107 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1834 aa)
	PTTG1	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa)
	SEPTIN1	Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (368 aa)
	ANKRD31	Ankyrin repeat domain 31. (1880 aa)
	G3RP17_GORGO	Structural maintenance of chromosomes protein. (1175 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (838 aa)
	RNF212	Ring finger protein 212. (297 aa)
	G3RYI7_GORGO	Telomere repeat binding bouquet formation protein 2. (192 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	TOP2B	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1562 aa)
	PRDM9	PR/SET domain 9. (822 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
	G3S5H5_GORGO	Uncharacterized protein. (838 aa)
	SYCE2	Uncharacterized protein. (126 aa)
	G3SB61_GORGO	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa)
	ACTR3	Actin related protein 3; Belongs to the actin family. (418 aa)
	STAG3	Stromal antigen 3. (1221 aa)
	G3SH23_GORGO	Uncharacterized protein. (193 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3179 aa)
	G3SJX1_GORGO	Uncharacterized protein; Belongs to the actin family. (353 aa)
	ACTR3B	Uncharacterized protein; Belongs to the actin family. (221 aa)
	MAJIN	Uncharacterized protein. (176 aa)
	ENSGGOP00000030111	Protein kinase domain-containing protein. (210 aa)
	SPATA22	Spermatogenesis associated 22. (363 aa)
	ENSGGOP00000032803	MutS homolog 4. (844 aa)
	ENSGGOP00000032912	Uncharacterized protein; Belongs to the actin family. (386 aa)
	ENSGGOP00000034312	FA complementation group D2. (1390 aa)
	ENSGGOP00000035259	Structural maintenance of chromosomes 1A. (1096 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (570 aa)
	ENSGGOP00000036407	Centromere protein X. (122 aa)
	ENSGGOP00000036645	Uncharacterized protein. (182 aa)
	ENSGGOP00000036812	HORMA domain-containing protein. (363 aa)
	STAG1	Stromal antigen 1. (1258 aa)
	SGO2	Shugoshin 2. (1266 aa)
	PTTG2	Pituitary tumor-transforming 2. (196 aa)
	M1AP	Meiosis 1 associated protein. (530 aa)
	ENSGGOP00000039935	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
	SYCP2	Synaptonemal complex protein 2. (1530 aa)
	RAD51C	Uncharacterized protein. (52 aa)
	BAG6	BCL2 associated athanogene 6. (1190 aa)
	ENSGGOP00000041237	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (377 aa)
	SUN1	MRP domain-containing protein. (168 aa)
	ENSGGOP00000043030	Serine/threonine-protein kinase PLK. (624 aa)
	CCDC36	Coiled-coil domain containing 36. (595 aa)
	CORT	Somatostatin domain-containing protein. (143 aa)
	ENSGGOP00000044817	MutL homolog 3. (1410 aa)
	ENSGGOP00000046210	annotation not available (52 aa)
	NCAPH	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
	SMC2	Structural maintenance of chromosomes protein. (1197 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (385 aa)
	TEX11	Testis expressed 11. (940 aa)
	HORMAD1	HORMA domain containing 1. (394 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa)
	HFM1	Helicase for meiosis 1. (1435 aa)
	HORMAD2	HORMA domain containing 2. (307 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1267 aa)
	MEIKIN	Meiotic kinetochore factor. (373 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (437 aa)
	CENPC	Centromere protein C. (943 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	TTK	TTK protein kinase. (856 aa)
	FANCM	FA complementation group M. (2048 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	G3QZ33_GORGO	Uncharacterized protein; Belongs to the AAA ATPase family. (362 aa)
	NUF2	NUF2 component of NDC80 kinetochore complex. (464 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	C1H1orf146	Chromosome 1 open reading frame 146. (180 aa)
	SGO1	Shugoshin 1. (527 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (375 aa)
	ANKLE1	Ankyrin repeat and LEM domain containing 1. (643 aa)
	ZCWPW1	Zinc finger CW-type and PWWP domain containing 1. (648 aa)
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	STAG2	Stromal antigen 2. (1268 aa)
	SYCE1	Synaptonemal complex central element protein 1. (351 aa)
