(55 nodes) Somatic stem cell population maintenance network (Gorilla gorilla)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	G3QCT9_GORGO	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1590 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (759 aa)
	MED28	Mediator complex subunit 28. (178 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (493 aa)
	G3QHX9_GORGO	Uncharacterized protein. (462 aa)
	LDB1	LIM domain binding 1. (411 aa)
	REST	RE1 silencing transcription factor. (1081 aa)
	MED7	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	YAP1	Uncharacterized protein. (326 aa)
	GATA2	GATA binding protein 2. (480 aa)
	SPI1	Spi-1 proto-oncogene. (271 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (193 aa)
	BCL9L	BCL9 like. (1499 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	SIX2	SIX homeobox 2. (291 aa)
	MED30	Mediator complex subunit 30. (178 aa)
	BCL9	BCL9 transcription coactivator. (1426 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	G3R4L4_GORGO	SKI proto-oncogene. (700 aa)
	SOX4	Transcription factor SOX. (444 aa)
	WNT7A	Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (345 aa)
	NKAP	NFKB activating protein. (416 aa)
	KLF10	Kruppel like factor 10. (479 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	G3RQI9_GORGO	WW domain-containing protein. (413 aa)
	MED14	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1418 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	SALL4	Spalt like transcription factor 4. (1053 aa)
	MED15	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (783 aa)
	LIG4	DNA ligase. (911 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
	G3SIC3_GORGO	Uncharacterized protein. (337 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	KLF4	Kruppel like factor 4. (479 aa)
	CDX2	Caudal type homeobox 2. (313 aa)
	MED12	Mediator complex subunit 12. (2177 aa)
	ENSGGOP00000030855	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (119 aa)
	ENSGGOP00000035259	Structural maintenance of chromosomes 1A. (1096 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
	ENSGGOP00000037735	Uncharacterized protein. (471 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (488 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
	MED21	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (159 aa)
	MED27	Mediator complex subunit 27. (311 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	ENSGGOP00000050356	Replication timing regulatory factor 1. (2281 aa)
	VPS72	Vacuolar protein sorting 72 homolog. (364 aa)
	LDB2	LIM domain binding 2. (373 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	HES1	ENSGGOP00000007261	ENSGGOP00000008330	Achaete-scute family bHLH transcription factor 2.	Hes family bHLH transcription factor 1.	0.456
ASCL2	LDB1	ENSGGOP00000007261	ENSGGOP00000002119	Achaete-scute family bHLH transcription factor 2.	LIM domain binding 1.	0.443
ASCL2	LDB2	ENSGGOP00000007261	ENSGGOP00000052278	Achaete-scute family bHLH transcription factor 2.	LIM domain binding 2.	0.443
BCL9	BCL9L	ENSGGOP00000009087	ENSGGOP00000007961	BCL9 transcription coactivator.	BCL9 like.	0.589
BCL9L	BCL9	ENSGGOP00000007961	ENSGGOP00000009087	BCL9 like.	BCL9 transcription coactivator.	0.589
BMPR1A	NODAL	ENSGGOP00000003658	ENSGGOP00000002542	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.427
BRAF	RAF1	ENSGGOP00000025331	ENSGGOP00000027142	B-Raf proto-oncogene, serine/threonine kinase.	Raf-1 proto-oncogene, serine/threonine kinase.	0.998
BRAF	STAT3	ENSGGOP00000025331	ENSGGOP00000020538	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.644
CDX2	FGF4	ENSGGOP00000028307	ENSGGOP00000009843	Caudal type homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.454
CDX2	KLF4	ENSGGOP00000028307	ENSGGOP00000028127	Caudal type homeobox 2.	Kruppel like factor 4.	0.457
CDX2	SALL4	ENSGGOP00000028307	ENSGGOP00000021231	Caudal type homeobox 2.	Spalt like transcription factor 4.	0.445
CUL4A	LIG4	ENSGGOP00000000409	ENSGGOP00000022303	Cullin 4A; Belongs to the cullin family.	DNA ligase.	0.446
ENSGGOP00000030855	MED12	ENSGGOP00000030855	ENSGGOP00000029544	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 12.	0.983
ENSGGOP00000030855	MED14	ENSGGOP00000030855	ENSGGOP00000019414	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.990
ENSGGOP00000030855	MED15	ENSGGOP00000030855	ENSGGOP00000021420	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.978
ENSGGOP00000030855	MED21	ENSGGOP00000030855	ENSGGOP00000046791	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.549
ENSGGOP00000030855	MED27	ENSGGOP00000030855	ENSGGOP00000047101	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 27.	0.983
ENSGGOP00000030855	MED28	ENSGGOP00000030855	ENSGGOP00000001097	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 28.	0.981
ENSGGOP00000030855	MED30	ENSGGOP00000030855	ENSGGOP00000008950	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 30.	0.982
ENSGGOP00000030855	MED6	ENSGGOP00000030855	ENSGGOP00000043178	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.990