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MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) | ||||
TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (774 aa) | ||||
TFAP4 | Transcription factor AP-4. (338 aa) | ||||
CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) | ||||
FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) | ||||
BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1972 aa) | ||||
C10H10orf90 | Chromosome 10 open reading frame 90. (691 aa) | ||||
CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) | ||||
E2F1 | E2F transcription factor 1. (437 aa) | ||||
G3QMN8_GORGO | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (236 aa) | ||||
HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) | ||||
RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) | ||||
PRAP1 | Uncharacterized protein. (150 aa) | ||||
CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) | ||||
USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1077 aa) | ||||
NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (464 aa) | ||||
G3QSG6_GORGO | Mitogen-activated protein kinase kinase kinase 20. (780 aa) | ||||
CLOCK | Clock circadian regulator. (847 aa) | ||||
ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) | ||||
ATAD5 | ATPase family AAA domain containing 5. (1844 aa) | ||||
CLSPN | Claspin. (1335 aa) | ||||
G3QTD2_GORGO | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa) | ||||
GRB2 | Growth factor receptor bound protein 2. (217 aa) | ||||
EME2 | Essential meiotic structure-specific endonuclease subunit 2. (375 aa) | ||||
TREX1 | Three prime repair exonuclease 1. (369 aa) | ||||
DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1537 aa) | ||||
CDC5L | Cell division cycle 5 like. (805 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1493 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) | ||||
TAOK1 | TAO kinase 1. (1001 aa) | ||||
HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) | ||||
BLM | BLM RecQ like helicase. (1415 aa) | ||||
RBM38 | Uncharacterized protein. (158 aa) | ||||
GIGYF2 | GRB10 interacting GYF protein 2. (1318 aa) | ||||
G3QYE9_GORGO | Histone H2A; Belongs to the histone H2A family. (143 aa) | ||||
TICRR | TOPBP1 interacting checkpoint and replication regulator. (1911 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) | ||||
CDC14B | Cell division cycle 14B. (461 aa) | ||||
PPM1D | Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa) | ||||
MUC1 | Mucin 1, cell surface associated. (484 aa) | ||||
FBXO31 | F-box protein 31. (543 aa) | ||||
FBXO44 | F-box protein 6. (293 aa) | ||||
SDE2 | SDE2 telomere maintenance homolog. (451 aa) | ||||
G3R3B3_GORGO | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) | ||||
XPC | XPC complex subunit, DNA damage recognition and repair factor. (940 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa) | ||||
BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1149 aa) | ||||
GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) | ||||
WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) | ||||
BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) | ||||
TAOK2 | TAO kinase 2. (1235 aa) | ||||
INTS7 | Integrator complex subunit 7. (962 aa) | ||||
DONSON | Downstream neighbor of SON. (566 aa) | ||||
E2F7 | E2F transcription factor 7. (911 aa) | ||||
PLK2 | Serine/threonine-protein kinase PLK. (685 aa) | ||||
USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa) | ||||
TAOK3 | TAO kinase 3. (898 aa) | ||||
CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) | ||||
SESN2 | Sestrin 2. (480 aa) | ||||
MRNIP | MRN complex interacting protein. (343 aa) | ||||
NDRG1 | N-myc downstream regulated 1. (394 aa) | ||||
RPA2 | Replication protein A2. (270 aa) | ||||
ING4 | Inhibitor of growth protein. (248 aa) | ||||
G3RJV6_GORGO | Tripartite motif containing 39. (518 aa) | ||||
G3RKP6_GORGO | Fork-head domain-containing protein. (467 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) | ||||
RPL26 | Ribosomal protein L26. (145 aa) | ||||
CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) | ||||
G3RPM5_GORGO | Promyelocytic leukemia. (834 aa) | ||||
TRIAP1 | TP53 regulated inhibitor of apoptosis 1. (76 aa) | ||||
MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) | ||||
G3RRP1_GORGO | Uncharacterized protein. (270 aa) | ||||
CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) | ||||
RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) | ||||
PLK3 | Serine/threonine-protein kinase PLK. (673 aa) | ||||
