STRINGSTRING
G3QYD4_GORGO G3QYD4_GORGO SLC1A1 SLC1A1 CX3CL1 CX3CL1 VSTM2L VSTM2L ZPR1 ZPR1 PLXND1 PLXND1 BCL2 BCL2 SIX1 SIX1 AGAP2 AGAP2 TGFB3 TGFB3 NRP1 NRP1 G3QHK0_GORGO G3QHK0_GORGO PSEN1 PSEN1 TERT TERT ADNP ADNP WFS1 WFS1 TFAP2D TFAP2D IL6ST IL6ST HIPK2 HIPK2 G3QR56_GORGO G3QR56_GORGO G3QRG5_GORGO G3QRG5_GORGO ARRB2 ARRB2 MT3 MT3 G3QTH4_GORGO G3QTH4_GORGO NONO NONO CNTFR CNTFR GCLC GCLC MSH2 MSH2 HYOU1 HYOU1 SOD2 SOD2 CLCF1 CLCF1 HDGF HDGF BARHL1 BARHL1 NDNF NDNF CHL1 CHL1 AARS-2 AARS-2 NFATC4 NFATC4 HSP90AB1 HSP90AB1 TOX3 TOX3 PIK3CA PIK3CA SLC30A10 SLC30A10 ISL1 ISL1 ROCK1 ROCK1 FGF20 FGF20 PPARGC1A PPARGC1A SIX4 SIX4 CPEB4 CPEB4 BAX BAX F2R F2R RETREG1 RETREG1 G3R515_GORGO G3R515_GORGO CRLF1 CRLF1 ALKBH1 ALKBH1 NR4A2 NR4A2 IL27RA IL27RA G3R8T5_GORGO G3R8T5_GORGO VEGFB VEGFB ADORA2A ADORA2A CORO1A CORO1A KDR KDR RHOA RHOA KIF14 KIF14 THAP11 THAP11 MTNR1B MTNR1B G3RDS9_GORGO G3RDS9_GORGO NTRK2 NTRK2 G3RF14_GORGO G3RF14_GORGO PINK1 PINK1 DNAJC5B DNAJC5B TFAP2B TFAP2B FGF8 FGF8 G3RHL0_GORGO G3RHL0_GORGO PTK2B PTK2B G3RI71_GORGO G3RI71_GORGO GRN GRN SNCB SNCB CCL2 CCL2 GCLM GCLM G3RM60_GORGO G3RM60_GORGO NEFL NEFL G3RRQ8_GORGO G3RRQ8_GORGO G3RSQ1_GORGO G3RSQ1_GORGO G3RT38_GORGO G3RT38_GORGO G3RTH8_GORGO G3RTH8_GORGO G3RUR9_GORGO G3RUR9_GORGO G3RX18_GORGO G3RX18_GORGO PLA2G3 PLA2G3 STAMBP STAMBP EN1 EN1 UNC5B UNC5B BCL2L1 BCL2L1 G3RZZ0_GORGO G3RZZ0_GORGO GFRAL GFRAL NES NES AMBRA1 AMBRA1 LIG4 LIG4 MDK MDK ANGPT1 ANGPT1 CNTF CNTF MAP3K12 MAP3K12 FAIM2 FAIM2 EN2 EN2 BRAF BRAF G3SBR2_GORGO G3SBR2_GORGO GBE1 GBE1 NRBP2 NRBP2 SNCA SNCA PTPRZ1 PTPRZ1 HIF1A HIF1A CX3CR1 CX3CR1 ENSGGOP00000029038 ENSGGOP00000029038 ENSGGOP00000029762 ENSGGOP00000029762 ENSGGOP00000030478 ENSGGOP00000030478 SEMA3E SEMA3E ENSGGOP00000031074 ENSGGOP00000031074 ENSGGOP00000031261 ENSGGOP00000031261 VPS54 VPS54 DNAJC5 DNAJC5 BDNF BDNF SNX6 SNX6 ENSGGOP00000032639 ENSGGOP00000032639 CCND1 CCND1 CLN8 CLN8 ENSGGOP00000033030 ENSGGOP00000033030 GPI GPI NGF NGF ENSGGOP00000034632 ENSGGOP00000034632 PRKCG PRKCG ENSGGOP00000035777 ENSGGOP00000035777 ENSGGOP00000036938 ENSGGOP00000036938 OXR1 OXR1 ERBB3 ERBB3 ENSGGOP00000037735 ENSGGOP00000037735 PRKN PRKN HRAS HRAS ENSGGOP00000039368 ENSGGOP00000039368 KDM2B KDM2B NTRK1 NTRK1 ENSGGOP00000040207 ENSGGOP00000040207 ENSGGOP00000040502 ENSGGOP00000040502 RASA1 RASA1 ENSGGOP00000041746 ENSGGOP00000041746 NAIP NAIP GRIK2 GRIK2 SOD1 SOD1 NTF3 NTF3 ENSGGOP00000044534 ENSGGOP00000044534 MECP2 MECP2 CEBPB CEBPB ENSGGOP00000045423 ENSGGOP00000045423 BOK BOK HMOX1 HMOX1 GABRA5 GABRA5 CITED1 CITED1 XRCC2 XRCC2 FZD9 FZD9 ENSGGOP00000048403 ENSGGOP00000048403 DLX1 DLX1 MAG MAG ENSGGOP00000049122 ENSGGOP00000049122 GDNF GDNF ENSGGOP00000049514 ENSGGOP00000049514 ENSGGOP00000050481 ENSGGOP00000050481 ENSGGOP00000050656 ENSGGOP00000050656 ENSGGOP00000051849 ENSGGOP00000051849
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QYD4_GORGOKRAS proto-oncogene, GTPase. (189 aa)
SLC1A1Amino acid transporter. (524 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (202 aa)
ZPR1ZPR1 zinc finger. (459 aa)
PLXND1Plexin D1. (1925 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SIX1Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] (284 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1080 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
G3QHK0_GORGOBTG anti-proliferation factor 2. (158 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
TFAP2DTranscription factor AP-2 delta. (452 aa)
IL6STFibronectin type-III domain-containing protein. (329 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
G3QR56_GORGODNA repair protein XRCC4. (336 aa)
G3QRG5_GORGONeurotrophin 4; Belongs to the NGF-beta family. (210 aa)
ARRB2Arrestin beta 2. (409 aa)
MT3Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
G3QTH4_GORGOUncharacterized protein. (280 aa)
NONOUncharacterized protein. (441 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (234 aa)
CLCF1Uncharacterized protein. (322 aa)
HDGFHeparin binding growth factor. (256 aa)
BARHL1BarH like homeobox 1. (327 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
AARS-2Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (878 aa)
NFATC4Nuclear factor of activated T cells 4. (920 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TOX3TOX high mobility group box family member 3. (576 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
ISL1ISL LIM homeobox 1. (351 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
SIX4SIX homeobox 4. (677 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
RETREG1Reticulophagy regulator 1. (497 aa)
