STRINGSTRING
IGF1 IGF1 HBEGF HBEGF CX3CL1 CX3CL1 G3QER9_GORGO G3QER9_GORGO IL6R IL6R ITGA2 ITGA2 PDGFD PDGFD NOTCH3 NOTCH3 TERT TERT BMPR1A BMPR1A EREG EREG CALCRL CALCRL THBS1 THBS1 ENSGGOP00000046735 ENSGGOP00000046735 MMP2 MMP2 HMOX1 HMOX1 ENSGGOP00000044168 ENSGGOP00000044168 SMPD3 SMPD3 ENSGGOP00000043090 ENSGGOP00000043090 ENSGGOP00000042614 ENSGGOP00000042614 ENSGGOP00000041058 ENSGGOP00000041058 CCN4 CCN4 XBP1 XBP1 ENSGGOP00000032627 ENSGGOP00000032627 ENSGGOP00000030478 ENSGGOP00000030478 FRS2 FRS2 S1PR1 S1PR1 MEF2D MEF2D STAT1 STAT1 TGFB1 TGFB1 GNAI3 GNAI3 ENSGGOP00000024523 ENSGGOP00000024523 SERPINF2 SERPINF2 G3S6B7_GORGO G3S6B7_GORGO MAP3K5 MAP3K5 G3S132_GORGO G3S132_GORGO IGFBP5 IGFBP5 IRAK4 IRAK4 PHB PHB FOXJ2 FOXJ2 HTR1B HTR1B NR4A3 NR4A3 RPS6KB1 RPS6KB1 CDH13 CDH13 IL6 IL6 SRC SRC IRAK1 IRAK1 G3RR23_GORGO G3RR23_GORGO PTGS2 PTGS2 TGFBR2 TGFBR2 DNMT1 DNMT1 IL18 IL18 PDGFB PDGFB BMP4 BMP4 PTAFR PTAFR MMP9 MMP9 EDN1 EDN1 IGF1R IGF1R G3R8K9_GORGO G3R8K9_GORGO HDAC1 HDAC1 DDR2 DDR2 G3R4Q6_GORGO G3R4Q6_GORGO G3R4E1_GORGO G3R4E1_GORGO G3R439_GORGO G3R439_GORGO HPGD HPGD ALOX12 ALOX12 G3R2M9_GORGO G3R2M9_GORGO PIK3CA PIK3CA MNAT1 MNAT1 G3QZ51_GORGO G3QZ51_GORGO LDLRAP1 LDLRAP1 ITGB3 ITGB3 G3QXA0_GORGO G3QXA0_GORGO ADAMTS1 ADAMTS1 PDGFRB PDGFRB GNAI2 GNAI2 NF1 NF1 NOX1 NOX1 ERN1 ERN1 G3QT76_GORGO G3QT76_GORGO G3QR91_GORGO G3QR91_GORGO FGF9 FGF9 NPY5R NPY5R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF1IlGF domain-containing protein. (196 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
G3QER9_GORGOElastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
IL6RInterleukin 6 receptor. (468 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
NOTCH3Notch receptor 3. (2317 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EREGEGF-like domain-containing protein. (222 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
MMP2Matrix metallopeptidase 2. (610 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
ENSGGOP00000044168Prohibitin. (258 aa)
SMPD3Uncharacterized protein. (535 aa)
ENSGGOP00000043090Prohibitin. (177 aa)
ENSGGOP00000042614Zinc finger protein 143. (620 aa)
ENSGGOP00000041058annotation not available (54 aa)
CCN4Cellular communication network factor 4. (368 aa)
XBP1BZIP domain-containing protein. (380 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ENSGGOP00000024523annotation not available (408 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
G3S6B7_GORGOPyrimidinergic receptor P2Y6. (328 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
G3S132_GORGOProhibitin. (230 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PHBProhibitin. (272 aa)
FOXJ2Fork-head domain-containing protein. (461 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (390 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (550 aa)
RPS6KB1Protein kinase domain-containing protein. (210 aa)
CDH13Cadherin 13. (760 aa)
IL6Interleukin 6. (234 aa)
SRCTyrosine-protein kinase. (542 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
G3RR23_GORGOUncharacterized protein. (210 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1658 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
EDN1Endothelin 1. (212 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
G3R8K9_GORGOAllograft inflammatory factor 1. (147 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
G3R4Q6_GORGOUncharacterized protein. (431 aa)
G3R4E1_GORGOForkhead box P1. (693 aa)
G3R439_GORGOHes family bHLH transcription factor 5. (165 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
G3R2M9_GORGOProhibitin. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
G3QZ51_GORGOFibroblast growth factor receptor. (822 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (837 aa)
G3QXA0_GORGOSCY domain-containing protein. (53 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
GNAI2G protein subunit alpha i2. (355 aa)
NF1Neurofibromin 1. (2811 aa)
NOX1NADPH oxidase 1. (564 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G3QR91_GORGOMitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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