G3RX40_GORGO | BR serine/threonine kinase 1. (787 aa) | ||||
MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) | ||||
G3RZZ0_GORGO | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa) | ||||
CRADD | CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) | ||||
BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa) | ||||
EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa) | ||||
PAXIP1 | PAX interacting protein 1. (981 aa) | ||||
FOXM1 | Forkhead box M1. (763 aa) | ||||
G3SBE5_GORGO | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (459 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa) | ||||
HINFP | Histone H4 transcription factor. (517 aa) | ||||
MIF | Macrophage migration inhibitory factor. (115 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3416 aa) | ||||
RPS27L | 40S ribosomal protein S27. (96 aa) | ||||
PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) | ||||
RINT1 | RAD50 interactor 1. (792 aa) | ||||
ENSGGOP00000028787 | MPN domain-containing protein. (307 aa) | ||||
ENSGGOP00000028825 | BRCT domain-containing protein. (83 aa) | ||||
ENSGGOP00000028878 | Forkhead box O4. (505 aa) | ||||
ENSGGOP00000029067 | KOW domain-containing protein. (138 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (681 aa) | ||||
PIDD1 | P53-induced death domain protein 1. (910 aa) | ||||
ENSGGOP00000029568 | IZUMO family member 4. (247 aa) | ||||
FOXN3 | Forkhead box N3. (490 aa) | ||||
ENSGGOP00000030111 | Protein kinase domain-containing protein. (210 aa) | ||||
PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (472 aa) | ||||
RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) | ||||
ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) | ||||
TIPRL | TOR signaling pathway regulator. (272 aa) | ||||
CCND1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa) | ||||
BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (317 aa) | ||||
ENSGGOP00000033701 | Uncharacterized protein. (503 aa) | ||||
ENSGGOP00000033890 | NIMA related kinase 11. (645 aa) | ||||
CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (531 aa) | ||||
ENSGGOP00000034163 | Uncharacterized protein. (485 aa) | ||||
ENSGGOP00000034312 | FA complementation group D2. (1390 aa) | ||||
ENSGGOP00000034749 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) | ||||
MYO6 | Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa) | ||||
ENSGGOP00000035693 | Pre-mRNA processing factor 19. (524 aa) | ||||
ENSGGOP00000035698 | Uncharacterized protein. (301 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (570 aa) | ||||
ENSGGOP00000036103 | Uncharacterized protein. (509 aa) | ||||
ENSGGOP00000036252 | Uncharacterized protein. (56 aa) | ||||
ENSGGOP00000036466 | Checkpoint kinase 2. (529 aa) | ||||
ENSGGOP00000036560 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (284 aa) | ||||
ENSGGOP00000037095 | Uncharacterized protein. (575 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
ENSGGOP00000038576 | Centrosomal protein 63. (703 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) | ||||
ENSGGOP00000038658 | ANK_REP_REGION domain-containing protein. (398 aa) | ||||
SYF2 | SYF2 pre-mRNA splicing factor. (243 aa) | ||||
ENSGGOP00000040711 | ATR interacting protein. (799 aa) | ||||
ATRX | ATRX chromatin remodeler. (2492 aa) | ||||
ZNF830 | Zinc finger protein 830. (372 aa) | ||||
SP100-2 | SP100 nuclear antigen. (885 aa) | ||||
ENSGGOP00000042920 | Mitotic arrest deficient 2 like 2. (241 aa) | ||||
ENSGGOP00000042938 | Checkpoint protein; Belongs to the HUS1 family. (273 aa) | ||||
ENSGGOP00000043030 | Serine/threonine-protein kinase PLK. (624 aa) | ||||
DGKZ | Diacylglycerol kinase. (1117 aa) | ||||
ENSGGOP00000044043 | Uncharacterized protein. (100 aa) | ||||
ENSGGOP00000045437 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (575 aa) | ||||
ENSGGOP00000045449 | USP domain-containing protein; Belongs to the peptidase C19 family. (290 aa) | ||||
ENSGGOP00000046562 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (261 aa) | ||||
ENSGGOP00000048172 | Uncharacterized protein. (482 aa) | ||||
ENSGGOP00000049072 | Protein kinase domain-containing protein. (296 aa) | ||||
CDKN1B | Uncharacterized protein. (205 aa) | ||||
STK33 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa) | ||||
WAC | WW domain containing adaptor with coiled-coil. (666 aa) | ||||
ENSGGOP00000050973 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) | ||||
DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) | ||||
UIMC1 | Ubiquitin interaction motif containing 1. (720 aa) |