A. (313 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
FASFas cell surface death receptor. (340 aa)
DAPL1Uncharacterized protein. (134 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000032087BZIP domain-containing protein. (342 aa)
ENSGGOP00000033459BZIP domain-containing protein. (350 aa)
ENSGGOP00000033934Uncharacterized protein. (318 aa)
ENSGGOP00000036167SH3 domain containing GRB2 like, endophilin B1. (402 aa)
IMPACTUPF0029 domain-containing protein. (226 aa)
SESN1Sestrin 1. (551 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RRAGCRas related GTP binding C. (399 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
DAPDeath associated protein. (185 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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