STRINGSTRING
GDF7 GDF7 SPDEF SPDEF G3QDY6_GORGO G3QDY6_GORGO LATS1 LATS1 G3QD16_GORGO G3QD16_GORGO EDNRA EDNRA BCL2 BCL2 IL6R IL6R WNT10A WNT10A G3QF38_GORGO G3QF38_GORGO ATOH1 ATOH1 HOXC10 HOXC10 TBX19 TBX19 HOXD10 HOXD10 STAT6 STAT6 NRP1 NRP1 OLIG3 OLIG3 EBF2 EBF2 G3QH03_GORGO G3QH03_GORGO SFRP2 SFRP2 TEAD3 TEAD3 PRDM1 PRDM1 GLI3 GLI3 MYOG MYOG PSEN1 PSEN1 TBX21 TBX21 HOXA2 HOXA2 NOTCH3 NOTCH3 BATF BATF NOTCH4 NOTCH4 NODAL NODAL HEY2 HEY2 APC2 APC2 RARA RARA EYA1 EYA1 SMO SMO WNT6 WNT6 WNT2B WNT2B NOTCH2 NOTCH2 G3QN85_GORGO G3QN85_GORGO WNT8A WNT8A NEUROD4 NEUROD4 MYF5 MYF5 MYF6 MYF6 WNT9A WNT9A G3QPJ0_GORGO G3QPJ0_GORGO SPN SPN FGF10 FGF10 ONECUT1 ONECUT1 SMAD2 SMAD2 PITX1 PITX1 MYL2 MYL2 GSX1 GSX1 DLX2 DLX2 HOXA13 HOXA13 G3QRG5_GORGO G3QRG5_GORGO MNX1 MNX1 ASCL1 ASCL1 DLL1 DLL1 G3QS60_GORGO G3QS60_GORGO ARHGEF2 ARHGEF2 G3QTD2_GORGO G3QTD2_GORGO GATA2 GATA2 GATA3 GATA3 DSCAML1 DSCAML1 GCM1 GCM1 WNT3 WNT3 G3QV14_GORGO G3QV14_GORGO G3QW78_GORGO G3QW78_GORGO KIAA1549 KIAA1549 WNT5A WNT5A G3QXA1_GORGO G3QXA1_GORGO TBXT TBXT PRADC1 PRADC1 GSC GSC GSX2 GSX2 DHH DHH NKX2-2 NKX2-2 G3QZ51_GORGO G3QZ51_GORGO EOMES EOMES HES1 HES1 SIX2 SIX2 BARHL2 BARHL2 TBX22 TBX22 TBX2 TBX2 TBX1 TBX1 G3R1I7_GORGO G3R1I7_GORGO FOXN4 FOXN4 ISL1 ISL1 GLI2 GLI2 FOXN1 FOXN1 WNT2 WNT2 FGF13 FGF13 NOTCH1 NOTCH1 G3R3B7_GORGO G3R3B7_GORGO NR2E1 NR2E1 PRRX1 PRRX1 PDPN PDPN PAX6 PAX6 G3R439_GORGO G3R439_GORGO MTOR MTOR G3R5D7_GORGO G3R5D7_GORGO FEV FEV SOX6 SOX6 SPRY2 SPRY2 WNT10B WNT10B WNT1 WNT1 PRDM14 PRDM14 CTR9 CTR9 LATS2 LATS2 G3R7P4_GORGO G3R7P4_GORGO TOX TOX LBX1 LBX1 WNT7A WNT7A SOX13 SOX13 KDR KDR RHOA RHOA TBX6 TBX6 DMRT3 DMRT3 EDN1 EDN1 TBX15 TBX15 RTF1 RTF1 SMAD4 SMAD4 CDON CDON TBX5 TBX5 TBX4 TBX4 SHH SHH LHX3 LHX3 G3RF44_GORGO G3RF44_GORGO WNT8B WNT8B DBX1 DBX1 BMP4 BMP4 MESP1 MESP1 WNT11 WNT11 FGF8 FGF8 PROX1 PROX1 KDM6B KDM6B ETS2 ETS2 NKX6-3 NKX6-3 MCL1 MCL1 SOX5 SOX5 WNT16 WNT16 G3RKF1_GORGO G3RKF1_GORGO GBX1 GBX1 NKX2-5 NKX2-5 SOX9 SOX9 G3RNC1_GORGO G3RNC1_GORGO NEUROG1 NEUROG1 NEUROD1 NEUROD1 G3RPM5_GORGO G3RPM5_GORGO G3RPS4_GORGO G3RPS4_GORGO APC APC IL6 IL6 TBR1 TBR1 GATA1 GATA1 BCL11B BCL11B G3RTC0_GORGO G3RTC0_GORGO G3RTH8_GORGO G3RTH8_GORGO TBX20 TBX20 SMAD5 SMAD5 RAB10 RAB10 G3RWH6_GORGO G3RWH6_GORGO STAT3 STAT3 G3RXP9_GORGO G3RXP9_GORGO JAG1 JAG1 FOXA2 FOXA2 TBX10 TBX10 GATA6 GATA6 ONECUT2 ONECUT2 G3RZJ6_GORGO G3RZJ6_GORGO BMP2 BMP2 CASP3 CASP3 SOX8 SOX8 VWA5A VWA5A IFRD1 IFRD1 MYOD1 MYOD1 SOX17 SOX17 MYT1L MYT1L ZNF521 ZNF521 ENSGGOP00000024523 ENSGGOP00000024523 FEZF2 FEZF2 G3S9R1_GORGO G3S9R1_GORGO G3S9W2_GORGO G3S9W2_GORGO BRAF BRAF ARX ARX SMAD1 SMAD1 GAS1 GAS1 G3SEM1_GORGO G3SEM1_GORGO ISL2 ISL2 G3SIC3_GORGO G3SIC3_GORGO RAG2 RAG2 KLF4 KLF4 HOXA11 HOXA11 GAP43 GAP43 G3SK49_GORGO G3SK49_GORGO DLL4 DLL4 EYA2 EYA2 DOCK7 DOCK7 FKBP8 FKBP8 ENSGGOP00000031261 ENSGGOP00000031261 CDC73 CDC73 TGFB1I1 TGFB1I1 PPARG PPARG ENSGGOP00000032627 ENSGGOP00000032627 WT1 WT1 ENSGGOP00000033344 ENSGGOP00000033344 DMRTA2 DMRTA2 TAL1 TAL1 EPAS1 EPAS1 VWA5B2 VWA5B2 TM2D3 TM2D3 ITGB1 ITGB1 SLAMF8 SLAMF8 WNT7B WNT7B ENSGGOP00000036799 ENSGGOP00000036799 WNT9B WNT9B ENSGGOP00000037735 ENSGGOP00000037735 TBX3 TBX3 MITF MITF ACVR1 ACVR1 ENSGGOP00000041335 ENSGGOP00000041335 WNT5B WNT5B NRG1 NRG1 TCF7L2 TCF7L2 ENSGGOP00000042355 ENSGGOP00000042355 PAF1 PAF1 ERBB4 ERBB4 PTCH2 PTCH2 RBPJ RBPJ CDC42 CDC42 NTF3 NTF3 ENSGGOP00000045127 ENSGGOP00000045127 PTCH1 PTCH1 WNT4 WNT4 ENSGGOP00000047870 ENSGGOP00000047870 IRF4 IRF4 DLX1 DLX1 CTNNB1 CTNNB1 SFRP1 SFRP1 IHH IHH RUNX2 RUNX2 EHMT2 EHMT2 ENSGGOP00000050768 ENSGGOP00000050768 TGFBR1 TGFBR1 ENSGGOP00000051392 ENSGGOP00000051392
