(51 nodes) Ephrin receptor signaling pathway network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B. (1248 aa)
	YES1	Tyrosine-protein kinase. (558 aa)
	CHN1	Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	EPHA6	EPH receptor A6. (1131 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (803 aa)
	ENSGGOP00000034163	Uncharacterized protein. (485 aa)
	ENSGGOP00000036103	Uncharacterized protein. (509 aa)
	ENSGGOP00000037095	Uncharacterized protein. (575 aa)
	EPHB3	EPH receptor B3. (997 aa)
	SS18	SS18 subunit of BAF chromatin remodeling complex. (418 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	RASA1	RAS p21 protein activator 1. (1047 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	ENSGGOP00000046477	Uncharacterized protein. (433 aa)
	MMP2	Matrix metallopeptidase 2. (610 aa)
	GIT1	GIT ArfGAP 1. (770 aa)
	G3R1K1_GORGO	Ephrin A1; Belongs to the ephrin family. (205 aa)
	EFNB1	Ephrin B1; Belongs to the ephrin family. (346 aa)
	EPHA8	EPH receptor A8. (1005 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	MMP9	Matrix metallopeptidase 9. (707 aa)
	SIPA1L1	Signal induced proliferation associated 1 like 1. (1804 aa)
	G3RDG8_GORGO	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (233 aa)
	EPHB1	EPH receptor B1. (984 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1591 aa)
	EPHA4	EPH receptor A4. (986 aa)
	EPHA3	EPH receptor A3. (983 aa)
	EPHB4	EPH receptor B4. (987 aa)
	EPHB6	EPH receptor B6. (1019 aa)
	ARHGEF28	Rho guanine nucleotide exchange factor 28. (1700 aa)
	EPHA5	EPH receptor A5. (1038 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (336 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	G3RRP1_GORGO	Uncharacterized protein. (270 aa)
	EPHA1	EPH receptor A1. (976 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (228 aa)
	EFNA2	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (241 aa)
	PAK1	Non-specific serine/threonine protein kinase. (554 aa)
	G3QQQ6_GORGO	Ephrin B3; Belongs to the ephrin family. (340 aa)
	EPHA7	EPH receptor A7. (998 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
	EPHA10	EPH receptor A10. (897 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (709 aa)
	EPHA2	EPH receptor A2. (876 aa)
	ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A. (1138 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	EPHB2	EPH receptor B2. (1113 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKS1B	EPHA1	ENSGGOP00000008230	ENSGGOP00000000082	Ankyrin repeat and sterile alpha motif domain containing 1B.	EPH receptor A1.	0.437
ARHGEF28	ARHGEF7	ENSGGOP00000015578	ENSGGOP00000029805	Rho guanine nucleotide exchange factor 28.	Rho guanine nucleotide exchange factor 7.	0.421
ARHGEF28	PTK2	ENSGGOP00000015578	ENSGGOP00000021868	Rho guanine nucleotide exchange factor 28.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.957
ARHGEF7	ARHGEF28	ENSGGOP00000029805	ENSGGOP00000015578	Rho guanine nucleotide exchange factor 7.	Rho guanine nucleotide exchange factor 28.	0.421
ARHGEF7	EFNB1	ENSGGOP00000029805	ENSGGOP00000009730	Rho guanine nucleotide exchange factor 7.	Ephrin B1; Belongs to the ephrin family.	0.436
ARHGEF7	EFNB2	ENSGGOP00000029805	ENSGGOP00000016779	Rho guanine nucleotide exchange factor 7.	Ephrin B2; Belongs to the ephrin family.	0.436
ARHGEF7	FYN	ENSGGOP00000029805	ENSGGOP00000007888	Rho guanine nucleotide exchange factor 7.	Tyrosine-protein kinase.	0.426
ARHGEF7	G3QQQ6_GORGO	ENSGGOP00000029805	ENSGGOP00000004929	Rho guanine nucleotide exchange factor 7.	Ephrin B3; Belongs to the ephrin family.	0.436
ARHGEF7	GIT1	ENSGGOP00000029805	ENSGGOP00000049503	Rho guanine nucleotide exchange factor 7.	GIT ArfGAP 1.	0.999
ARHGEF7	NCK1	ENSGGOP00000029805	ENSGGOP00000025725	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.657
ARHGEF7	NCK2	ENSGGOP00000029805	ENSGGOP00000029741	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.836
ARHGEF7	PAK1	ENSGGOP00000029805	ENSGGOP00000003101	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.993
ARHGEF7	PTK2	ENSGGOP00000029805	ENSGGOP00000021868	Rho guanine nucleotide exchange factor 7.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.434
ARHGEF7	SRC	ENSGGOP00000029805	ENSGGOP00000018321	Rho guanine nucleotide exchange factor 7.	Tyrosine-protein kinase.	0.976
ARHGEF7	YES1	ENSGGOP00000029805	ENSGGOP00000024442	Rho guanine nucleotide exchange factor 7.	Tyrosine-protein kinase.	0.440
CHN1	EPHA4	ENSGGOP00000025465	ENSGGOP00000014427	Chimaerin; GTPase-activating protein for p21-rac.	EPH receptor A4.	0.613
CHN1	NCK1	ENSGGOP00000025465	ENSGGOP00000025725	Chimaerin; GTPase-activating protein for p21-rac.	Cytoplasmic protein.	0.412
CHN1	NCK2	ENSGGOP00000025465	ENSGGOP00000029741	Chimaerin; GTPase-activating protein for p21-rac.	Cytoplasmic protein.	0.794
CHN1	RASA1	ENSGGOP00000025465	ENSGGOP00000040915	Chimaerin; GTPase-activating protein for p21-rac.	RAS p21 protein activator 1.	0.562
CRK	ENSGGOP00000034163	ENSGGOP00000006608	ENSGGOP00000034163	CRK proto-oncogene, adaptor protein.	Uncharacterized protein.	0.405