(25 nodes) Megakaryocyte development network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3RRP1_GORGO	Uncharacterized protein. (270 aa)
	ZNF385A	Zinc finger protein 385A. (465 aa)
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	FLI1	Fli-1 proto-oncogene, ETS transcription factor. (452 aa)
	ENSGGOP00000041335	Uncharacterized protein. (158 aa)
	ENSGGOP00000037095	Uncharacterized protein. (575 aa)
	ENSGGOP00000036103	Uncharacterized protein. (509 aa)
	MEIS1	Homeobox domain-containing protein. (463 aa)
	ENSGGOP00000034163	Uncharacterized protein. (485 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (396 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	GP1BB	Glycoprotein Ib platelet subunit beta. (206 aa)
	GP1BA	Glycoprotein Ib platelet subunit alpha. (654 aa)
	G3S6F8_GORGO	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1514 aa)
	G3S176_GORGO	MADS-box domain-containing protein. (473 aa)
	WASF2	WASP family member 2. (498 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	GP9	Glycoprotein IX platelet. (177 aa)
	G3R7N7_GORGO	Abl interactor 1. (508 aa)
	EP300	E1A binding protein p300. (2416 aa)
	G3QS37_GORGO	Megakaryocyte and platelet inhibitory receptor G6b. (242 aa)
	FLNA	Filamin A. (2647 aa)
	SH2B3	SH2B adaptor protein 3. (567 aa)
	THPO	Thrombopoietin. (353 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000034163	G3QS37_GORGO	ENSGGOP00000034163	ENSGGOP00000005461	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.809
ENSGGOP00000034163	KIT	ENSGGOP00000034163	ENSGGOP00000015071	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.754
ENSGGOP00000034163	PTPN6	ENSGGOP00000034163	ENSGGOP00000013813	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.527
ENSGGOP00000036103	G3QS37_GORGO	ENSGGOP00000036103	ENSGGOP00000005461	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.689
ENSGGOP00000036103	KIT	ENSGGOP00000036103	ENSGGOP00000015071	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.704
ENSGGOP00000036103	PTPN6	ENSGGOP00000036103	ENSGGOP00000013813	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.484
ENSGGOP00000037095	G3QS37_GORGO	ENSGGOP00000037095	ENSGGOP00000005461	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.689
ENSGGOP00000037095	KIT	ENSGGOP00000037095	ENSGGOP00000015071	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.704
ENSGGOP00000037095	PTPN6	ENSGGOP00000037095	ENSGGOP00000013813	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.478
ENSGGOP00000041335	EP300	ENSGGOP00000041335	ENSGGOP00000008032	Uncharacterized protein.	E1A binding protein p300.	0.474
EP300	ENSGGOP00000041335	ENSGGOP00000008032	ENSGGOP00000041335	E1A binding protein p300.	Uncharacterized protein.	0.474
EP300	G3S6F8_GORGO	ENSGGOP00000008032	ENSGGOP00000023665	E1A binding protein p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.895
EP300	MEIS1	ENSGGOP00000008032	ENSGGOP00000034765	E1A binding protein p300.	Homeobox domain-containing protein.	0.555
FLNA	GP1BA	ENSGGOP00000004136	ENSGGOP00000025405	Filamin A.	Glycoprotein Ib platelet subunit alpha.	0.989
FLNA	GP1BB	ENSGGOP00000004136	ENSGGOP00000026787	Filamin A.	Glycoprotein Ib platelet subunit beta.	0.668
FLNA	GP9	ENSGGOP00000004136	ENSGGOP00000012588	Filamin A.	Glycoprotein IX platelet.	0.526
G3QS37_GORGO	ENSGGOP00000034163	ENSGGOP00000005461	ENSGGOP00000034163	Megakaryocyte and platelet inhibitory receptor G6b.	Uncharacterized protein.	0.809
G3QS37_GORGO	ENSGGOP00000036103	ENSGGOP00000005461	ENSGGOP00000036103	Megakaryocyte and platelet inhibitory receptor G6b.	Uncharacterized protein.	0.689
G3QS37_GORGO	ENSGGOP00000037095	ENSGGOP00000005461	ENSGGOP00000037095	Megakaryocyte and platelet inhibitory receptor G6b.	Uncharacterized protein.	0.689
G3QS37_GORGO	G3RRP1_GORGO	ENSGGOP00000005461	ENSGGOP00000018465	Megakaryocyte and platelet inhibitory receptor G6b.	Uncharacterized protein.	0.689