(94 nodes) Oogenesis network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLD6	Phospholipase D family member 6. (219 aa)
	CCDC36	Coiled-coil domain containing 36. (595 aa)
	BHMG1	Basic helix-loop-helix and HMG-box containing 1. (642 aa)
	PTN	Pleiotrophin. (172 aa)
	TDRKH	Tudor and KH domain containing. (605 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (385 aa)
	HORMAD1	HORMA domain containing 1. (394 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ENSGGOP00000048909	Uncharacterized protein. (81 aa)
	IHH	HH_signal domain-containing protein. (113 aa)
	ZFY	Zinc finger Y-chromosomal protein; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity). (841 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1267 aa)
	PAQR8	Progestin and adipoQ receptor family member 8. (354 aa)
	ZNF830	Zinc finger protein 830. (372 aa)
	ENSGGOP00000041090	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (243 aa)
	WASHC5	Uncharacterized protein. (206 aa)
	SEBOX	SEBOX homeobox. (184 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	ENSGGOP00000036812	HORMA domain-containing protein. (363 aa)
	G3R5R3_GORGO	Uncharacterized protein. (363 aa)
	TDRD10	Tudor domain containing 10. (366 aa)
	YBX2	Y-box binding protein 2. (374 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	PAQR7	Progestin and adipoQ receptor family member 7. (348 aa)
	ENSGGOP00000031992	Uncharacterized protein. (76 aa)
	FOXL2	Forkhead box L2. (364 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (596 aa)
	BRCA2	BRCA2 DNA repair associated. (3416 aa)
	TUT7	Terminal uridylyl transferase 7. (1494 aa)
	TDRD5	Tudor domain containing 5. (1035 aa)
	ASPM	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
	NANOS3	Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (198 aa)
	TDRD15	Tudor domain containing 15. (1934 aa)
	YTHDC1	YTH domain containing 1. (736 aa)
	MDK	Midkine. (143 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (373 aa)
	AMH	Anti-Mullerian hormone. (560 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)
	NOBOX	NOBOX oogenesis homeobox. (690 aa)
	MTHFSD	Methenyltetrahydrofolate synthetase domain containing. (383 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	G3QFD4_GORGO	Formin 2. (1532 aa)
	FBXO5	F-box protein 5. (447 aa)
	GPR149	G protein-coupled receptor 149. (731 aa)
	G3QI94_GORGO	BHLH domain-containing protein. (425 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	G3QK53_GORGO	Diaphanous related formin 2. (1100 aa)
	LGR5	LRRNT domain-containing protein. (363 aa)
	EREG	EGF-like domain-containing protein. (222 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (219 aa)
	PAQR5	Progestin and adipoQ receptor family member 5. (330 aa)
	TAF4B	TATA-box binding protein associated factor 4b. (862 aa)
	TDRD1	Tudor domain containing 1. (1189 aa)
	PABPC1L	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
	WDR77	WD repeat domain 77. (342 aa)
	G3QRS4_GORGO	ZP domain-containing protein. (290 aa)
	PANX-2	Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	ZGLP1	Zinc finger GATA like protein 1. (271 aa)
	NPM2	Nucleophosmin/nucleoplasmin 2. (214 aa)
	SOHLH1	Spermatogenesis and oogenesis specific basic helix-loop-helix 1. (387 aa)
	KMT2D	Lysine methyltransferase 2D. (5546 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
	G3QZ33_GORGO	Uncharacterized protein; Belongs to the AAA ATPase family. (362 aa)
	PIWIL2	Uncharacterized protein; Belongs to the argonaute family. (623 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1742 aa)
	HEXB	Beta-hexosaminidase. (519 aa)
	TUT4	Uncharacterized protein. (340 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
	C14H14orf39	Chromosome 14 open reading frame 39. (587 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	G3RPA0_GORGO	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (204 aa)
	MLH1	MutL homolog 1. (756 aa)
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	REC8	REC8 meiotic recombination protein. (547 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	DDX20	DEAD-box helicase 20. (824 aa)
	PTX3	Pentraxin 3. (381 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	TDRD7	Tudor domain containing 7. (1098 aa)
	PDE3A	Phosphodiesterase. (979 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	EDN1	Endothelin 1. (212 aa)
	TDRD6	Tudor domain containing 6. (2096 aa)
	STRA8	Stimulated by retinoic acid 8. (330 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (952 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	CDC25B	Cell division cycle 25B. (580 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	BMPR1B	ENSGGOP00000021688	ENSGGOP00000011797	Anti-Mullerian hormone.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.801
AMH	FOXL2	ENSGGOP00000021688	ENSGGOP00000029473	Anti-Mullerian hormone.	Forkhead box L2.	0.486
AMH	WNT4	ENSGGOP00000021688	ENSGGOP00000047347	Anti-Mullerian hormone.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.433
ASPM	AURKC	ENSGGOP00000024559	ENSGGOP00000007820	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Aurora kinase C; Belongs to the protein kinase superfamily.	0.647
ASPM	FBXO5	ENSGGOP00000024559	ENSGGOP00000001583	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	F-box protein 5.	0.426
ASPM	G3QZ33_GORGO	ENSGGOP00000024559	ENSGGOP00000008132	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Uncharacterized protein; Belongs to the AAA ATPase family.	0.578
ATM	BCL2	ENSGGOP00000010144	ENSGGOP00000000778	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.517
ATM	BRCA2	ENSGGOP00000010144	ENSGGOP00000027226	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.978
ATM	CTNNB1	ENSGGOP00000010144	ENSGGOP00000048898	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta 1.	0.487
ATM	DMC1	ENSGGOP00000010144	ENSGGOP00000010934	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.905
ATM	ERCC1	ENSGGOP00000010144	ENSGGOP00000036857	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.773
ATM	MLH1	ENSGGOP00000010144	ENSGGOP00000015949	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1.	0.935
ATM	SPO11	ENSGGOP00000010144	ENSGGOP00000008652	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SPO11 initiator of meiotic double stranded breaks.	0.651
ATM	SRC	ENSGGOP00000010144	ENSGGOP00000018321	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.500
AURKC	ASPM	ENSGGOP00000007820	ENSGGOP00000024559	Aurora kinase C; Belongs to the protein kinase superfamily.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.647
AURKC	G3QZ33_GORGO	ENSGGOP00000007820	ENSGGOP00000008132	Aurora kinase C; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.472
BCL2	ATM	ENSGGOP00000000778	ENSGGOP00000010144	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.517
BCL2	CTNNB1	ENSGGOP00000000778	ENSGGOP00000048898	BCL2 apoptosis regulator.	Catenin beta 1.	0.597
BCL2	RPS6KA2	ENSGGOP00000000778	ENSGGOP00000034062	BCL2 apoptosis regulator.	Ribosomal protein S6 kinase.	0.468
BCL2	SRC	ENSGGOP00000000778	ENSGGOP00000018321	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.688