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF7Growth differentiation factor 7. (447 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
G3QDY6_GORGOInterleukin 7. (179 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
G3QD16_GORGOGATA binding protein 5. (395 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IL6RInterleukin 6 receptor. (468 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
G3QF38_GORGOForkhead box P3. (441 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
HOXC10Homeobox C10. (342 aa)
TBX19T-box transcription factor 19. (448 aa)
HOXD10Homeobox D10. (340 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
EBF2EBF transcription factor 2. (575 aa)
G3QH03_GORGOMAX dimerization protein MGA. (3006 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
PRDM1PR/SET domain 1. (825 aa)
GLI3GLI family zinc finger 3. (1580 aa)
MYOGMyogenin. (249 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa)
TBX21T-box transcription factor 21. (535 aa)
HOXA2Homeobox A2. (375 aa)
NOTCH3Notch receptor 3. (2317 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
NOTCH4Notch receptor 4. (2003 aa)
NODALNodal growth differentiation factor. (347 aa)
HEY2Orange domain-containing protein. (257 aa)
APC2APC regulator of WNT signaling pathway 2. (2289 aa)
RARAUncharacterized protein. (624 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
NOTCH2Notch receptor 2. (2373 aa)
G3QN85_GORGOSLAM family member 6. (331 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
MYF6Myogenic factor 6. (242 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
G3QPJ0_GORGOCytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
SPNSialophorin. (399 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ONECUT1One cut domain family member. (465 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PITX1Homeobox protein. (314 aa)
MYL2Myosin light chain 2. (166 aa)
GSX1GS homeobox 1. (264 aa)
DLX2Distal-less homeobox 2. (328 aa)
HOXA13Homeobox domain-containing protein. (219 aa)
G3QRG5_GORGONeurotrophin 4; Belongs to the NGF-beta family. (210 aa)
MNX1Homeobox domain-containing protein. (188 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
G3QS60_GORGOLymphocyte antigen 9. (655 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
G3QTD2_GORGOProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa)
GATA2GATA binding protein 2. (480 aa)
GATA3GATA binding protein 3. (444 aa)
DSCAML1DS cell adhesion molecule like 1. (2113 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
G3QV14_GORGOPOU domain protein. (690 aa)
G3QW78_GORGOProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
KIAA1549KIAA1549. (1927 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
G3QXA1_GORGODelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1199 aa)
TBXTT-box transcription factor T. (435 aa)
PRADC1Protease associated domain containing 1. (188 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
GSX2GS homeobox 2. (304 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
NKX2-2NK2 homeobox 2. (273 aa)
G3QZ51_GORGOFibroblast growth factor receptor. (822 aa)
EOMESEomesodermin. (705 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SIX2SIX homeobox 2. (291 aa)
