(20 nodes) Sympathetic nervous system development network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (198 aa)
	GATA3	GATA binding protein 3. (444 aa)
	PHOX2B	Paired like homeobox 2B. (314 aa)
	NF1	Neurofibromin 1. (2811 aa)
	PLXNA4	Plexin A4. (1854 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	SOX4	Transcription factor SOX. (444 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (771 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	PHOX2A	Paired like homeobox 2A. (255 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (785 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	SOX11	Transcription factor SOX. (441 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	GATA3	ENSGGOP00000005366	ENSGGOP00000006027	Achaete-scute family bHLH transcription factor 1.	GATA binding protein 3.	0.408
ASCL1	PHOX2A	ENSGGOP00000005366	ENSGGOP00000021999	Achaete-scute family bHLH transcription factor 1.	Paired like homeobox 2A.	0.691
ASCL1	PHOX2B	ENSGGOP00000005366	ENSGGOP00000006092	Achaete-scute family bHLH transcription factor 1.	Paired like homeobox 2B.	0.679
ASCL1	SOX4	ENSGGOP00000005366	ENSGGOP00000012018	Achaete-scute family bHLH transcription factor 1.	Transcription factor SOX.	0.447
CTNNB1	FZD3	ENSGGOP00000048898	ENSGGOP00000017505	Catenin beta 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.633
CTNNB1	NF1	ENSGGOP00000048898	ENSGGOP00000006859	Catenin beta 1.	Neurofibromin 1.	0.407
CTNNB1	NTRK1	ENSGGOP00000048898	ENSGGOP00000040180	Catenin beta 1.	Tyrosine-protein kinase receptor.	0.608
CTNNB1	SOX11	ENSGGOP00000048898	ENSGGOP00000051724	Catenin beta 1.	Transcription factor SOX.	0.578
CTNNB1	SOX4	ENSGGOP00000048898	ENSGGOP00000012018	Catenin beta 1.	Transcription factor SOX.	0.756
FZD3	CTNNB1	ENSGGOP00000017505	ENSGGOP00000048898	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta 1.	0.633
FZD3	NTRK1	ENSGGOP00000017505	ENSGGOP00000040180	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Tyrosine-protein kinase receptor.	0.557
GATA3	ASCL1	ENSGGOP00000006027	ENSGGOP00000005366	GATA binding protein 3.	Achaete-scute family bHLH transcription factor 1.	0.408
GATA3	HAND2	ENSGGOP00000006027	ENSGGOP00000006012	GATA binding protein 3.	Heart and neural crest derivatives expressed 2.	0.571
GATA3	PHOX2B	ENSGGOP00000006027	ENSGGOP00000006092	GATA binding protein 3.	Paired like homeobox 2B.	0.524
GATA3	SOX4	ENSGGOP00000006027	ENSGGOP00000012018	GATA binding protein 3.	Transcription factor SOX.	0.542
GDNF	NTRK1	ENSGGOP00000049478	ENSGGOP00000040180	Glial cell derived neurotrophic factor.	Tyrosine-protein kinase receptor.	0.439
HAND2	GATA3	ENSGGOP00000006012	ENSGGOP00000006027	Heart and neural crest derivatives expressed 2.	GATA binding protein 3.	0.571
HAND2	PHOX2A	ENSGGOP00000006012	ENSGGOP00000021999	Heart and neural crest derivatives expressed 2.	Paired like homeobox 2A.	0.556
HAND2	PHOX2B	ENSGGOP00000006012	ENSGGOP00000006092	Heart and neural crest derivatives expressed 2.	Paired like homeobox 2B.	0.612
NF1	CTNNB1	ENSGGOP00000006859	ENSGGOP00000048898	Neurofibromin 1.	Catenin beta 1.	0.407