STRINGSTRING
PRDX5 PRDX5 ENSGGOP00000051951 ENSGGOP00000051951 MAPK10 MAPK10 ENSGGOP00000050768 ENSGGOP00000050768 ENSGGOP00000050644 ENSGGOP00000050644 HDAC6 HDAC6 MAPK8 MAPK8 ENSGGOP00000048540 ENSGGOP00000048540 MPO MPO ROMO1 ROMO1 ENSGGOP00000046735 ENSGGOP00000046735 FXN FXN MMP2 MMP2 ENSGGOP00000046276 ENSGGOP00000046276 ENSGGOP00000046010 ENSGGOP00000046010 ENSGGOP00000045096 ENSGGOP00000045096 ENSGGOP00000044113 ENSGGOP00000044113 SMPD3 SMPD3 SOD1 SOD1 ENSGGOP00000042764 ENSGGOP00000042764 ENSGGOP00000041746 ENSGGOP00000041746 EGFR EGFR MAPK1 MAPK1 ENSGGOP00000039304 ENSGGOP00000039304 NCF1 NCF1 ENSGGOP00000038997 ENSGGOP00000038997 ENSGGOP00000037657 ENSGGOP00000037657 ANKZF1 ANKZF1 IMPACT IMPACT ENSGGOP00000035220 ENSGGOP00000035220 ENSGGOP00000034320 ENSGGOP00000034320 NFE2L2 NFE2L2 RHOB RHOB PRDX1 PRDX1 ENSGGOP00000029762 ENSGGOP00000029762 ENSGGOP00000029619 ENSGGOP00000029619 PRDX3 PRDX3 RELA RELA CAMKK2 CAMKK2 MPV17 MPV17 FANCC FANCC BTK BTK EZH2 EZH2 OSER1 OSER1 PTPRK PTPRK MAPK9 MAPK9 NET1 NET1 ECT2 ECT2 MAP3K5 MAP3K5 APOA4 APOA4 ATP7A ATP7A MAPK3 MAPK3 TRPA1 TRPA1 PRDX2 PRDX2 ZNF580 ZNF580 PRKAA1 PRKAA1 SIRPA SIRPA TPM1 TPM1 G3RVC8_GORGO G3RVC8_GORGO IL6 IL6 G3RRQ8_GORGO G3RRQ8_GORGO ARG1 ARG1 G3RRK1_GORGO G3RRK1_GORGO SRC SRC UCP1 UCP1 SETX SETX G3RNX2_GORGO G3RNX2_GORGO G3RNT3_GORGO G3RNT3_GORGO CRYGD CRYGD IL18BP IL18BP AGAP3 AGAP3 SPHK1 SPHK1 NOS3 NOS3 PDK2 PDK2 KDM6B KDM6B BNIP3 BNIP3 AMBP AMBP G3RCP0_GORGO G3RCP0_GORGO MMP9 MMP9 CDK1 CDK1 EDN1 EDN1 GLRX2 GLRX2 RIPK1 RIPK1 G3R8T5_GORGO G3R8T5_GORGO PJVK PJVK CAT CAT ABL1 ABL1 SIRT1 SIRT1 FER FER AQP1 AQP1 CCS CCS FABP1 FABP1 PPARGC1B PPARGC1B CHUK CHUK PDCD10 PDCD10 SOD2 SOD2 FYN FYN PCGF2 PCGF2 G3QXD0_GORGO G3QXD0_GORGO NME8 NME8 ERN1 ERN1 RPS3 RPS3 MAP1LC3A MAP1LC3A TREX1 TREX1 MAPK7 MAPK7 MT3 MT3 G3QS47_GORGO G3QS47_GORGO HDAC2 HDAC2 PLEKHA1 PLEKHA1 RIPK3 RIPK3 ANXA1 ANXA1 STK25 STK25 MAPK13 MAPK13 ADPRHL2 ADPRHL2 TNFAIP3 TNFAIP3 PKD2 PKD2 NQO1 NQO1 PRKCD PRKCD G3QKE2_GORGO G3QKE2_GORGO SIGMAR1 SIGMAR1 ERCC6L2 ERCC6L2 PDGFD PDGFD PCNA PCNA BECN1 BECN1 STAT6 STAT6 RNF112 RNF112 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
ENSGGOP00000051951KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
ENSGGOP00000050768Paired box 2. (392 aa)
ENSGGOP00000050644Ribosomal_S3_C domain-containing protein. (100 aa)
HDAC6Histone deacetylase 6. (1218 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000048540Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
MPOMyeloperoxidase. (747 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
FXNFrataxin. (210 aa)
MMP2Matrix metallopeptidase 2. (610 aa)
ENSGGOP00000046276Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (172 aa)
ENSGGOP00000046010Protein kinase domain-containing protein. (372 aa)
ENSGGOP00000045096KH type-2 domain-containing protein. (245 aa)
ENSGGOP00000044113Uncharacterized protein. (1081 aa)
SMPD3Uncharacterized protein. (535 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ENSGGOP00000042764Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
ENSGGOP00000041746Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSGGOP00000039304KH type-2 domain-containing protein. (116 aa)
NCF1Uncharacterized protein. (367 aa)
ENSGGOP00000038997Uncharacterized protein. (178 aa)
ENSGGOP00000037657Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ANKZF1ANK_REP_REGION domain-containing protein. (732 aa)
IMPACTUPF0029 domain-containing protein. (226 aa)
ENSGGOP00000035220Thioredoxin domain-containing protein. (136 aa)
