(37 nodes) Platelet-derived growth factor receptor signaling pathway network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMPD3	Uncharacterized protein. (535 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	PDGFD	Platelet derived growth factor D. (370 aa)
	ARID5B	AT-rich interaction domain 5B. (1187 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (404 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	MYO1E	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (837 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	G3R2F5_GORGO	Regulator of G protein signaling 14. (523 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	TXNIP	Thioredoxin interacting protein. (391 aa)
	PDGFRL	Platelet derived growth factor receptor like. (375 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	G3RI02_GORGO	Chondroitin sulfate proteoglycan 4. (2251 aa)
	CSRNP1	Cysteine and serine rich nuclear protein 1. (591 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (568 aa)
	G3RMM0_GORGO	Plasminogen activator; Belongs to the peptidase S1 family. (560 aa)
	LOX	Lysyl oxidase. (417 aa)
	G3RRP1_GORGO	Uncharacterized protein. (270 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (550 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (657 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	ENSGGOP00000030478	Tyrosine-protein kinase. (1151 aa)
	ENSGGOP00000034163	Uncharacterized protein. (485 aa)
	ENSGGOP00000036103	Uncharacterized protein. (509 aa)
	ENSGGOP00000036381	Uncharacterized protein. (187 aa)
	ENSGGOP00000037095	Uncharacterized protein. (575 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1305 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	ENSGGOP00000052106	Uncharacterized protein. (192 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	ENSGGOP00000043386	Uncharacterized protein. (1478 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCAR1	ENSGGOP00000010326	ENSGGOP00000052326	Tyrosine-protein kinase.	BCAR1 scaffold protein, Cas family member.	0.639
ABL1	ENSGGOP00000034163	ENSGGOP00000010326	ENSGGOP00000034163	Tyrosine-protein kinase.	Uncharacterized protein.	0.423
ABL1	G3R2F5_GORGO	ENSGGOP00000010326	ENSGGOP00000009406	Tyrosine-protein kinase.	Regulator of G protein signaling 14.	0.517
ABL1	PDGFRB	ENSGGOP00000010326	ENSGGOP00000007098	Tyrosine-protein kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.401
ABL1	PTPN11	ENSGGOP00000010326	ENSGGOP00000028308	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.423
BCAR1	ABL1	ENSGGOP00000052326	ENSGGOP00000010326	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.639
BCAR1	ITGB3	ENSGGOP00000052326	ENSGGOP00000007587	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.847
BCAR1	PDGFB	ENSGGOP00000052326	ENSGGOP00000015152	BCAR1 scaffold protein, Cas family member.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.489
BCAR1	PDGFRB	ENSGGOP00000052326	ENSGGOP00000007098	BCAR1 scaffold protein, Cas family member.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.585
BCAR1	PTPN1	ENSGGOP00000052326	ENSGGOP00000006885	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein phosphatase non-receptor type.	0.852
ENSGGOP00000030478	ENSGGOP00000034163	ENSGGOP00000030478	ENSGGOP00000034163	Tyrosine-protein kinase.	Uncharacterized protein.	0.881
ENSGGOP00000030478	ENSGGOP00000036103	ENSGGOP00000030478	ENSGGOP00000036103	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	ENSGGOP00000037095	ENSGGOP00000030478	ENSGGOP00000037095	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	G3RRP1_GORGO	ENSGGOP00000030478	ENSGGOP00000018465	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	PDGFRB	ENSGGOP00000030478	ENSGGOP00000007098	Tyrosine-protein kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.482
ENSGGOP00000030478	PTPN1	ENSGGOP00000030478	ENSGGOP00000006885	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.950
ENSGGOP00000030478	PTPN11	ENSGGOP00000030478	ENSGGOP00000028308	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.881
ENSGGOP00000034163	ABL1	ENSGGOP00000034163	ENSGGOP00000010326	Uncharacterized protein.	Tyrosine-protein kinase.	0.423
ENSGGOP00000034163	ENSGGOP00000030478	ENSGGOP00000034163	ENSGGOP00000030478	Uncharacterized protein.	Tyrosine-protein kinase.	0.881
ENSGGOP00000034163	ITGB3	ENSGGOP00000034163	ENSGGOP00000007587	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.442