(35 nodes) Regulation of mast cell degranulation network (Gorilla gorilla)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
	SNX4	Sorting nexin 4. (450 aa)
	ENSGGOP00000040205	Galectin. (355 aa)
	ENSGGOP00000040502	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (546 aa)
	ENSGGOP00000044715	FCH domain-containing protein. (121 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
	ENSGGOP00000048996	Ig-like domain-containing protein. (180 aa)
	ENSGGOP00000049861	Uncharacterized protein; Belongs to the synaptobrevin family. (230 aa)
	ENSGGOP00000052295	A20-type domain-containing protein. (104 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	G3R475_GORGO	RAB guanine nucleotide exchange factor 1. (469 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	GATA2	GATA binding protein 2. (480 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	IL4R	Interleukin 4 receptor. (825 aa)
	CD300A	CD300a molecule. (299 aa)
	STXBP2	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (652 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	FGR	Tyrosine-protein kinase. (529 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	IL13RA2	Interleukin 13 receptor subunit alpha 2. (380 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	GAB4	GRB2 associated binding protein family member 4. (575 aa)
	G3RBI2_GORGO	Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (827 aa)
	BLK	Tyrosine-protein kinase. (446 aa)
	GATA1	GATA binding protein 1. (413 aa)
	G3RT65_GORGO	Sphingosine kinase 2. (663 aa)
	G3RTS2_GORGO	A20-type domain-containing protein. (118 aa)
	PLA2G3	Phospholipase A2 group III. (539 aa)
	G3RXW1_GORGO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
	FOXF1	Uncharacterized protein. (207 aa)
	PDPK1	Protein kinase domain-containing protein. (347 aa)
	UNC13D	Unc-13 homolog D. (1090 aa)
	C12H12orf4	Chromosome 12 open reading frame 4. (552 aa)
	VAMP8	V-SNARE coiled-coil homology domain-containing protein. (113 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLK	FES	ENSGGOP00000017853	ENSGGOP00000038384	Tyrosine-protein kinase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.417
BLK	SYK	ENSGGOP00000017853	ENSGGOP00000010128	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.489
ENSGGOP00000040502	VAMP8	ENSGGOP00000040502	ENSGGOP00000037617	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	V-SNARE coiled-coil homology domain-containing protein.	0.674
ENSGGOP00000049861	ENSGGOP00000052295	ENSGGOP00000049861	ENSGGOP00000052295	Uncharacterized protein; Belongs to the synaptobrevin family.	A20-type domain-containing protein.	0.514
ENSGGOP00000049861	G3R475_GORGO	ENSGGOP00000049861	ENSGGOP00000010066	Uncharacterized protein; Belongs to the synaptobrevin family.	RAB guanine nucleotide exchange factor 1.	0.514
ENSGGOP00000049861	G3RTS2_GORGO	ENSGGOP00000049861	ENSGGOP00000019199	Uncharacterized protein; Belongs to the synaptobrevin family.	A20-type domain-containing protein.	0.514
ENSGGOP00000049861	SNX4	ENSGGOP00000049861	ENSGGOP00000039063	Uncharacterized protein; Belongs to the synaptobrevin family.	Sorting nexin 4.	0.740
ENSGGOP00000049861	VAMP8	ENSGGOP00000049861	ENSGGOP00000037617	Uncharacterized protein; Belongs to the synaptobrevin family.	V-SNARE coiled-coil homology domain-containing protein.	0.831
ENSGGOP00000052295	ENSGGOP00000049861	ENSGGOP00000052295	ENSGGOP00000049861	A20-type domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.514
ENSGGOP00000052295	G3R475_GORGO	ENSGGOP00000052295	ENSGGOP00000010066	A20-type domain-containing protein.	RAB guanine nucleotide exchange factor 1.	0.537
ENSGGOP00000052295	G3RTS2_GORGO	ENSGGOP00000052295	ENSGGOP00000019199	A20-type domain-containing protein.	A20-type domain-containing protein.	0.543
FES	BLK	ENSGGOP00000038384	ENSGGOP00000017853	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	Tyrosine-protein kinase.	0.417
FES	FGR	ENSGGOP00000038384	ENSGGOP00000000763	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	Tyrosine-protein kinase.	0.422
FGR	FES	ENSGGOP00000000763	ENSGGOP00000038384	Tyrosine-protein kinase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.422
FGR	LYN	ENSGGOP00000000763	ENSGGOP00000012189	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.767
FGR	SYK	ENSGGOP00000000763	ENSGGOP00000010128	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.702
G3R475_GORGO	ENSGGOP00000049861	ENSGGOP00000010066	ENSGGOP00000049861	RAB guanine nucleotide exchange factor 1.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.514
G3R475_GORGO	ENSGGOP00000052295	ENSGGOP00000010066	ENSGGOP00000052295	RAB guanine nucleotide exchange factor 1.	A20-type domain-containing protein.	0.537
G3R475_GORGO	G3RTS2_GORGO	ENSGGOP00000010066	ENSGGOP00000019199	RAB guanine nucleotide exchange factor 1.	A20-type domain-containing protein.	0.537
G3RTS2_GORGO	ENSGGOP00000049861	ENSGGOP00000019199	ENSGGOP00000049861	A20-type domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.514