STRINGSTRING
MDM4 MDM4 TIPIN TIPIN RFWD3 RFWD3 TFAP4 TFAP4 CASP9 CASP9 FZR1 FZR1 BATF BATF TP53BP1 TP53BP1 C10H10orf90 C10H10orf90 CASP2 CASP2 E2F1 E2F1 G3QMN8_GORGO G3QMN8_GORGO HIPK2 HIPK2 RAD1 RAD1 PRAP1 PRAP1 CCNG1 CCNG1 USP28 USP28 NOP53 NOP53 G3QSG6_GORGO G3QSG6_GORGO CLOCK CLOCK ABRAXAS1 ABRAXAS1 ATAD5 ATAD5 CLSPN CLSPN G3QTD2_GORGO G3QTD2_GORGO GRB2 GRB2 EME2 EME2 TREX1 TREX1 DOT1L DOT1L CDC5L CDC5L ERCC6 ERCC6 MSH2 MSH2 TAOK1 TAOK1 HUS1B HUS1B BLM BLM RBM38 RBM38 GIGYF2 GIGYF2 G3QYE9_GORGO G3QYE9_GORGO TICRR TICRR BRIP1 BRIP1 CDC14B CDC14B PPM1D PPM1D MUC1 MUC1 FBXO31 FBXO31 FBXO44 FBXO44 SDE2 SDE2 G3R3B3_GORGO G3R3B3_GORGO XPC XPC ATM ATM BID BID ABL1 ABL1 GADD45A GADD45A WNT1 WNT1 EME1 EME1 BABAM2 BABAM2 TAOK2 TAOK2 INTS7 INTS7 DONSON DONSON E2F7 E2F7 PLK2 PLK2 USP10 USP10 TAOK3 TAOK3 CDK1 CDK1 SESN2 SESN2 MRNIP MRNIP NDRG1 NDRG1 RPA2 RPA2 ING4 ING4 G3RJV6_GORGO G3RJV6_GORGO G3RKP6_GORGO G3RKP6_GORGO TOPBP1 TOPBP1 RPL26 RPL26 CHEK1 CHEK1 G3RPM5_GORGO G3RPM5_GORGO TRIAP1 TRIAP1 MFSD11 MFSD11 G3RRP1_GORGO G3RRP1_GORGO CDKN1A CDKN1A RPS6KA6 RPS6KA6 PLK3 PLK3 G3RX40_GORGO G3RX40_GORGO MRE11 MRE11 G3RZZ0_GORGO G3RZZ0_GORGO CRADD CRADD KAT5 KAT5 BABAM1 BABAM1 BRCA1 BRCA1 EIF2AK4 EIF2AK4 PAXIP1 PAXIP1 FOXM1 FOXM1 G3SBE5_GORGO G3SBE5_GORGO NBN NBN HINFP HINFP MIF MIF BRCA2 BRCA2 RPS27L RPS27L PTPN11 PTPN11 RINT1 RINT1 ENSGGOP00000028787 ENSGGOP00000028787 ENSGGOP00000028825 ENSGGOP00000028825 ENSGGOP00000028878 ENSGGOP00000028878 ENSGGOP00000029067 ENSGGOP00000029067 RAD17 RAD17 PIDD1 PIDD1 ENSGGOP00000029568 ENSGGOP00000029568 FOXN3 FOXN3 ENSGGOP00000030111 ENSGGOP00000030111 PPP2R5C PPP2R5C RHNO1 RHNO1 ATF2 ATF2 TIPRL TIPRL CCND1 CCND1 BRCC3 BRCC3 ENSGGOP00000033701 ENSGGOP00000033701 ENSGGOP00000033890 ENSGGOP00000033890 CDK5RAP3 CDK5RAP3 ENSGGOP00000034163 ENSGGOP00000034163 ENSGGOP00000034312 ENSGGOP00000034312 ENSGGOP00000034749 ENSGGOP00000034749 MYO6 MYO6 ENSGGOP00000035693 ENSGGOP00000035693 ENSGGOP00000035698 ENSGGOP00000035698 MUS81 MUS81 ENSGGOP00000036103 ENSGGOP00000036103 ENSGGOP00000036252 ENSGGOP00000036252 ENSGGOP00000036466 ENSGGOP00000036466 ENSGGOP00000036560 ENSGGOP00000036560 ENSGGOP00000037095 ENSGGOP00000037095 ATR ATR ENSGGOP00000038576 ENSGGOP00000038576 RAD9B RAD9B ENSGGOP00000038658 ENSGGOP00000038658 SYF2 SYF2 ENSGGOP00000040711 ENSGGOP00000040711 ATRX ATRX ZNF830 ZNF830 SP100-2 SP100-2 ENSGGOP00000042920 ENSGGOP00000042920 ENSGGOP00000042938 ENSGGOP00000042938 ENSGGOP00000043030 ENSGGOP00000043030 DGKZ DGKZ ENSGGOP00000044043 ENSGGOP00000044043 ENSGGOP00000045437 ENSGGOP00000045437 ENSGGOP00000045449 ENSGGOP00000045449 ENSGGOP00000046562 ENSGGOP00000046562 ENSGGOP00000048172 ENSGGOP00000048172 ENSGGOP00000049072 ENSGGOP00000049072 CDKN1B CDKN1B STK33 STK33 WAC WAC ENSGGOP00000050973 ENSGGOP00000050973 DTL DTL UIMC1 UIMC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
TFAP4Transcription factor AP-4. (338 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
TP53BP1Tumor protein p53 binding protein 1. (1972 aa)
C10H10orf90Chromosome 10 open reading frame 90. (691 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
E2F1E2F transcription factor 1. (437 aa)
G3QMN8_GORGOAlkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (236 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
RAD1RAD1 checkpoint DNA exonuclease. (282 aa)
PRAP1Uncharacterized protein. (150 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1077 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (464 aa)
G3QSG6_GORGOMitogen-activated protein kinase kinase kinase 20. (780 aa)
CLOCKClock circadian regulator. (847 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
ATAD5ATPase family AAA domain containing 5. (1844 aa)
CLSPNClaspin. (1335 aa)
G3QTD2_GORGOProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (375 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1537 aa)
CDC5LCell division cycle 5 like. (805 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1493 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
TAOK1TAO kinase 1. (1001 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (278 aa)
BLMBLM RecQ like helicase. (1415 aa)
RBM38Uncharacterized protein. (158 aa)
GIGYF2GRB10 interacting GYF protein 2. (1318 aa)
G3QYE9_GORGOHistone H2A; Belongs to the histone H2A family. (143 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1911 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
CDC14BCell division cycle 14B. (461 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
FBXO31F-box protein 31. (543 aa)
