STRINGSTRING
SUCNR1 SUCNR1 ENSGGOP00000051931 ENSGGOP00000051931 CD93 CD93 ENSGGOP00000050319 ENSGGOP00000050319 APP APP ENSGGOP00000042710 ENSGGOP00000042710 ENSGGOP00000041818 ENSGGOP00000041818 IL33 IL33 TMEM106A TMEM106A C5AR1 C5AR1 ENSGGOP00000030478 ENSGGOP00000030478 CX3CR1 CX3CR1 PLCG2 PLCG2 HAVCR2 HAVCR2 STK39 STK39 SNCA SNCA TLR3 TLR3 FER1L5 FER1L5 PLA2G10 PLA2G10 ENSGGOP00000021036 ENSGGOP00000021036 TLR4 TLR4 PLA2G3 PLA2G3 EDN2 EDN2 CLU CLU WNK4 WNK4 GRN GRN TYROBP TYROBP TREM2 TREM2 G3REL7_GORGO G3REL7_GORGO NMI NMI SLC11A1 SLC11A1 G3R8K9_GORGO G3R8K9_GORGO PRKCE PRKCE SBNO2 SBNO2 G3R4E1_GORGO G3R4E1_GORGO SYK SYK G3R3G6_GORGO G3R3G6_GORGO TRPV1 TRPV1 IFI35 IFI35 IFNGR1 IFNGR1 ADGRF5 ADGRF5 G3QX51_GORGO G3QX51_GORGO DYSF DYSF G3QUW7_GORGO G3QUW7_GORGO TREX1 TREX1 IFNG IFNG G3QT76_GORGO G3QT76_GORGO IL4 IL4 ITGAM ITGAM G3QLM8_GORGO G3QLM8_GORGO L3HYPDH L3HYPDH CSF2 CSF2 G3QF49_GORGO G3QF49_GORGO HAMP HAMP CX3CL1 CX3CL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ENSGGOP00000051931Interferon gamma receptor 2. (356 aa)
CD93CD93 molecule. (652 aa)
ENSGGOP00000050319Advanced glycosylation end-product specific receptor. (411 aa)
APPAmyloid beta precursor protein. (771 aa)
ENSGGOP00000042710Integrin beta. (813 aa)
ENSGGOP00000041818Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (446 aa)
IL33Interleukin 33. (270 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
STK39Serine/threonine kinase 39. (546 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
FER1L5Fer-1 like family member 5. (2093 aa)
PLA2G10Phospholipase A(2). (155 aa)
ENSGGOP00000021036annotation not available (839 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
PLA2G3Phospholipase A2 group III. (539 aa)
EDN2Endothelin 2. (178 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
WNK4WNK lysine deficient protein kinase 4. (1243 aa)
GRNGranulin precursor. (593 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
G3REL7_GORGOJumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
NMIN-myc and STAT interactor. (307 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
G3R8K9_GORGOAllograft inflammatory factor 1. (147 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
SBNO2Strawberry notch homolog 2. (1319 aa)
G3R4E1_GORGOForkhead box P1. (693 aa)
SYKTyrosine-protein kinase. (635 aa)
G3R3G6_GORGOComplement C1q A chain. (245 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
IFI35Interferon induced protein 35. (286 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
DYSFDysferlin. (2119 aa)
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
G3QLM8_GORGOCREB regulated transcription coactivator 3. (596 aa)
L3HYPDHTrans-L-3-hydroxyproline dehydratase. (354 aa)
CSF2Colony stimulating factor 2. (144 aa)
G3QF49_GORGOAzurocidin 1. (251 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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