STRINGSTRING
IL33 IL33 G3R037_GORGO G3R037_GORGO DDTL DDTL MMP8 MMP8 IFI35 IFI35 NLRP12 NLRP12 NLRP10 NLRP10 NFKBIA NFKBIA ZBP1 ZBP1 TNFSF11 TNFSF11 LGALS1 LGALS1 NLRP1 NLRP1 TRADD TRADD G3R8T5_GORGO G3R8T5_GORGO RIPK1 RIPK1 G3RAJ9_GORGO G3RAJ9_GORGO G3RAL4_GORGO G3RAL4_GORGO NMI NMI ALOX5AP ALOX5AP PDE2A PDE2A PLA2G2A PLA2G2A IL21 IL21 CD47 CD47 PTGER4 PTGER4 CD81 CD81 G3QX51_GORGO G3QX51_GORGO WNT5A WNT5A FABP4 FABP4 SERPINE1 SERPINE1 OSM OSM HYAL2 HYAL2 S100A12 S100A12 G3QUX8_GORGO G3QUX8_GORGO IL1B IL1B CCDC142 CCDC142 AIM2 AIM2 IFNG IFNG G3QT76_GORGO G3QT76_GORGO G3QT71_GORGO G3QT71_GORGO FFAR2 FFAR2 TNFSF18 TNFSF18 CLOCK CLOCK G3QRS4_GORGO G3QRS4_GORGO IL16 IL16 MGST2 MGST2 CCL24 CCL24 TRPV4 TRPV4 NPY5R NPY5R IL12B IL12B SUCNR1 SUCNR1 LGALS2 LGALS2 TLR2 TLR2 ETS1 ETS1 NLRC4 NLRC4 GPSM3 GPSM3 CTSC CTSC IL23A IL23A ADORA2B ADORA2B ITGA2 ITGA2 C2CD4C C2CD4C S100A9 S100A9 CX3CL1 CX3CL1 TTBK1 TTBK1 STAP1 STAP1 NKG7 NKG7 TREM2 TREM2 RPS19 RPS19 G3RI71_GORGO G3RI71_GORGO G3RID2_GORGO G3RID2_GORGO GRN GRN IL18 IL18 CCR7 CCR7 IL1RL1 IL1RL1 PYCARD PYCARD NINJ1 NINJ1 CCR2 CCR2 PTGS2 PTGS2 CCL1 CCL1 TNFSF4 TNFSF4 IL6 IL6 G3RT38_GORGO G3RT38_GORGO G3RT49_GORGO G3RT49_GORGO G3RVS4_GORGO G3RVS4_GORGO S100A8 S100A8 CCL3 CCL3 PLA2G3 PLA2G3 TLR7 TLR7 C2CD4D C2CD4D NFKBIZ NFKBIZ PDCD4 PDCD4 NAIP NAIP GPRC5B GPRC5B TNIP1 TNIP1 CEBPB CEBPB ENSGGOP00000045267 ENSGGOP00000045267 NLRP6 NLRP6 ENSGGOP00000046335 ENSGGOP00000046335 TNFRSF11A TNFRSF11A ENSGGOP00000046758 ENSGGOP00000046758 NUPR1 NUPR1 ENSGGOP00000049861 ENSGGOP00000049861 APP APP PTGER3 PTGER3 IL17RA IL17RA G3S0Q7_GORGO G3S0Q7_GORGO G3S121_GORGO G3S121_GORGO IL2 IL2 MDK MDK TLR10 TLR10 NAPEPLD NAPEPLD PIK3CG PIK3CG C3 C3 BTK BTK PLA2G7 PLA2G7 DHX9 DHX9 TNFRSF1A TNFRSF1A TLR3 TLR3 SNCA SNCA ENSGGOP00000027573 ENSGGOP00000027573 LILRA5 LILRA5 PLCG2 PLCG2 C2CD4B C2CD4B IDO1 IDO1 ENSGGOP00000029367 ENSGGOP00000029367 ENSGGOP00000029762 ENSGGOP00000029762 ENSGGOP00000029826 ENSGGOP00000029826 ENSGGOP00000030029 ENSGGOP00000030029 ENSGGOP00000030478 ENSGGOP00000030478 CD28 CD28 ENSGGOP00000032091 ENSGGOP00000032091 TAFA3 TAFA3 FCGR1A FCGR1A TSLP TSLP LRRK2 LRRK2 VAMP8 VAMP8 CEBPA CEBPA KARS1 KARS1 LDLR LDLR ENSGGOP00000038747 ENSGGOP00000038747 SNX4 SNX4 GPR4 GPR4 CCN4 CCN4 IL15 IL15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL33Interleukin 33. (270 aa)
G3R037_GORGOFem-1 homolog A. (653 aa)
DDTLUncharacterized protein. (164 aa)
MMP8Matrix metallopeptidase 8. (467 aa)
IFI35Interferon induced protein 35. (286 aa)
NLRP12NLR family pyrin domain containing 12. (1065 aa)
NLRP10NLR family pyrin domain containing 10. (661 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
LGALS1Galectin. (135 aa)
NLRP1NLR family pyrin domain containing 1. (1471 aa)
TRADDDeath domain-containing protein. (251 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
G3RAJ9_GORGOCyclin dependent kinase 19. (446 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
NMIN-myc and STAT interactor. (307 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
PDE2APhosphodiesterase. (941 aa)
PLA2G2APhospholipase A(2). (144 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CD47CD47 molecule. (323 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
CD81Tetraspanin. (260 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
OSMOncostatin M. (252 aa)
HYAL2Hyaluronidase. (473 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
G3QUX8_GORGOCalcium/calmodulin dependent protein kinase II inhibitor 1. (78 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
AIM2Absent in melanoma 2. (343 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G3QT71_GORGOLymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
TNFSF18TNF superfamily member 18. (199 aa)
CLOCKClock circadian regulator. (847 aa)