BARHL2Homeobox domain-containing protein. (314 aa)
TBX22T-box transcription factor 22. (520 aa)
TBX2T-box transcription factor 2. (580 aa)
TBX1Uncharacterized protein. (311 aa)
G3R1I7_GORGOElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
FOXN4Forkhead box N4. (517 aa)
ISL1ISL LIM homeobox 1. (351 aa)
GLI2GLI family zinc finger 2. (1537 aa)
FOXN1Forkhead box N1. (648 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
NOTCH1Uncharacterized protein. (1606 aa)
G3R3B7_GORGOETS variant 2. (370 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
PRRX1Paired related homeobox 1. (245 aa)
PDPNPodoplanin. (237 aa)
PAX6Uncharacterized protein. (475 aa)
G3R439_GORGOHes family bHLH transcription factor 5. (165 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
G3R5D7_GORGOUncharacterized protein. (366 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
SOX6SRY-box transcription factor 6. (829 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PRDM14PR/SET domain 14. (571 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
G3R7P4_GORGOTeneurin transmembrane protein 4. (2690 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
LBX1Ladybird homeobox 1. (281 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (345 aa)
SOX13SRY-box transcription factor 13. (622 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RHOAUncharacterized protein. (179 aa)
TBX6T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). (436 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
EDN1Endothelin 1. (212 aa)
TBX15T-box transcription factor 15. (602 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDONCell adhesion associated, oncogene regulated. (1264 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX4T-box transcription factor 4. (545 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
LHX3LIM homeobox 3. (400 aa)
G3RF44_GORGOForkhead box C2. (442 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DBX1Developing brain homeobox 1. (344 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (266 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PROX1Prospero homeobox 1. (737 aa)
KDM6BLysine demethylase 6B. (1687 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
NKX6-3Homeobox domain-containing protein. (265 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
SOX5SRY-box transcription factor 5. (763 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
G3RKF1_GORGOVon Willebrand factor A domain containing 5B1. (1149 aa)
GBX1Homeobox domain-containing protein. (309 aa)
NKX2-5NK2 homeobox 5. (324 aa)
SOX9SRY-box transcription factor 9. (509 aa)
G3RNC1_GORGOMyosin light chain 10. (226 aa)
NEUROG1Neurogenin 1. (237 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
G3RPS4_GORGOUncharacterized protein. (241 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
IL6Interleukin 6. (234 aa)
TBR1T-box brain transcription factor 1. (682 aa)
GATA1GATA binding protein 1. (413 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
G3RTC0_GORGOSox C-terminal domain-containing protein. (113 aa)
G3RTH8_GORGOPOU domain protein. (259 aa)
TBX20T-box transcription factor 20. (447 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
G3RWH6_GORGOTranscription factor 3. (673 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
G3RXP9_GORGONuclear receptor subfamily 2 group F member 2. (414 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FOXA2Forkhead box A2. (457 aa)
