(46 nodes) Autonomic nervous system development network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PHOX2B	Paired like homeobox 2B. (314 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	SOX11	Transcription factor SOX. (441 aa)
	ADARB1	Adenosine deaminase RNA specific B1. (741 aa)
	PLXNA3	Plexin A3. (1871 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	FN1	Fibronectin 1. (2477 aa)
	PRLH	Prolactin releasing hormone. (87 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (771 aa)
	RHOXF1	Rhox homeobox family member 1. (184 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SOX10	HMG box domain-containing protein. (286 aa)
	KIF26A	Kinesin family member 26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1882 aa)
	SOX8	SRY-box transcription factor 8. (446 aa)
	PHOX2A	Paired like homeobox 2A. (255 aa)
	ARX	Aristaless related homeobox. (560 aa)
	PHACTR4	Phosphatase and actin regulator. (712 aa)
	ISX	Intestine specific homeobox. (245 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (785 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PLXNA4	Plexin A4. (1854 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	TBX1	Uncharacterized protein. (311 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	NF1	Neurofibromin 1. (2811 aa)
	HOXB1	Homeobox B1. (307 aa)
	HOXB2	Homeobox B2. (356 aa)
	SOX4	Transcription factor SOX. (444 aa)
	NAV2	Neuron navigator 2. (2485 aa)
	TLX2	T cell leukemia homeobox 2. (284 aa)
	GATA3	GATA binding protein 3. (444 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (198 aa)
	GBX2	Gastrulation brain homeobox 2. (303 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	EGR2	Early growth response 2. (476 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	HLX	H2.0 like homeobox. (495 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARX	TLX2	ENSGGOP00000025491	ENSGGOP00000006163	Aristaless related homeobox.	T cell leukemia homeobox 2.	0.471
ASCL1	GATA3	ENSGGOP00000005366	ENSGGOP00000006027	Achaete-scute family bHLH transcription factor 1.	GATA binding protein 3.	0.408
ASCL1	HES1	ENSGGOP00000005366	ENSGGOP00000008330	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.595
ASCL1	HOXB2	ENSGGOP00000005366	ENSGGOP00000009680	Achaete-scute family bHLH transcription factor 1.	Homeobox B2.	0.488
ASCL1	PHOX2A	ENSGGOP00000005366	ENSGGOP00000021999	Achaete-scute family bHLH transcription factor 1.	Paired like homeobox 2A.	0.691
ASCL1	PHOX2B	ENSGGOP00000005366	ENSGGOP00000006092	Achaete-scute family bHLH transcription factor 1.	Paired like homeobox 2B.	0.679
ASCL1	RET	ENSGGOP00000005366	ENSGGOP00000003517	Achaete-scute family bHLH transcription factor 1.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.451
ASCL1	SOX10	ENSGGOP00000005366	ENSGGOP00000019256	Achaete-scute family bHLH transcription factor 1.	HMG box domain-containing protein.	0.448
ASCL1	SOX4	ENSGGOP00000005366	ENSGGOP00000012018	Achaete-scute family bHLH transcription factor 1.	Transcription factor SOX.	0.447
CTNNB1	FZD3	ENSGGOP00000048898	ENSGGOP00000017505	Catenin beta 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.633
CTNNB1	NF1	ENSGGOP00000048898	ENSGGOP00000006859	Catenin beta 1.	Neurofibromin 1.	0.407
CTNNB1	NTRK1	ENSGGOP00000048898	ENSGGOP00000040180	Catenin beta 1.	Tyrosine-protein kinase receptor.	0.608
CTNNB1	RET	ENSGGOP00000048898	ENSGGOP00000003517	Catenin beta 1.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.504
CTNNB1	SOX10	ENSGGOP00000048898	ENSGGOP00000019256	Catenin beta 1.	HMG box domain-containing protein.	0.621
CTNNB1	SOX11	ENSGGOP00000048898	ENSGGOP00000051724	Catenin beta 1.	Transcription factor SOX.	0.578
CTNNB1	SOX4	ENSGGOP00000048898	ENSGGOP00000012018	Catenin beta 1.	Transcription factor SOX.	0.756
CTNNB1	SOX8	ENSGGOP00000048898	ENSGGOP00000021723	Catenin beta 1.	SRY-box transcription factor 8.	0.548
CTNNB1	TFAP2A	ENSGGOP00000048898	ENSGGOP00000007379	Catenin beta 1.	Transcription factor AP-2 alpha.	0.487
EDNRA	EDNRB	ENSGGOP00000000610	ENSGGOP00000014067	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.982
EDNRB	EDNRA	ENSGGOP00000014067	ENSGGOP00000000610	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.982