(46 nodes) Embryonic cranial skeleton morphogenesis network (Gorilla gorilla)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALX3	ALX homeobox 3. (343 aa)
	SIX4	SIX homeobox 4. (677 aa)
	TBX1	Uncharacterized protein. (311 aa)
	SIX2	SIX homeobox 2. (291 aa)
	G3QZ51_GORGO	Fibroblast growth factor receptor. (822 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	IFT140	Intraflagellar transport 140. (1462 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)
	PAX5	Paired box 5. (396 aa)
	LHX1	LIM homeobox 1. (406 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	HOXA2	Homeobox A2. (375 aa)
	HOXA1	Homeobox A1. (335 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SIX1	Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] (284 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	RUNX2	Runt domain-containing protein. (541 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (420 aa)
	ENSGGOP00000045423	Homeobox domain-containing protein. (228 aa)
	SMAD3	Mothers against decapentaplegic homolog. (356 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
	SLC39A1	Solute carrier family 39 member 1. (324 aa)
	ENSGGOP00000032065	Uncharacterized protein. (245 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	MED12	Mediator complex subunit 12. (2177 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	ENSGGOP00000024523	annotation not available (408 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (993 aa)
	TULP3	TUB like protein 3; Belongs to the TUB family. (501 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	G3RKX7_GORGO	Carbohydrate sulfotransferase. (352 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	G3RF44_GORGO	Forkhead box C2. (442 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	PRRX1	Paired related homeobox 1. (245 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	TBX15	ENSGGOP00000003988	ENSGGOP00000013139	ALX homeobox 3.	T-box transcription factor 15.	0.574
BMP4	DLX2	ENSGGOP00000014564	ENSGGOP00000005192	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.461
BMP4	FGF8	ENSGGOP00000014564	ENSGGOP00000014743	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP4	G3QZ51_GORGO	ENSGGOP00000014564	ENSGGOP00000008150	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.473
BMP4	RUNX2	ENSGGOP00000014564	ENSGGOP00000049836	Bone morphogenetic protein 4.	Runt domain-containing protein.	0.709
BMP4	SMAD2	ENSGGOP00000014564	ENSGGOP00000004612	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.673
BMP4	SMAD3	ENSGGOP00000014564	ENSGGOP00000045294	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.591
BMP4	TGFBR1	ENSGGOP00000014564	ENSGGOP00000051200	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.722
BMP4	TGFBR2	ENSGGOP00000014564	ENSGGOP00000016505	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.466
DLX2	BMP4	ENSGGOP00000005192	ENSGGOP00000014564	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.461
DLX2	ENSGGOP00000024523	ENSGGOP00000005192	ENSGGOP00000024523	Distal-less homeobox 2.	annotation not available	0.461
DLX2	FGF8	ENSGGOP00000005192	ENSGGOP00000014743	Distal-less homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.483
DLX2	HOXA2	ENSGGOP00000005192	ENSGGOP00000002177	Distal-less homeobox 2.	Homeobox A2.	0.453
DLX2	PAX5	ENSGGOP00000005192	ENSGGOP00000003571	Distal-less homeobox 2.	Paired box 5.	0.542
ENSGGOP00000024523	DLX2	ENSGGOP00000024523	ENSGGOP00000005192	annotation not available	Distal-less homeobox 2.	0.461
ENSGGOP00000024523	FGF8	ENSGGOP00000024523	ENSGGOP00000014743	annotation not available	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
ENSGGOP00000024523	G3QZ51_GORGO	ENSGGOP00000024523	ENSGGOP00000008150	annotation not available	Fibroblast growth factor receptor.	0.473
ENSGGOP00000024523	RUNX2	ENSGGOP00000024523	ENSGGOP00000049836	annotation not available	Runt domain-containing protein.	0.624
ENSGGOP00000024523	SMAD2	ENSGGOP00000024523	ENSGGOP00000004612	annotation not available	Mothers against decapentaplegic homolog.	0.673
ENSGGOP00000024523	SMAD3	ENSGGOP00000024523	ENSGGOP00000045294	annotation not available	Mothers against decapentaplegic homolog.	0.591