TBX10T-box transcription factor 10. (400 aa)
GATA6GATA binding protein 6. (596 aa)
ONECUT2One cut domain family member. (395 aa)
G3RZJ6_GORGOLEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
SOX8SRY-box transcription factor 8. (446 aa)
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
IFRD1Interferon related developmental regulator 1. (451 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
SOX17HMG box domain-containing protein. (184 aa)
MYT1LMyelin transcription factor 1 like. (1186 aa)
ZNF521Zinc finger protein 521. (1311 aa)
ENSGGOP00000024523annotation not available (408 aa)
FEZF2Uncharacterized protein. (286 aa)
G3S9R1_GORGONK2 homeobox 1. (333 aa)
G3S9W2_GORGOT-box transcription factor 18. (578 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
ARXAristaless related homeobox. (560 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GAS1Growth arrest specific 1. (345 aa)
G3SEM1_GORGOCathepsin L; Belongs to the peptidase C1 family. (333 aa)
ISL2ISL LIM homeobox 2. (359 aa)
G3SIC3_GORGOUncharacterized protein. (337 aa)
RAG2Recombination activating 2. (527 aa)
KLF4Kruppel like factor 4. (479 aa)
HOXA11Homeobox A11. (315 aa)
GAP43Growth associated protein 43. (274 aa)
G3SK49_GORGOTEA domain transcription factor 4. (453 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2137 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
ENSGGOP00000031261Myocyte enhancer factor 2C. (483 aa)
CDC73Cell division cycle 73. (452 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
WT1Uncharacterized protein. (516 aa)
ENSGGOP00000033344Uncharacterized protein. (154 aa)
DMRTA2DM domain-containing protein. (506 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
EPAS1Uncharacterized protein. (574 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1248 aa)
TM2D3TM2 domain containing 3. (247 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SLAMF8SLAM family member 8. (285 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ENSGGOP00000036799Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
ENSGGOP00000037735Uncharacterized protein. (471 aa)
TBX3T-box transcription factor 3. (743 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
ENSGGOP00000041335Uncharacterized protein. (158 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
NRG1Neuregulin 1. (713 aa)
TCF7L2HMG box domain-containing protein. (296 aa)
ENSGGOP00000042355Sclerostin domain containing 1. (230 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (533 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PTCH2Patched 2. (1203 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
CDC42Cell division cycle 42. (191 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
ENSGGOP00000045127Uncharacterized protein. (280 aa)
PTCH1Patched 1. (1447 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
ENSGGOP00000047870TPR_REGION domain-containing protein. (251 aa)
IRF4Interferon regulatory factor 4. (451 aa)
DLX1Distal-less homeobox 1. (255 aa)
CTNNB1Catenin beta 1. (781 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
IHHHH_signal domain-containing protein. (113 aa)
RUNX2Runt domain-containing protein. (541 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
ENSGGOP00000050768Paired box 2. (392 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENSGGOP00000051392CTNNB1_binding domain-containing protein. (452 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (24%) [HD]