(25 nodes) Embryonic hemopoiesis network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	IL3	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
	SH2B3	SH2B adaptor protein 3. (567 aa)
	TPO	Thyroid peroxidase. (933 aa)
	STK3	Serine/threonine kinase 3. (519 aa)
	ENSGGOP00000041335	Uncharacterized protein. (158 aa)
	THOC5	THO complex 5. (683 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
	ENSGGOP00000033934	Uncharacterized protein. (318 aa)
	ENSGGOP00000033459	BZIP domain-containing protein. (350 aa)
	ENSGGOP00000032087	BZIP domain-containing protein. (342 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	CCDC134	Coiled-coil domain containing 134. (229 aa)
	G3S6F8_GORGO	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1514 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	GATA1	GATA binding protein 1. (413 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	ETNPPL	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
	PBX1	PBX homeobox 1. (430 aa)
	FLT3LG	Fms related tyrosine kinase 3 ligand. (235 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	GATA3	GATA binding protein 3. (444 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	ENSGGOP00000032087	ENSGGOP00000009869	ENSGGOP00000032087	Activating transcription factor 4.	BZIP domain-containing protein.	0.543
ATF4	ENSGGOP00000033459	ENSGGOP00000009869	ENSGGOP00000033459	Activating transcription factor 4.	BZIP domain-containing protein.	0.545
ATF4	ENSGGOP00000033934	ENSGGOP00000009869	ENSGGOP00000033934	Activating transcription factor 4.	Uncharacterized protein.	0.545
ENSGGOP00000032087	ATF4	ENSGGOP00000032087	ENSGGOP00000009869	BZIP domain-containing protein.	Activating transcription factor 4.	0.543
ENSGGOP00000032087	ENSGGOP00000033459	ENSGGOP00000032087	ENSGGOP00000033459	BZIP domain-containing protein.	BZIP domain-containing protein.	0.544
ENSGGOP00000032087	ENSGGOP00000033934	ENSGGOP00000032087	ENSGGOP00000033934	BZIP domain-containing protein.	Uncharacterized protein.	0.546
ENSGGOP00000033459	ATF4	ENSGGOP00000033459	ENSGGOP00000009869	BZIP domain-containing protein.	Activating transcription factor 4.	0.545
ENSGGOP00000033459	ENSGGOP00000032087	ENSGGOP00000033459	ENSGGOP00000032087	BZIP domain-containing protein.	BZIP domain-containing protein.	0.544
ENSGGOP00000033459	ENSGGOP00000033934	ENSGGOP00000033459	ENSGGOP00000033934	BZIP domain-containing protein.	Uncharacterized protein.	0.547
ENSGGOP00000033934	ATF4	ENSGGOP00000033934	ENSGGOP00000009869	Uncharacterized protein.	Activating transcription factor 4.	0.545
ENSGGOP00000033934	ENSGGOP00000032087	ENSGGOP00000033934	ENSGGOP00000032087	Uncharacterized protein.	BZIP domain-containing protein.	0.546
ENSGGOP00000033934	ENSGGOP00000033459	ENSGGOP00000033934	ENSGGOP00000033459	Uncharacterized protein.	BZIP domain-containing protein.	0.547
ENSGGOP00000041335	GATA1	ENSGGOP00000041335	ENSGGOP00000018626	Uncharacterized protein.	GATA binding protein 1.	0.863
ENSGGOP00000041335	GATA3	ENSGGOP00000041335	ENSGGOP00000006027	Uncharacterized protein.	GATA binding protein 3.	0.664
FLT3LG	G3S6F8_GORGO	ENSGGOP00000009899	ENSGGOP00000023665	Fms related tyrosine kinase 3 ligand.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.727
FLT3LG	IL3	ENSGGOP00000009899	ENSGGOP00000001031	Fms related tyrosine kinase 3 ligand.	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.	0.781
FLT3LG	KDR	ENSGGOP00000009899	ENSGGOP00000012526	Fms related tyrosine kinase 3 ligand.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.778
FLT3LG	KIT	ENSGGOP00000009899	ENSGGOP00000015071	Fms related tyrosine kinase 3 ligand.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.902
FLT3LG	KITLG	ENSGGOP00000009899	ENSGGOP00000023005	Fms related tyrosine kinase 3 ligand.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.809
G3S6F8_GORGO	FLT3LG	ENSGGOP00000023665	ENSGGOP00000009899	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Fms related tyrosine kinase 3 ligand.	0.727