	TERB1	Telomere repeat binding bouquet formation protein 1. (727 aa)
	SYCE3	Synaptonemal complex central element protein 3. (88 aa)
	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa)
	G3QIE9_GORGO	Uncharacterized protein. (202 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2120 aa)
	SHOC1	Shortage in chiasmata 1. (1408 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
	C14H14orf39	Chromosome 14 open reading frame 39. (587 aa)
	G3QFD4_GORGO	Formin 2. (1532 aa)
	PSMC3IP	PSMC3 interacting protein. (217 aa)
	G3R5X1_GORGO	Non-SMC condensin II complex subunit H2. (546 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (571 aa)
	G3R6T7_GORGO	DNA_MISMATCH_REPAIR_2 domain-containing protein. (839 aa)
	RAD21	RAD21 cohesin complex component. (631 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (952 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (526 aa)
	G3RA70_GORGO	SUN domain-containing protein. (653 aa)
	SYCE1L	Uncharacterized protein. (212 aa)
	SMC4	Structural maintenance of chromosomes protein. (1288 aa)
	SIRT7	Sirtuin 7. (400 aa)
	RMI1	RecQ mediated genome instability 1. (625 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	NDC1	NDC1 transmembrane nucleoporin. (674 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	G3RHR8_GORGO	Synaptonemal complex protein 1. (942 aa)
	REC8	REC8 meiotic recombination protein. (547 aa)
	MLH1	MutL homolog 1. (756 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	ACTR3B	ENSGGOP00000025781	ENSGGOP00000028592	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.937
ACTR3	ENSGGOP00000032912	ENSGGOP00000025781	ENSGGOP00000032912	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.999
ACTR3	G3QFD4_GORGO	ENSGGOP00000025781	ENSGGOP00000001003	Actin related protein 3; Belongs to the actin family.	Formin 2.	0.529
ACTR3	G3SH23_GORGO	ENSGGOP00000025781	ENSGGOP00000027411	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein.	0.813
ACTR3	G3SJX1_GORGO	ENSGGOP00000025781	ENSGGOP00000028413	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.995
ACTR3B	ACTR3	ENSGGOP00000028592	ENSGGOP00000025781	Uncharacterized protein; Belongs to the actin family.	Actin related protein 3; Belongs to the actin family.	0.937
ACTR3B	ENSGGOP00000032912	ENSGGOP00000028592	ENSGGOP00000032912	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.991
ACTR3B	G3SJX1_GORGO	ENSGGOP00000028592	ENSGGOP00000028413	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.910
ANKRD31	CCDC36	ENSGGOP00000016643	ENSGGOP00000043640	Ankyrin repeat domain 31.	Coiled-coil domain containing 36.	0.672
ANKRD31	G3RHR8_GORGO	ENSGGOP00000016643	ENSGGOP00000015196	Ankyrin repeat domain 31.	Synaptonemal complex protein 1.	0.404
ANKRD31	MEI4	ENSGGOP00000016643	ENSGGOP00000046511	Ankyrin repeat domain 31.	Meiotic double-stranded break formation protein 4.	0.564
ANKRD31	PRDM9	ENSGGOP00000016643	ENSGGOP00000022130	Ankyrin repeat domain 31.	PR/SET domain 9.	0.470
ATM	BRIP1	ENSGGOP00000010144	ENSGGOP00000008668	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 interacting protein C-terminal helicase 1.	0.910
ATM	DMC1	ENSGGOP00000010144	ENSGGOP00000010934	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.905
ATM	EME1	ENSGGOP00000010144	ENSGGOP00000011019	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Essential meiotic structure-specific endonuclease 1.	0.626
ATM	EME2	ENSGGOP00000010144	ENSGGOP00000006103	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Essential meiotic structure-specific endonuclease subunit 2.	0.407
ATM	ENSGGOP00000032803	ENSGGOP00000010144	ENSGGOP00000032803	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutS homolog 4.	0.645
ATM	ENSGGOP00000034312	ENSGGOP00000010144	ENSGGOP00000034312	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group D2.	0.864
ATM	ENSGGOP00000035259	ENSGGOP00000010144	ENSGGOP00000035259	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Structural maintenance of chromosomes 1A.	0.682
ATM	ENSGGOP00000043030	ENSGGOP00000010144	ENSGGOP00000043030	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase PLK.	0.554