STRINGSTRING
LYN LYN TPPP TPPP EIF2B2 EIF2B2 PTEN PTEN DUSP10 DUSP10 GLI3 GLI3 CNTNAP1 CNTNAP1 B4GALT6 B4GALT6 NEUROD4 NEUROD4 ERBB2 ERBB2 GPR17 GPR17 ASPA ASPA DLX2 DLX2 ASCL1 ASCL1 MAL MAL NF1 NF1 TRPC4 TRPC4 EIF2B5 EIF2B5 PRDM8 PRDM8 HDAC11 HDAC11 NKX2-2 NKX2-2 NKX6-1 NKX6-1 EIF2B1 EIF2B1 NOTCH1 NOTCH1 TSPAN2 TSPAN2 PAX6 PAX6 G3R439_GORGO G3R439_GORGO SUZ12 SUZ12 MTOR MTOR SOX6 SOX6 EIF2B4 EIF2B4 CSK CSK G3R7P4_GORGO G3R7P4_GORGO NSUN5-2 NSUN5-2 HDAC1 HDAC1 ACY3 ACY3 EIF2B3 EIF2B3 WASF3 WASF3 MYRF MYRF SOX13 SOX13 G3RCH2_GORGO G3RCH2_GORGO SHH SHH NTRK2 NTRK2 BNIP3 BNIP3 RHEB RHEB CNTN2 CNTN2 NSUN5 NSUN5 PLP1 PLP1 CLU CLU CDKN2C CDKN2C SOX9 SOX9 G3RNB7_GORGO G3RNB7_GORGO SOX10 SOX10 SOX8 SOX8 LPAR1 LPAR1 KCNJ10 KCNJ10 G3S9R1_GORGO G3S9R1_GORGO TGFB1 TGFB1 PTPRZ1 PTPRZ1 MED12 MED12 CNTN1 CNTN1 B4GALT5 B4GALT5 SLC8A3 SLC8A3 NRG1 NRG1 ENSGGOP00000043662 ENSGGOP00000043662 BOK BOK CNP CNP DLX1 DLX1 MAG MAG NCSTN NCSTN ABCA2 ABCA2 CTNNB1 CTNNB1 ERCC2 ERCC2 SOX11 SOX11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LYNTyrosine-protein kinase. (512 aa)
TPPPTubulin polymerization promoting protein. (221 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DUSP10Dual specificity phosphatase 10. (399 aa)
GLI3GLI family zinc finger 3. (1580 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ASPAAspartoacylase. (313 aa)
DLX2Distal-less homeobox 2. (328 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
MALMal, T cell differentiation protein. (153 aa)
NF1Neurofibromin 1. (2811 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
PRDM8PR/SET domain 8. (684 aa)
HDAC11Histone deacetylase 11. (347 aa)
NKX2-2NK2 homeobox 2. (273 aa)
NKX6-1NK6 homeobox 1. (367 aa)
EIF2B1Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (306 aa)
NOTCH1Uncharacterized protein. (1606 aa)
TSPAN2Tetraspanin. (243 aa)
PAX6Uncharacterized protein. (475 aa)
G3R439_GORGOHes family bHLH transcription factor 5. (165 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (610 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
SOX6SRY-box transcription factor 6. (829 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (523 aa)
CSKTyrosine-protein kinase. (450 aa)
G3R7P4_GORGOTeneurin transmembrane protein 4. (2690 aa)
NSUN5-2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ACY3Aminoacylase 3. (319 aa)
EIF2B3Eukaryotic translation initiation factor 2B subunit gamma. (402 aa)
WASF3WASP family member 3. (502 aa)
MYRFMyelin regulatory factor. (1151 aa)
SOX13SRY-box transcription factor 13. (622 aa)
G3RCH2_GORGOFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (336 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
NTRK2Tyrosine-protein kinase receptor. (767 aa)
BNIP3Uncharacterized protein. (194 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
CNTN2Contactin 2. (1040 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (468 aa)
PLP1Proteolipid protein 1. (277 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SOX9SRY-box transcription factor 9. (509 aa)
G3RNB7_GORGOUncharacterized protein. (661 aa)
SOX10HMG box domain-containing protein. (286 aa)
SOX8SRY-box transcription factor 8. (446 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
KCNJ10Uncharacterized protein. (379 aa)
G3S9R1_GORGONK2 homeobox 1. (333 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2316 aa)
MED12Mediator complex subunit 12. (2177 aa)
CNTN1Contactin 1. (1028 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (349 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
NRG1Neuregulin 1. (713 aa)
ENSGGOP00000043662Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
DLX1Distal-less homeobox 1. (255 aa)
MAGMyelin associated glycoprotein. (626 aa)
NCSTNNicastrin. (721 aa)
ABCA2ATP binding cassette subfamily A member 2. (2459 aa)
CTNNB1Catenin beta 1. (781 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (810 aa)
SOX11Transcription factor SOX. (441 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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