STRINGSTRING
G3R037_GORGO G3R037_GORGO STAP1 STAP1 PTGER3 PTGER3 APP APP ENSGGOP00000049861 ENSGGOP00000049861 NUPR1 NUPR1 ENSGGOP00000046758 ENSGGOP00000046758 TNFRSF11A TNFRSF11A ENSGGOP00000046335 ENSGGOP00000046335 NLRP6 NLRP6 ENSGGOP00000045267 ENSGGOP00000045267 CEBPB CEBPB TNIP1 TNIP1 GPRC5B GPRC5B NAIP NAIP PDCD4 PDCD4 IL33 IL33 IL15 IL15 CCN4 CCN4 GPR4 GPR4 SNX4 SNX4 ENSGGOP00000038747 ENSGGOP00000038747 LDLR LDLR KARS1 KARS1 CEBPA CEBPA VAMP8 VAMP8 LRRK2 LRRK2 TSLP TSLP FCGR1A FCGR1A TAFA3 TAFA3 ENSGGOP00000032091 ENSGGOP00000032091 CD28 CD28 ENSGGOP00000030478 ENSGGOP00000030478 ENSGGOP00000030029 ENSGGOP00000030029 ENSGGOP00000029826 ENSGGOP00000029826 ENSGGOP00000029762 ENSGGOP00000029762 ENSGGOP00000029367 ENSGGOP00000029367 IDO1 IDO1 C2CD4B C2CD4B PLCG2 PLCG2 LILRA5 LILRA5 ENSGGOP00000027573 ENSGGOP00000027573 SNCA SNCA TLR3 TLR3 TNFRSF1A TNFRSF1A TTBK1 TTBK1 CX3CL1 CX3CL1 S100A9 S100A9 C2CD4C C2CD4C ITGA2 ITGA2 ADORA2B ADORA2B IL23A IL23A CTSC CTSC GPSM3 GPSM3 NLRC4 NLRC4 ETS1 ETS1 TLR2 TLR2 LGALS2 LGALS2 SUCNR1 SUCNR1 DHX9 DHX9 PLA2G7 PLA2G7 BTK BTK C3 C3 PIK3CG PIK3CG NAPEPLD NAPEPLD TLR10 TLR10 MDK MDK IL2 IL2 G3S121_GORGO G3S121_GORGO G3S0Q7_GORGO G3S0Q7_GORGO IL17RA IL17RA NFKBIZ NFKBIZ C2CD4D C2CD4D TLR7 TLR7 PLA2G3 PLA2G3 CCL3 CCL3 S100A8 S100A8 G3RVS4_GORGO G3RVS4_GORGO G3RT49_GORGO G3RT49_GORGO G3RT38_GORGO G3RT38_GORGO IL6 IL6 TNFSF4 TNFSF4 CCL1 CCL1 PTGS2 PTGS2 CCR2 CCR2 NINJ1 NINJ1 PYCARD PYCARD IL1RL1 IL1RL1 CCR7 CCR7 IL18 IL18 GRN GRN G3RID2_GORGO G3RID2_GORGO G3RI71_GORGO G3RI71_GORGO RPS19 RPS19 TREM2 TREM2 NKG7 NKG7 PDE2A PDE2A ALOX5AP ALOX5AP NMI NMI G3RAL4_GORGO G3RAL4_GORGO G3RAJ9_GORGO G3RAJ9_GORGO RIPK1 RIPK1 G3R8T5_GORGO G3R8T5_GORGO TRADD TRADD NLRP1 NLRP1 LGALS1 LGALS1 TNFSF11 TNFSF11 ZBP1 ZBP1 NFKBIA NFKBIA NLRP10 NLRP10 NLRP12 NLRP12 IFI35 IFI35 MMP8 MMP8 DDTL DDTL IL12B IL12B NPY5R NPY5R TRPV4 TRPV4 CCL24 CCL24 MGST2 MGST2 IL16 IL16 G3QRS4_GORGO G3QRS4_GORGO CLOCK CLOCK TNFSF18 TNFSF18 FFAR2 FFAR2 G3QT71_GORGO G3QT71_GORGO G3QT76_GORGO G3QT76_GORGO IFNG IFNG AIM2 AIM2 CCDC142 CCDC142 IL1B IL1B G3QUX8_GORGO G3QUX8_GORGO S100A12 S100A12 HYAL2 HYAL2 OSM OSM SERPINE1 SERPINE1 FABP4 FABP4 WNT5A WNT5A G3QX51_GORGO G3QX51_GORGO CD81 CD81 PTGER4 PTGER4 CD47 CD47 IL21 IL21 PLA2G2A PLA2G2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3R037_GORGOFem-1 homolog A. (653 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
PTGER3Prostaglandin E receptor 3. (418 aa)
APPAmyloid beta precursor protein. (771 aa)
ENSGGOP00000049861Uncharacterized protein; Belongs to the synaptobrevin family. (230 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
TNFRSF11ATNF receptor superfamily member 11a. (616 aa)
ENSGGOP00000046335Uncharacterized protein. (118 aa)
NLRP6Uncharacterized protein. (912 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
TNIP1TNFAIP3 interacting protein 1. (645 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
NAIPUncharacterized protein. (198 aa)
PDCD4Programmed cell death 4. (469 aa)
IL33Interleukin 33. (270 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CCN4Cellular communication network factor 4. (368 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SNX4Sorting nexin 4. (450 aa)
ENSGGOP00000038747Uncharacterized protein. (1063 aa)
LDLRLow density lipoprotein receptor. (859 aa)
KARS1Lysine--tRNA ligase. (629 aa)
CEBPABZIP domain-containing protein. (141 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (113 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
FCGR1AUncharacterized protein. (374 aa)
TAFA3Uncharacterized protein. (147 aa)
ENSGGOP00000032091Caspase 4; Belongs to the peptidase C14A family. (377 aa)
CD28CD28 molecule. (220 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
ENSGGOP00000030029ATP binding cassette subfamily C member 1. (1479 aa)
