STRINGSTRING
STAT1 STAT1 TGFB1 TGFB1 KAT7 KAT7 ARNT ARNT ABCB10 ABCB10 G3S6F8_GORGO G3S6F8_GORGO G3S598_GORGO G3S598_GORGO GPR68 GPR68 KITLG KITLG SLC9B2 SLC9B2 OCSTAMP OCSTAMP JAG1 JAG1 NOTCH2 NOTCH2 PITHD1 PITHD1 IL12B IL12B CSF3 CSF3 EVI2B EVI2B G3QRE4_GORGO G3QRE4_GORGO RCOR1 RCOR1 TRAF6 TRAF6 G3QT76_GORGO G3QT76_GORGO IFNG IFNG FAXDC2 FAXDC2 G3QTD2_GORGO G3QTD2_GORGO GATA2 GATA2 IL23R IL23R ACIN1 ACIN1 CD101 CD101 NCKAP1L NCKAP1L PPARGC1B PPARGC1B IL17A IL17A MPL MPL G3R560_GORGO G3R560_GORGO TNFSF11 TNFSF11 ROR2 ROR2 IL5 IL5 G3R7S6_GORGO G3R7S6_GORGO RIPK1 RIPK1 RHEX RHEX G3RBA4_GORGO G3RBA4_GORGO IL20 IL20 G3RCP0_GORGO G3RCP0_GORGO CALCA CALCA G3RG63_GORGO G3RG63_GORGO TREM2 TREM2 KLF10 KLF10 PF4 PF4 SCIN SCIN ACVR2A ACVR2A PRKCA PRKCA CSF1 CSF1 G3RJZ9_GORGO G3RJZ9_GORGO HAX1 HAX1 HCLS1 HCLS1 NINJ1 NINJ1 GATA1 GATA1 G3RTH8_GORGO G3RTH8_GORGO G3RVS4_GORGO G3RVS4_GORGO FADD FADD THPO THPO FOS FOS INPP5D INPP5D PLA2G3 PLA2G3 ZNF16 ZNF16 IL23A IL23A POU4F2 POU4F2 DCSTAMP DCSTAMP HOXA5 HOXA5 MTURN MTURN TESC TESC ETS1 ETS1 CD4 CD4 STAT3 STAT3 FAM210B FAM210B CCR1 CCR1 NEDD9 NEDD9 ENSGGOP00000049072 ENSGGOP00000049072 INHBA INHBA ENSGGOP00000047513 ENSGGOP00000047513 ANKRD54 ANKRD54 RAB7B RAB7B ENSGGOP00000044715 ENSGGOP00000044715 BRD1 BRD1 SMAP1 SMAP1 FES FES CTNNBIP1 CTNNBIP1 ENSGGOP00000035952 ENSGGOP00000035952 ENSGGOP00000035083 ENSGGOP00000035083 ZFP36L1 ZFP36L1 RUNX1 RUNX1 TAL1 TAL1 ENSGGOP00000033484 ENSGGOP00000033484 ENSGGOP00000033404 ENSGGOP00000033404 PRMT1 PRMT1 PPP3CA PPP3CA ENSGGOP00000032627 ENSGGOP00000032627 ENSGGOP00000032619 ENSGGOP00000032619 ENSGGOP00000032065 ENSGGOP00000032065 ENSGGOP00000030744 ENSGGOP00000030744 ENSGGOP00000030528 ENSGGOP00000030528 HIF1A HIF1A LIF LIF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT1Signal transducer and activator of transcription. (777 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
G3S6F8_GORGOMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1514 aa)
G3S598_GORGOTransmembrane protein 64. (380 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (565 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH2Notch receptor 2. (2373 aa)
PITHD1PITH domain containing 1. (211 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CSF3Colony stimulating factor 3. (207 aa)
EVI2BEcotropic viral integration site 2B. (448 aa)
G3QRE4_GORGOTribbles pseudokinase 1. (372 aa)
RCOR1REST corepressor 1. (417 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (310 aa)
G3QTD2_GORGOProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa)
GATA2GATA binding protein 2. (480 aa)
IL23RInterleukin 23 receptor. (629 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1302 aa)
CD101CD101 molecule. (1021 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
PPARGC1BPPARG coactivator 1 beta. (997 aa)
IL17AInterleukin 17A. (155 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
G3R560_GORGOLymphoid enhancer binding factor 1. (399 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (910 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
G3R7S6_GORGOCD74 molecule. (296 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
G3RBA4_GORGOInterleukin 34. (216 aa)
IL20Interleukin 20. (176 aa)
G3RCP0_GORGOHSF_DOMAIN domain-containing protein. (527 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
G3RG63_GORGOISG15 ubiquitin like modifier. (165 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
KLF10Kruppel like factor 10. (479 aa)
PF4C-X-C motif chemokine. (101 aa)
SCINScinderin. (715 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
G3RJZ9_GORGORB transcriptional corepressor 1. (756 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
NINJ1Ninjurin 1. (152 aa)
GATA1GATA binding protein 1. (413 aa)
G3RTH8_GORGOPOU domain protein. (259 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
THPOThrombopoietin. (353 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1066 aa)
PLA2G3Phospholipase A2 group III. (539 aa)
ZNF16Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis (By similarity). (682 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
POU4F2POU domain protein. (407 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
HOXA5Homeobox A5. (270 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
TESCTescalcin. (214 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CD4CD4 molecule. (458 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
INHBAInhibin subunit beta A. (426 aa)
ENSGGOP00000047513Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (348 aa)
ANKRD54Ankyrin repeat domain 54. (299 aa)
RAB7BRAB7B, member RAS oncogene family. (174 aa)
ENSGGOP00000044715FCH domain-containing protein. (121 aa)
BRD1EPL1 domain-containing protein. (276 aa)
SMAP1Small ArfGAP 1. (468 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
ENSGGOP00000035952TNF receptor-associated factor. (485 aa)
ENSGGOP00000035083DUF1279 domain-containing protein. (216 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
ENSGGOP00000033484Uncharacterized protein. (184 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (374 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
ENSGGOP00000032619cAMP responsive element binding protein 1. (341 aa)
ENSGGOP00000032065Uncharacterized protein. (245 aa)
ENSGGOP00000030744Uncharacterized protein. (323 aa)
ENSGGOP00000030528Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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