ENSGGOP00000034320Transient receptor potential cation channel subfamily M member 2. (1553 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
RHOBRas homolog family member B. (196 aa)
PRDX1Peroxiredoxin 1. (220 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
ENSGGOP00000029619Thioredoxin domain-containing protein. (188 aa)
PRDX3Peroxiredoxin 3. (256 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
BTKTyrosine-protein kinase. (693 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
OSER1Oxidative stress responsive serine rich 1. (318 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1455 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NET1Neuroepithelial cell transforming 1. (599 aa)
ECT2Epithelial cell transforming 2. (914 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
APOA4Apolipoprotein A4. (396 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
PRDX2Peroxiredoxin 2. (198 aa)
ZNF580Zinc finger protein 580. (172 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SIRPASignal regulatory protein alpha. (508 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
G3RVC8_GORGOUncharacterized protein; Belongs to the beta/gamma-crystallin family. (144 aa)
IL6Interleukin 6. (234 aa)
G3RRQ8_GORGOAXL receptor tyrosine kinase. (843 aa)
ARG1Arginase. (322 aa)
G3RRK1_GORGOUncharacterized protein. (497 aa)
SRCTyrosine-protein kinase. (542 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
SETXSenataxin. (2649 aa)
G3RNX2_GORGOProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
G3RNT3_GORGOKH type-2 domain-containing protein. (250 aa)
CRYGDCrystallin gamma D; Belongs to the beta/gamma-crystallin family. (174 aa)
IL18BPInterleukin 18 binding protein. (189 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (879 aa)
SPHK1Sphingosine kinase 1. (472 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
KDM6BLysine demethylase 6B. (1687 aa)
BNIP3Uncharacterized protein. (194 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (352 aa)
G3RCP0_GORGOHSF_DOMAIN domain-containing protein. (527 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
EDN1Endothelin 1. (212 aa)
GLRX2Glutaredoxin 2. (174 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
PJVKPejvakin. (352 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SIRT1Sirtuin 1. (751 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
FABP1Fatty acid binding protein 1. (127 aa)
PPARGC1BPPARG coactivator 1 beta. (997 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PDCD10Programmed cell death 10. (212 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (234 aa)
FYNTyrosine-protein kinase. (537 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
G3QXD0_GORGOApoptosis inducing factor mitochondria associated 1. (586 aa)
NME8NME/NM23 family member 8. (588 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MT3Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
G3QS47_GORGOZinc finger protein 277. (383 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
ANXA1Annexin. (346 aa)
STK25Protein kinase domain-containing protein. (426 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
G3QKE2_GORGOAldo-keto reductase family 1 member C3. (323 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
ERCC6L2ERCC excision repair 6 like 2. (712 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BECN1Beclin 1. (450 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
RNF112Ring finger protein 112. (631 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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