(30 nodes) Regulation of astrocyte differentiation network (Gorilla gorilla)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TTBK1	Tau tubulin kinase 1. (1322 aa)
	MAG	Myelin associated glycoprotein. (626 aa)
	ENSGGOP00000048403	Lep_receptor_Ig domain-containing protein. (92 aa)
	LDLR	Low density lipoprotein receptor. (859 aa)
	ENSGGOP00000035693	Pre-mRNA processing factor 19. (524 aa)
	ENSGGOP00000032627	Uncharacterized protein. (118 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	G3SIC3_GORGO	Uncharacterized protein. (337 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	KDM4A	Uncharacterized protein. (1064 aa)
	IL6	Interleukin 6. (234 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (481 aa)
	G3RMW7_GORGO	DAB adaptor protein 1. (588 aa)
	MBD1	Methyl-CpG binding domain protein 1. (655 aa)
	G3RIZ8_GORGO	Bridging integrator 1. (593 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	CNTN2	Contactin 2. (1040 aa)
	EPHA4	EPH receptor A4. (986 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
	G3R439_GORGO	Hes family bHLH transcription factor 5. (165 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	NOTCH1	Uncharacterized protein. (1606 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	CLCF1	Uncharacterized protein. (322 aa)
	NF1	Neurofibromin 1. (2811 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	IL6ST	Fibronectin type-III domain-containing protein. (329 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	ENSGGOP00000049122	Uncharacterized protein. (305 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	IL6	ENSGGOP00000021281	ENSGGOP00000018546	Bone morphogenetic protein 2.	Interleukin 6.	0.447
BMP2	SHH	ENSGGOP00000021281	ENSGGOP00000013669	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.611
CLCF1	IL6ST	ENSGGOP00000008031	ENSGGOP00000003666	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.924
CLCF1	LIF	ENSGGOP00000008031	ENSGGOP00000028024	Uncharacterized protein.	LIF interleukin 6 family cytokine.	0.423
ENSGGOP00000048403	IL6	ENSGGOP00000048403	ENSGGOP00000018546	Lep_receptor_Ig domain-containing protein.	Interleukin 6.	0.618
ENSGGOP00000048403	LIF	ENSGGOP00000048403	ENSGGOP00000028024	Lep_receptor_Ig domain-containing protein.	LIF interleukin 6 family cytokine.	0.580
ENSGGOP00000049122	IL6	ENSGGOP00000049122	ENSGGOP00000018546	Uncharacterized protein.	Interleukin 6.	0.618
ENSGGOP00000049122	IL6ST	ENSGGOP00000049122	ENSGGOP00000003666	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.930
ENSGGOP00000049122	LIF	ENSGGOP00000049122	ENSGGOP00000028024	Uncharacterized protein.	LIF interleukin 6 family cytokine.	0.580
EPHA4	MAG	ENSGGOP00000014427	ENSGGOP00000048556	EPH receptor A4.	Myelin associated glycoprotein.	0.436
F2	IL6	ENSGGOP00000006823	ENSGGOP00000018546	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Interleukin 6.	0.513
F2	SERPINE2	ENSGGOP00000006823	ENSGGOP00000000961	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family E member 2; Belongs to the serpin family.	0.957
G3R439_GORGO	NOTCH1	ENSGGOP00000010026	ENSGGOP00000009720	Hes family bHLH transcription factor 5.	Uncharacterized protein.	0.747
G3RIZ8_GORGO	TREM2	ENSGGOP00000015667	ENSGGOP00000014711	Bridging integrator 1.	Triggering receptor expressed on myeloid cells 2.	0.524
G3RMW7_GORGO	LDLR	ENSGGOP00000017133	ENSGGOP00000038549	DAB adaptor protein 1.	Low density lipoprotein receptor.	0.745
HES1	NOTCH1	ENSGGOP00000008330	ENSGGOP00000009720	Hes family bHLH transcription factor 1.	Uncharacterized protein.	0.631
IL6	BMP2	ENSGGOP00000018546	ENSGGOP00000021281	Interleukin 6.	Bone morphogenetic protein 2.	0.447
IL6	ENSGGOP00000048403	ENSGGOP00000018546	ENSGGOP00000048403	Interleukin 6.	Lep_receptor_Ig domain-containing protein.	0.618
IL6	ENSGGOP00000049122	ENSGGOP00000018546	ENSGGOP00000049122	Interleukin 6.	Uncharacterized protein.	0.618
IL6	F2	ENSGGOP00000018546	ENSGGOP00000006823	Interleukin 6.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.513