FBXO44F-box protein 6. (293 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
G3R3B3_GORGOCell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (940 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
TAOK2TAO kinase 2. (1235 aa)
INTS7Integrator complex subunit 7. (962 aa)
DONSONDownstream neighbor of SON. (566 aa)
E2F7E2F transcription factor 7. (911 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
TAOK3TAO kinase 3. (898 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
SESN2Sestrin 2. (480 aa)
MRNIPMRN complex interacting protein. (343 aa)
NDRG1N-myc downstream regulated 1. (394 aa)
RPA2Replication protein A2. (270 aa)
ING4Inhibitor of growth protein. (248 aa)
G3RJV6_GORGOTripartite motif containing 39. (518 aa)
G3RKP6_GORGOFork-head domain-containing protein. (467 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
RPL26Ribosomal protein L26. (145 aa)
CHEK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
G3RRP1_GORGOUncharacterized protein. (270 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
G3RX40_GORGOBR serine/threonine kinase 1. (787 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
G3RZZ0_GORGOCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
PAXIP1PAX interacting protein 1. (981 aa)
FOXM1Forkhead box M1. (763 aa)
G3SBE5_GORGORibosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (459 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa)
HINFPHistone H4 transcription factor. (517 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
BRCA2BRCA2 DNA repair associated. (3416 aa)
RPS27L40S ribosomal protein S27. (96 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
RINT1RAD50 interactor 1. (792 aa)
ENSGGOP00000028787MPN domain-containing protein. (307 aa)
ENSGGOP00000028825BRCT domain-containing protein. (83 aa)
ENSGGOP00000028878Forkhead box O4. (505 aa)
ENSGGOP00000029067KOW domain-containing protein. (138 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
ENSGGOP00000029568IZUMO family member 4. (247 aa)
FOXN3Forkhead box N3. (490 aa)
ENSGGOP00000030111Protein kinase domain-containing protein. (210 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (472 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TIPRLTOR signaling pathway regulator. (272 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (317 aa)
ENSGGOP00000033701Uncharacterized protein. (503 aa)
ENSGGOP00000033890NIMA related kinase 11. (645 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (531 aa)
ENSGGOP00000034163Uncharacterized protein. (485 aa)
ENSGGOP00000034312FA complementation group D2. (1390 aa)
ENSGGOP00000034749Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
ENSGGOP00000035693Pre-mRNA processing factor 19. (524 aa)
ENSGGOP00000035698Uncharacterized protein. (301 aa)
MUS81MUS81 structure-specific endonuclease subunit. (570 aa)
ENSGGOP00000036103Uncharacterized protein. (509 aa)
ENSGGOP00000036252Uncharacterized protein. (56 aa)
ENSGGOP00000036466Checkpoint kinase 2. (529 aa)
ENSGGOP00000036560TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (284 aa)
ENSGGOP00000037095Uncharacterized protein. (575 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ENSGGOP00000038576Centrosomal protein 63. (703 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa)
ENSGGOP00000038658ANK_REP_REGION domain-containing protein. (398 aa)
SYF2SYF2 pre-mRNA splicing factor. (243 aa)
ENSGGOP00000040711ATR interacting protein. (799 aa)
ATRXATRX chromatin remodeler. (2492 aa)
ZNF830Zinc finger protein 830. (372 aa)
SP100-2SP100 nuclear antigen. (885 aa)
ENSGGOP00000042920Mitotic arrest deficient 2 like 2. (241 aa)
ENSGGOP00000042938Checkpoint protein; Belongs to the HUS1 family. (273 aa)
ENSGGOP00000043030Serine/threonine-protein kinase PLK. (624 aa)
DGKZDiacylglycerol kinase. (1117 aa)
ENSGGOP00000044043Uncharacterized protein. (100 aa)
ENSGGOP00000045437Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (575 aa)
ENSGGOP00000045449USP domain-containing protein; Belongs to the peptidase C19 family. (290 aa)
ENSGGOP00000046562TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (261 aa)
ENSGGOP00000048172Uncharacterized protein. (482 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
CDKN1BUncharacterized protein. (205 aa)
STK33Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa)
WACWW domain containing adaptor with coiled-coil. (666 aa)
ENSGGOP00000050973Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
UIMC1Ubiquitin interaction motif containing 1. (720 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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