G3QRS4_GORGOZP domain-containing protein. (290 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1331 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
CCL24SCY domain-containing protein. (64 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
LGALS2Galectin. (132 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
GPSM3G protein signaling modulator 3. (157 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
C2CD4CC2 calcium dependent domain containing 4C. (421 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
TTBK1Tau tubulin kinase 1. (1322 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
RPS19Ribosomal protein S19. (145 aa)
G3RI71_GORGONACHT domain-containing protein. (1127 aa)
G3RID2_GORGOTIR domain-containing protein. (1033 aa)
GRNGranulin precursor. (593 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NINJ1Ninjurin 1. (152 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CCL1C-C motif chemokine. (96 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
IL6Interleukin 6. (234 aa)
G3RT38_GORGOADAM metallopeptidase domain 8. (824 aa)
G3RT49_GORGOcAMP responsive element binding protein 3 like 3. (461 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
CCL3C-C motif chemokine. (92 aa)
PLA2G3Phospholipase A2 group III. (539 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
C2CD4DC2 calcium dependent domain containing 4D. (353 aa)
NFKBIZNFKB inhibitor zeta. (718 aa)
PDCD4Programmed cell death 4. (469 aa)
NAIPUncharacterized protein. (198 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
TNIP1TNFAIP3 interacting protein 1. (645 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
NLRP6Uncharacterized protein. (912 aa)
ENSGGOP00000046335Uncharacterized protein. (118 aa)
TNFRSF11ATNF receptor superfamily member 11a. (616 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
ENSGGOP00000049861Uncharacterized protein; Belongs to the synaptobrevin family. (230 aa)
APPAmyloid beta precursor protein. (771 aa)
PTGER3Prostaglandin E receptor 3. (418 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
G3S0Q7_GORGOSET domain containing 4. (440 aa)
G3S121_GORGOUncharacterized protein. (261 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
MDKMidkine. (143 aa)
TLR10Toll-like receptor. (811 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (393 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
C3Complement C3. (1663 aa)
BTKTyrosine-protein kinase. (693 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (441 aa)
DHX9DExH-box helicase 9. (1270 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
ENSGGOP00000027573annotation not available (93 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (300 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
C2CD4BC2 calcium dependent domain containing 4B. (355 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
ENSGGOP00000029367Pyrin domain-containing protein. (110 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
ENSGGOP00000029826Uncharacterized protein. (123 aa)
ENSGGOP00000030029ATP binding cassette subfamily C member 1. (1479 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
CD28CD28 molecule. (220 aa)
ENSGGOP00000032091Caspase 4; Belongs to the peptidase C14A family. (377 aa)
TAFA3Uncharacterized protein. (147 aa)
FCGR1AUncharacterized protein. (374 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (113 aa)
CEBPABZIP domain-containing protein. (141 aa)
KARS1Lysine--tRNA ligase. (629 aa)
LDLRLow density lipoprotein receptor. (859 aa)
ENSGGOP00000038747Uncharacterized protein. (1063 aa)
SNX4Sorting nexin 4. (450 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CCN4Cellular communication network factor 4. (368 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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