ENSGGOP00000029826Uncharacterized protein. (123 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
ENSGGOP00000029367Pyrin domain-containing protein. (110 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
C2CD4BC2 calcium dependent domain containing 4B. (355 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (300 aa)
ENSGGOP00000027573annotation not available (93 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
TTBK1Tau tubulin kinase 1. (1322 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
C2CD4CC2 calcium dependent domain containing 4C. (421 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
GPSM3G protein signaling modulator 3. (157 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LGALS2Galectin. (132 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
DHX9DExH-box helicase 9. (1270 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (441 aa)
BTKTyrosine-protein kinase. (693 aa)
C3Complement C3. (1663 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (393 aa)
TLR10Toll-like receptor. (811 aa)
MDKMidkine. (143 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
G3S121_GORGOUncharacterized protein. (261 aa)
G3S0Q7_GORGOSET domain containing 4. (440 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
NFKBIZNFKB inhibitor zeta. (718 aa)
C2CD4DC2 calcium dependent domain containing 4D. (353 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
PLA2G3Phospholipase A2 group III. (539 aa)
CCL3C-C motif chemokine. (92 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
G3RT49_GORGOcAMP responsive element binding protein 3 like 3. (461 aa)
G3RT38_GORGOADAM metallopeptidase domain 8. (824 aa)
IL6Interleukin 6. (234 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CCL1C-C motif chemokine. (96 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
NINJ1Ninjurin 1. (152 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
GRNGranulin precursor. (593 aa)
G3RID2_GORGOTIR domain-containing protein. (1033 aa)
G3RI71_GORGONACHT domain-containing protein. (1127 aa)
RPS19Ribosomal protein S19. (145 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
PDE2APhosphodiesterase. (941 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
NMIN-myc and STAT interactor. (307 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
G3RAJ9_GORGOCyclin dependent kinase 19. (446 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
TRADDDeath domain-containing protein. (251 aa)
NLRP1NLR family pyrin domain containing 1. (1471 aa)
LGALS1Galectin. (135 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NLRP10NLR family pyrin domain containing 10. (661 aa)
NLRP12NLR family pyrin domain containing 12. (1065 aa)
IFI35Interferon induced protein 35. (286 aa)
MMP8Matrix metallopeptidase 8. (467 aa)
DDTLUncharacterized protein. (164 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
CCL24SCY domain-containing protein. (64 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1331 aa)
G3QRS4_GORGOZP domain-containing protein. (290 aa)
CLOCKClock circadian regulator. (847 aa)
TNFSF18TNF superfamily member 18. (199 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
G3QT71_GORGOLymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AIM2Absent in melanoma 2. (343 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
G3QUX8_GORGOCalcium/calmodulin dependent protein kinase II inhibitor 1. (78 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
HYAL2Hyaluronidase. (473 aa)
OSMOncostatin M. (252 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
CD81Tetraspanin. (260 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
CD47CD47 molecule. (323 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PLA2G2APhospholipase A(2). (144 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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