G3R515_GORGOProtein kinase C iota. (557 aa)
CRLF1Cytokine receptor like factor 1. (383 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RHOAUncharacterized protein. (179 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
THAP11THAP domain containing 11. (304 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
G3RDS9_GORGOLysine demethylase 2B. (1252 aa)
NTRK2Tyrosine-protein kinase receptor. (767 aa)
G3RF14_GORGOGamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
PINK1PTEN induced kinase 1. (581 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
G3RHL0_GORGOGrowth differentiation factor 5. (501 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
G3RI71_GORGONACHT domain-containing protein. (1127 aa)
GRNGranulin precursor. (593 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
CCL2C-C motif chemokine. (99 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
G3RM60_GORGOSynaptic Ras GTPase activating protein 1. (1329 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
G3RRQ8_GORGOAXL receptor tyrosine kinase. (843 aa)
G3RSQ1_GORGOLegumain. (433 aa)
G3RT38_GORGOADAM metallopeptidase domain 8. (824 aa)
G3RTH8_GORGOPOU domain protein. (259 aa)
G3RUR9_GORGOForkhead box B1. (279 aa)
G3RX18_GORGOUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (805 aa)
PLA2G3Phospholipase A2 group III. (539 aa)
STAMBPSTAM binding protein. (424 aa)
EN1Homeobox protein engrailed-like. (395 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
BCL2L1BCL2 like 1. (233 aa)
G3RZZ0_GORGOCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
GFRALGDNF family receptor alpha like. (394 aa)
NESNestin; Belongs to the intermediate filament family. (1620 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
LIG4DNA ligase. (911 aa)
MDKMidkine. (143 aa)
ANGPT1Angiopoietin 1. (498 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
EN2Homeobox protein engrailed-like. (221 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
G3SBR2_GORGOUncharacterized protein. (289 aa)
GBE11,4-alpha-glucan branching enzyme 1. (702 aa)
NRBP2Nuclear receptor binding protein 2. (499 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2316 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
ENSGGOP00000029038TYRO3 protein tyrosine kinase. (901 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ENSGGOP00000031074Uncharacterized protein. (55 aa)
ENSGGOP00000031261Myocyte enhancer factor 2C. (483 aa)
VPS54VPS54 subunit of GARP complex. (977 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (418 aa)
ENSGGOP00000032639Uncharacterized protein. (387 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
ENSGGOP00000033030Palmitoyl-protein thioesterase 1. (335 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (573 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
ENSGGOP00000034632Recep_L_domain domain-containing protein. (183 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
ENSGGOP00000035777Baculoviral IAP repeat containing 5. (165 aa)
ENSGGOP00000036938TLDc domain-containing protein. (119 aa)
OXR1Oxidation resistance 1. (874 aa)
ERBB3Protein kinase domain-containing protein. (593 aa)
ENSGGOP00000037735Uncharacterized protein. (471 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSGGOP00000039368RRM domain-containing protein. (153 aa)
KDM2BJmjC domain-containing protein. (79 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
ENSGGOP00000040502Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (546 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
ENSGGOP00000041746Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa)
NAIPUncharacterized protein. (198 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
ENSGGOP00000044534Protein kinase domain-containing protein. (363 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ENSGGOP00000045423Homeobox domain-containing protein. (228 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
XRCC2X-ray repair cross complementing 2. (283 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ENSGGOP00000048403Lep_receptor_Ig domain-containing protein. (92 aa)
DLX1Distal-less homeobox 1. (255 aa)
MAGMyelin associated glycoprotein. (626 aa)
ENSGGOP00000049122Uncharacterized protein. (305 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
ENSGGOP00000049514Uncharacterized protein. (412 aa)
ENSGGOP00000050481Uncharacterized protein. (441 aa)
ENSGGOP00000050656Battenin. (447 aa)
ENSGGOP00000051849Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (381 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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