(33 nodes) Vascular endothelial growth factor receptor signaling pathway network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1319 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	VEGFC	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
	ENSGGOP00000049072	Protein kinase domain-containing protein. (296 aa)
	ENSGGOP00000045477	Non-specific serine/threonine protein kinase. (530 aa)
	ENSGGOP00000040139	Uncharacterized protein. (86 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (883 aa)
	MAPKAPK2	Protein kinase domain-containing protein. (374 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	DAB2IP	DAB2 interacting protein. (1155 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
	PGF	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
	G3RF44_GORGO	Forkhead box C2. (442 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	CLEC14A	C-type lectin domain containing 14A. (490 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (788 aa)
	VEGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
	FOXC1	Fork-head domain-containing protein. (210 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1302 aa)
	FYN	Tyrosine-protein kinase. (537 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	FLT4	ENSGGOP00000052326	ENSGGOP00000006615	BCAR1 scaffold protein, Cas family member.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.487
BCAR1	FYN	ENSGGOP00000052326	ENSGGOP00000007888	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.949
BCAR1	KDR	ENSGGOP00000052326	ENSGGOP00000012526	BCAR1 scaffold protein, Cas family member.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.408
BCAR1	PTK2	ENSGGOP00000052326	ENSGGOP00000021868	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.999
BCAR1	PTK2B	ENSGGOP00000052326	ENSGGOP00000015209	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.994
BCAR1	SRC	ENSGGOP00000052326	ENSGGOP00000018321	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.999
BCAR1	VAV1	ENSGGOP00000052326	ENSGGOP00000011974	BCAR1 scaffold protein, Cas family member.	Vav guanine nucleotide exchange factor 1.	0.436
CLEC14A	FLT4	ENSGGOP00000012149	ENSGGOP00000006615	C-type lectin domain containing 14A.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.475
CLEC14A	KDR	ENSGGOP00000012149	ENSGGOP00000012526	C-type lectin domain containing 14A.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.581
ENSGGOP00000040139	ENSGGOP00000049072	ENSGGOP00000040139	ENSGGOP00000049072	Uncharacterized protein.	Protein kinase domain-containing protein.	0.434
ENSGGOP00000040139	MAPKAPK2	ENSGGOP00000040139	ENSGGOP00000038885	Uncharacterized protein.	Protein kinase domain-containing protein.	0.402
ENSGGOP00000040139	MAPKAPK3	ENSGGOP00000040139	ENSGGOP00000014578	Uncharacterized protein.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.426
ENSGGOP00000040139	VAV1	ENSGGOP00000040139	ENSGGOP00000011974	Uncharacterized protein.	Vav guanine nucleotide exchange factor 1.	0.479
ENSGGOP00000045477	ENSGGOP00000049072	ENSGGOP00000045477	ENSGGOP00000049072	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein.	0.434
ENSGGOP00000045477	MAPKAPK2	ENSGGOP00000045477	ENSGGOP00000038885	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein.	0.457
ENSGGOP00000045477	MAPKAPK3	ENSGGOP00000045477	ENSGGOP00000014578	Non-specific serine/threonine protein kinase.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.472
ENSGGOP00000045477	VAV1	ENSGGOP00000045477	ENSGGOP00000011974	Non-specific serine/threonine protein kinase.	Vav guanine nucleotide exchange factor 1.	0.479
ENSGGOP00000049072	ENSGGOP00000040139	ENSGGOP00000049072	ENSGGOP00000040139	Protein kinase domain-containing protein.	Uncharacterized protein.	0.434
ENSGGOP00000049072	ENSGGOP00000045477	ENSGGOP00000049072	ENSGGOP00000045477	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase.	0.434
ENSGGOP00000049072	FYN	ENSGGOP00000049072	ENSGGOP00000007888	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.600